Methods for treating a wound using epidermal growth factor formulation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/18
C07K-014/485
출원번호
US-0915727
(2006-05-18)
등록번호
US-8481049
(2013-07-09)
우선권정보
IN-642/CHE/2005 (2005-05-27)
국제출원번호
PCT/IN2006/000168
(2006-05-18)
§371/§102 date
20080616
(20080616)
국제공개번호
WO2006/126212
(2006-11-30)
발명자
/ 주소
Ella, Krishna Murthy
Vellimedu, Srinivas Kannappa
출원인 / 주소
Bharat Biotech International Limited
대리인 / 주소
Fenwick & West
인용정보
피인용 횟수 :
2인용 특허 :
5
초록▼
A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, car
A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, carrier/diluent, and optionally pH regulating agent and humectant.
대표청구항▼
1. A method for treating a wound, the method comprising steps of administering an effective amount of a stabilized formulation consisting essentially of a therapeutically effective amount of recombinant human epidermal growth factor present in a range of about 0.001% to about 0.9% (w/w); L lysine hy
1. A method for treating a wound, the method comprising steps of administering an effective amount of a stabilized formulation consisting essentially of a therapeutically effective amount of recombinant human epidermal growth factor present in a range of about 0.001% to about 0.9% (w/w); L lysine hydrochloric acid present in the range of about 0.2% to about 0.5% (w/w) and mannitol present in the range of about 1% to about 10% (w/w) as stabilizers; sodium methyl paraben present in the range of about 0.016% to about 0.18% (w/w) and sodium propyl paraben present in the range of about 0.01% to about 0.02% (w/w) as preservatives; poly acrylic acid present in the range of about 0.25% to about 1% (w/w) as a thickening agent; water present in the range of about 50% to about 99.5% (w/v) as a carrier; triethanol amine present in an effective amount to maintain the pH of the composition between 6.3 to 6.4 as a pH regulating agent; glycerol present in the range of about 1% to about 2.5% (w/w) as a humectant; and a therapeutic agent present in a range of about 0.005% to about 0.5% (w/w). 2. The method of claim 1, wherein the wound is diabetic foot ulcer, corneal ulcer, gastric ulcer, venous ulcer, arterial ulcer pressure ulcer, mouth ulcer, skin burns caused by irradiation used in cancer therapy, thermal injury, laceration, surgical wound, bedsores, or gastro duodenal ulcer. 3. The method of claim 1, wherein the stabilized formulation is a topical formulation in the form of gel, spray, ointment, cream and lotion, an oral formulation in the form of tablet and capsule, and in a parenteral formulation in the form of injections. 4. The method as claimed in claim 1, wherein the therapeutic agent is an antiinfective agent silver sulphadiazine present in a range of about 0.005% to about 0.5% (w/w). 5. The method as claimed in claim 1, wherein the therapeutic agent is a recombinant antibiotic lysostaphin present in the range of about 0.01% to about 0.1% (w/w). 6. The method as claimed in claim 1, wherein the therapeutic agent is hyaluronic acid present in the range of about 0.05% to about 5% (w/w). 7. The method as claimed in claim 1, wherein the therapeutic agent is Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) present in the range of about 0.001% to 0.005% (w/w). 8. The method as claimed in claim 1, wherein the therapeutic agent is Platelet Derived Growth Factor present in the range of about 0.005% to about 0.01% (w/w). 9. The method as claimed in claim 1, wherein the therapeutic agent is an immune modulator beta 1,3-D-glucan present in the range of about 0.5% to about 2% (w/w). 10. The method as claimed in claim 1, wherein the therapeutic agent is present in a combination with a vaso constrictor hydrocortisone acetate present in the range of about 0.215% (w/w), zinc oxide present in the range of about 0.015% to about 5% (w/w), lindocaine present in the range of about 2% to 3% (w/w), and allantoin present in the range of about 0.4% to about 1.5% (w/w). 11. The method as claimed in claim 1, wherein the therapeutic agent is present in a combination of natural product(s) consisting of aloevera; turmeric; sandalwood; and honey. 12. The method as claimed in claim 1, wherein the therapeutic agent is present in a combination of natural product(s) consisting of aloevera; Vitamin E and Vitamin C. 13. The method as claimed in claim 1, wherein the therapeutic agent is protein free blood extract, present in the range of about 0.015% to 0.02% (w/w). 14. The method as claimed in claim 1, wherein the therapeutic agent is present in combination of zinc oxide present in the range of about 0.015% to about 5% (w/w), salicylic acid present in the range of about 1% to about 5% (w/w) and clobetasol propionate present in the range of about 0.1% to about 1% (w/w).
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이 특허에 인용된 특허 (5)
Edwards Linda M. (Saffron Walden GBX), Antibacterial and/or antifungal compositions for topical application.
Finkenaur Amy L. (Somerville NJ) Cohen Jonathan M. (Marlboro NJ) Shalaby Shalaby W. (Lebanon NJ) Sandoval Elisabeth A. (Irvine CA) Bezwada Rao S. (Whitehouse Station NJ) Kronenthal Richard L. (Fairla, Gel formulations containing growth factors and acrylamide polymer.
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