A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted
A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
대표청구항▼
1. An implantable medical device comprising: a substrate;at least one reservoir disposed in the substrate, wherein the at least one reservoir has an opening and contains a sensor;at least one reservoir cap closing off the opening of the at least one reservoir to isolate the sensor from an environmen
1. An implantable medical device comprising: a substrate;at least one reservoir disposed in the substrate, wherein the at least one reservoir has an opening and contains a sensor;at least one reservoir cap closing off the opening of the at least one reservoir to isolate the sensor from an environmental component outside the at least one reservoir, the at least one reservoir cap being impermeable to the environmental component; anda power source and electrical circuitry operable to induce a phase chance in the at least one reservoir cap to disintegrate the at least one reservoir cap and thereby expose the sensor to the environmental component. 2. The device of claim 1, wherein the sensor provides an output signal for transmission to a remote receiver source. 3. The device of claim 2, wherein the transmission comprises radio transmission. 4. The device of claim 2, wherein the output signal is used in controlling and monitoring the release of molecules from another reservoir in the device or from another device. 5. The device of claim 1, wherein the sensor comprises a sensor for measuring electrical conductivity. 6. The device of claim 1, wherein the sensor include an electrochemical transducer. 7. The device of claim 6, wherein the transducer is amperometric. 8. The device of claim 6, wherein the transducer is potentiometric. 9. The device of claim 1, wherein the sensor comprises an enzyme or antibody recognition element. 10. The device of claim 1, wherein the sensor comprises a sensor for detecting carbon dioxide, carbon monoxide, ammonia, dioxygen, ethanol, ionized calcium, sodium ion, potassium ion, lithium ion, hydrogen ion, chloride ion, magnesium ion, ammonium ion, hydrogen peroxide, ascorbic acid, cholesterol, uric acid, esterified cholesterol urea, creatinine, creatine, triglycerides, lactate dehydrogenase, creatine kinase, alkaline phosphatase, creatine kinase-MB, alanine transaminase, aspartate transaminase, bilirubin, amylase, or lipase. 11. The device of claim 1, wherein the reservoir cap comprises a metal film. 12. The device of claim 1, wherein the device is configured for surgical implantation or injection into the body of a patient. 13. The device of claim 1, having a plurality of reservoirs, a plurality of sensors disposed in the plurality of reservoirs, and a plurality of discrete reservoir caps.
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