초록 ▼

A method of determining the respiratory function of a subject is disclosed, the method comprising measuring the concentration of water vapor in the gas stream exhaled by the subject, and from the measured water vapor concentration determining the respiratory function of the subject. Mathematical tec

A method of determining the respiratory function of a subject is disclosed, the method comprising measuring the concentration of water vapor in the gas stream exhaled by the subject, and from the measured water vapor concentration determining the respiratory function of the subject. Mathematical techniques for analyzing the data obtained from the measurement of concentrations of gaseous components in an exhaled gas stream are also disclosed and their use in determining the lung function of a subject.

대표청구항 ▼

1. A method of determining the respiratory function of a subject, the method comprising: measuring the concentration of water vapour in the gas stream exhaled by the subject using an electrochemical sensor, wherein said measuring comprises causing the gas stream to impinge on a sensing element of sa

1. A method of determining the respiratory function of a subject, the method comprising: measuring the concentration of water vapour in the gas stream exhaled by the subject using an electrochemical sensor, wherein said measuring comprises causing the gas stream to impinge on a sensing element of said sensor, the sensing element comprising a working electrode, a counter electrode and a layer of ion exchange material extending between the working electrode and the counter electrode, the ion-exchange layer being configured to form an electrical contact between the working electrode and the counter electrode when exposed to water vapour in said gas stream, and applying a pulsed electric potential across the working electrode and counter electrode whereby the sensor generates an output representative of the change of concentration of water vapour over time in said gas stream;employing a processor to use the output of the sensor to generate data providing a profile representative of said change of water vapour concentration over time in the exhaled gas stream; andfrom said profile directly determining the respiratory function of the subject. 2. The method according to claim 1, wherein the concentration of water vapour is measured for the duration of at least one complete exhalation. 3. The method according to claim 2, wherein the concentration of water vapour is measured during tidal breathing by the subject. 4. The method according to claim 1, wherein the exhaled gas stream is exhaled from the mouth of the subject. 5. The method of claim 1, wherein said pulsed potential alternates between a rest potential and a potential above the reaction threshold potential. 6. The method of claim 1, wherein the voltage is pulsed at a frequency of from 1 to 500 Hz. 7. The method of claim 1, wherein the slope of the ascending phase of the profile is measured and said slope is used to determine the respiratory function of the subject. 8. The method according to claim 7, further comprising measuring the slope of the plateau phase of the profile. 9. The method according to claim 8, wherein the ratio of the slope of the ascending phase and the plateau phase is determined. 10. The method according to claim 1 which further comprises analyzing the portion of the profile in the region of the transition from the ascending phase to the plateau phase and using the results of the analysis to make the determination of the respiratory function of the subject. 11. The method of claim 1 wherein said processor generates a display of said profile. 12. The method according to claim 1 wherein storage means are provided for storing a plurality of pre-existing profiles representative of change of concentration of water vapour over time in an exhaled gas stream and means are provided for comparing the profile thus obtained with one or more pre-existing profiles retrieved from the storage means. 13. The method according to claim 12 wherein said profile is compared with one or more pre-existing such profiles obtained from the subject. 14. The method of claim 12 wherein the means for comparing the profiles comprises display means for displaying a plurality of profiles for visual comparison. 15. The method of claim 1 wherein the ion-exchange material comprises a sulphonated tetrafluoroethylene copolymer. 16. The method of claim 1 wherein said subject is suffering from asthma or chronic obstructive pulmonary (COPD).