IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0169914
(2008-07-09)
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| 등록번호 |
US-8442632
(2013-05-14)
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발명자
/ 주소 |
- Kullok, Saul
- Kullok, Yossi
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| 출원인 / 주소 |
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| 대리인 / 주소 |
Sterne, Kessler, Goldstein & Fox PLLC
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| 인용정보 |
피인용 횟수 :
8 인용 특허 :
87 |
초록
▼
A method and apparatus for affecting the autonomic nervous system of a subject using stimuli based on separate analysis of the sympathetic and/or parasympathetic branches of the subject's autonomic nervous system. The present invention also relates to a method and apparatus for affecting the autonom
A method and apparatus for affecting the autonomic nervous system of a subject using stimuli based on separate analysis of the sympathetic and/or parasympathetic branches of the subject's autonomic nervous system. The present invention also relates to a method and apparatus for affecting the autonomic nervous system, wherein stimuli is applied in coordination with cyclical activities of the subjects body such as respiration or cardiac cycle.
대표청구항
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1. A method comprising: applying at least one stimulus to a subject, wherein the at least one stimulus is modulated by at least one variable stimulus parameter;monitoring at least one subject parameter of the subject;separately analyzing at least one of sympathetic and parasympathetic activity of th
1. A method comprising: applying at least one stimulus to a subject, wherein the at least one stimulus is modulated by at least one variable stimulus parameter;monitoring at least one subject parameter of the subject;separately analyzing at least one of sympathetic and parasympathetic activity of the subject based on the monitored subject parameter; andcontrolling the application of the at least one stimulus by modulating the at least one variable stimulus parameter in accordance with separate analysis from the sympathetic activity or the parasympathetic activity of the subject. 2. The method of claim 1, wherein the at least one stimulus affects afferent neural pathways of the subject. 3. The method of claim 1, wherein application of the at least one stimulus and monitoring of the at least one subject parameter are performed non-invasively. 4. The method of claim 1, wherein the at least one variable stimulus parameter is selected to affect at least one type of sensorial receptors of the subject. 5. The method of claim 4, further comprising: applying a second stimulus to the subject, wherein the second stimulus is modulated by at least a second variable stimulus parameter. 6. The method of claim 5, wherein the at least one variable stimulus parameter and the second variable stimulus parameter each comprise at least one of amplitude and frequency. 7. The method of claim 6, wherein the at least one stimulus comprises light and the second stimulus comprises sound. 8. The method of claim 1, wherein the at least one subject parameter comprises at least one of a physiological, cognitive, and behavioral activity of the subject. 9. The method of claim 1, wherein the monitoring is accomplished prior to application of stimuli. 10. The method of claim 9, further comprising: discontinuing monitoring during application of the at least one stimulus. 11. The method according to claim 1, wherein said monitoring occurs during application of the stimuli. 12. The method according to claim 11, wherein said controlling comprises continuously adjusting said stimuli application in response to the monitored subject parameter. 13. The method of claim 1, wherein the at least one subject parameter comprises cardiovascular activity. 14. The method of claim 13, wherein the at least one subject parameter comprises electrical currents related to heart contraction. 15. The method of claim 14, wherein the at least one subject parameter is monitored by an electrocardiograph. 16. The method of claim 1, wherein the at least one subject parameter comprises an electrophysiological parameter, the controlling comprising: converting the electrophysiological parameter to a heart rate variability measurement comprising a separate frequency domain analysis of sympathetic activity changes and of parasympathetic activity changes; andmodulating the at least one variable stimulus parameter in response to changes in the heart rate variability measurement, wherein changes are selected from a group comprising the analyzed sympathetic activity changes, the analyzed parasympathetic activity changes, and a predefined mathematical relationship between the sympathetic and parasympathetic activity. 17. A method for affecting the autonomic nervous system of a subject comprising: measuring the heart rate variability of the subject;separately analyzing at least one of sympathetic and parasympathetic activity of the subject based on the heart rate variability measurement; andapplying at least one stimulus to the subject in response to at least one of the sympathetic and parasympathetic activity of the subject. 18. An apparatus for affecting the autonomic nervous system of a subject comprising: means for obtaining a plurality of power spectra, wherein each power spectrum depicts heart rate variability of the subject as a function of frequency, and the power spectra are obtained over predetermined time windows;means for measuring area under each power spectrum in at least one predetermined frequency range, and the maximum value of variability in the predetermined frequency range; andmodulating means for modulating a first parameter of a stimulus to be applied to the subject based on a change in the area between two power spectra and for modulating a second parameter of the stimulus based on a change in the maximum value of variability between the two power spectra. 19. The method of claim 1, wherein modulating the at least one variable stimulus parameter comprises altering the variable stimulus parameter away from a default value in a direction and amplitude defined by a preselected function. 20. The method of claim 1, wherein modulating the at least one variable stimulus parameter comprises modulating the at least one variable stimulus parameter in coordination with a preselected biological cycle of the subject. 21. A computer-readable storage device having instructions stored thereon, execution of which, by a computing device, causes the computing device to perform operations comprising: applying at least one stimulus to a subject, wherein the at least one stimulus is modulated by at least one variable stimulus parameter;monitoring at least one subject parameter of the subject;separately analyzing at least one of sympathetic and parasympathetic activity of the subject based on the subject parameter; andcontrolling the application of the at least one stimulus by modulating the at least one variable stimulus parameter in accordance with separate analysis from the sympathetic activity or the parasympathetic activity of the subject. 22. The computer-readable storage device of claim 21, wherein the at least one stimulus affects afferent neural pathways of the subject. 23. The computer-readable storage device of claim 21, wherein application of the at least one stimulus and monitoring of the at least one subject parameter are performed non-invasively. 24. The computer-readable storage device of claim 21, wherein the at least one variable stimulus parameter is selected to affect at least one type of sensorial receptors of the subject. 25. The computer-readable storage device of claim 24, the operations further comprising: applying a second stimulus to the subject, wherein the second stimulus is modulated by at least a second variable stimulus parameter. 26. The computer-readable storage device of claim 25, wherein the at least one variable stimulus parameter and the second variable stimulus parameter each comprise at least one of amplitude and frequency. 27. The computer-readable storage device of claim 26, wherein the at least one stimulus comprises light and the second stimulus comprises sound. 28. The computer-readable storage device of claim 21, wherein the at least one subject parameter comprises at least one of a physiological, cognitive, and behavioral activity of the subject. 29. The computer-readable storage device of claim 21, wherein the monitoring is accomplished prior to application of stimuli. 30. The computer-readable storage device of claim 29, the operations further comprising: discontinuing monitoring during application of the at least one stimulus. 31. The computer-readable storage device of claim 21, wherein the at least one subject parameter comprises cardiovascular activity. 32. The computer-readable storage device of claim 31, wherein the at least one subject parameter comprises electrical currents related to heart contraction. 33. The computer-readable storage device of claim 32, wherein the at least one subject parameter is monitored by an electrocardiograph. 34. The computer-readable storage device of claim 21, wherein the at least one subject parameter comprises an electrophysiological parameter, the controlling comprising: converting the electrophysiological parameter to a heart rate variability measurement comprising a separate frequency domain analysis of sympathetic activity changes and of parasympathetic activity changes; andmodulating the at least one variable stimulus parameter in response to changes in the heart rate variability measurement, wherein changes are selected from a group comprising the analyzed sympathetic activity changes, the analyzed parasympathetic activity changes, and a predefined mathematical relationship between the sympathetic and parasympathetic activity. 35. The computer-readable storage device of claim 21, wherein modulating the at least one variable stimulus parameter comprises altering the variable stimulus parameter away from a default value in a direction and amplitude defined by a preselected function. 36. The computer-readable storage device of claim 21, wherein modulating the at least one variable stimulus parameter comprises modulating the at least one variable stimulus parameter in coordination with a preselected biological cycle of the subject. 37. An apparatus comprising: a patient monitor device configured to monitor at least one subject parameter of a subject and to separately analyze at least one of sympathetic and parasympathetic activity of the subject based on the subject parameter; anda stimuli modulating unit configured to: apply at least one stimulus to the subject, wherein the at least one stimulus is modulated by at least one variable stimulus parameter, andcontrol the application of the at least one stimulus by modulating the at least one variable stimulus parameter in accordance with separate analysis from the sympathetic activity or the parasympathetic activity of the subject. 38. The apparatus of claim 37, wherein the at least one stimulus affects afferent neural pathways of the subject. 39. The apparatus of claim 37, wherein application of the at least one stimulus and monitoring of the at least one subject parameter are performed non-invasively. 40. The apparatus of claim 37, wherein the at least one variable stimulus parameter is selected to affect at least one type of sensorial receptors of the subject. 41. The apparatus of claim 40, wherein the stimuli modulating unit is further configured to apply a second stimulus to the subject, wherein the second stimulus is modulated by at least a second variable stimulus parameter. 42. The apparatus of claim 41, wherein the at least one variable stimulus parameter and the second variable stimulus parameter each comprise at least one of amplitude and frequency. 43. The apparatus of claim 42, wherein the at least one stimulus comprises light and the second stimulus comprises sound. 44. The apparatus of claim 37, wherein the at least one subject parameter comprises at least one of a physiological, cognitive, and behavioral activity of the subject. 45. The apparatus of claim 37, wherein the monitoring is accomplished prior to application of stimuli. 46. The apparatus of claim 45, wherein the stimuli modulating unit is further configured to discontinue monitoring during application of the at least one stimulus. 47. The apparatus of claim 37, wherein the at least one subject parameter comprises cardiovascular activity. 48. The apparatus of claim 37, wherein the at least one subject parameter comprises electrical currents related to heart contraction. 49. The apparatus of claim 38, wherein the at least one subject parameter is monitored by an electrocardiograph. 50. The apparatus of claim 37, wherein the at least one subject parameter comprises an electrophysiological parameter, wherein the patient monitor device is further configured to convert the electrophysiological parameter to a heart rate variability measurement comprising a separate frequency domain analysis of sympathetic activity changes and of parasympathetic activity changes, andwherein the stimuli modulating unit is further configured to modulate the at least one variable stimulus parameter in response to changes in the heart rate variability measurement, wherein changes are selected from a group comprising the analyzed sympathetic activity changes, the analyzed parasympathetic activity changes, and a predefined mathematical relationship between the sympathetic and parasympathetic activity. 51. The apparatus of claim 37, wherein modulating the at least one variable stimulus parameter comprises altering the variable stimulus parameter away from a default value in a direction and amplitude defined by a preselected function. 52. The apparatus of claim 37, wherein modulating the at least one variable stimulus parameter comprises modulating the at least one variable stimulus parameter in coordination with a preselected biological cycle of the subject. 53. The method according to claim 1, wherein said controlling comprises continuously adjusting said stimuli application in response to the monitored subject parameter.
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