최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0916289 (2010-10-29) |
등록번호 | US-8483793 (2013-07-09) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 12 인용 특허 : 408 |
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
1. A method for providing a substantially noise-free glucose signal for a glucose sensor implanted in a host, the method comprising: providing a sensor, the sensor comprising a first working electrode disposed beneath an active enzymatic portion of a membrane system, and a second working electrode d
1. A method for providing a substantially noise-free glucose signal for a glucose sensor implanted in a host, the method comprising: providing a sensor, the sensor comprising a first working electrode disposed beneath an active enzymatic portion of a membrane system, and a second working electrode disposed beneath an inactive-enzymatic or a non-enzymatic portion of the membrane system, wherein the membrane system is configured to substantially reduce one or more interfering species from reaching the first working electrode and the second working electrode;generating a first signal associated with the first working electrode;generating a second signal associated with the second working electrode;processing the first signal and the second signal to produce a glucose signal that is substantially without signal contribution from interfering species; andperforming, using electronic circuitrty, a self-diagnosis by measuring an auxiliary signal to determine a change in sensitivity of the sensor using one or more electrodes of the sensor, independent of a blood glucose reference value. 2. The method of claim 1, wherein determining a change in sensitivity comprises measuring a non-glucose analyte concentration. 3. The method of claim 1, further comprising requesting an external reference value in response to the determined sensitivity change. 4. The method of claim 1, further comprising calibrating the glucose signal at a frequency responsive to the determined sensitivity change. 5. The method of claim 1, further comprising calibrating the glucose signal based on the determined change in sensitivity. 6. The method of claim 1, further comprising determining a sensor stability based on the self-diagnosis. 7. The method of claim 6, further comprising controlling a display of the glucose signal based on the determined sensor stability. 8. The method of claim 1, further comprising implanting the sensor in a host. 9. A continuous glucose monitoring system configured for measuring glucose concentration in a host, the system comprising: a sensor comprising a first working electrode disposed beneath an active enzymatic portion of a membrane system and configured to generate a first signal, and a second working electrode disposed beneath an inactive-enzymatic or a non-enzymatic portion of the membrane system and configured to generate a second signal, wherein the membrane system is configured to substantially reduce interfering species from reaching the first working electrode and second working electrode; andelectronics configured to process the first signal and the second signal to produce a glucose signal that is substantially without signal contribution from interfering species, wherein the electronics are configured to perform a self-diagnosis based on a measurement from an auxiliary signal indicative of a change in sensitivity of the sensor, and wherein the measurement is obtained from one or more electrodes of the sensor independent of a blood glucose reference value. 10. The system of claim 9, wherein the measurement is based on a non-glucose analyte concentration. 11. The system of claim 9, wherein the electronics are configured to request an external reference value in response to the measurement exceeding a threshold value. 12. The system of claim 9, wherein the electronics are configured to calibrate the glucose signal at a frequency responsive to the measurement. 13. The system of claim 9, wherein the electronics are configured to calibrate the glucose signal based on the measurement. 14. The system of claim 9, wherein the electronics are configured to determine a sensor stability based on the self-diagnosis. 15. The system of claim 14, wherein the electronics are configured to control a display of the glucose signal based on the determined sensor stability. 16. The system of claim 9, wherein the membrane system comprises an interference domain configured to substantially block at least one interferent selected from the group consisting of hydrogen peroxide, reactive oxygen species, and reactive nitrogen species. 17. The system of claim 9, wherein the membrane system comprises an interference domain configured to substantially block at least one non-constant noise causing interferent. 18. The system of claim 9, wherein the membrane system comprises an interference domain comprising an auxiliary electrode comprising a conductive material, wherein the auxiliary electrode is configured to modify an electrochemical interferant such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the first working electrode or the second working electrode. 19. The system of claim 18, wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh, a grid, and a plurality of spaced wires. 20. The system of claim 18, wherein the auxiliary electrode comprises a polymer, wherein the polymer comprises a material that is permeable to an electrochemical interferant. 21. The system of claim 9, wherein the membrane system comprises an interference domain comprising a blend of at least one hydrophilic component and at least one hydrophobic component, wherein the interference domain is configured such that the sensor provides an equivalent analyte signal response to at least one interferent that does not substantially affect accuracy of an in vivo analyte concentration measurement, and wherein the sensor is configured to provide a linear response to analyte concentration, in vivo, within a physiological range. 22. The system of claim 21, wherein an amount of the hydrophobic component is greater than an amount of the hydrophilic component. 23. The system of claim 21, wherein the blend of at least one hydrophilic component and at least one hydrophobic component comprises at least one hydrophilic substituent of a polymer and at least one hydrophobic substituent of a polymer. 24. The system of claim 21, wherein the hydrophilic component and the hydrophobic component each comprise at least one cellulosic derivative. 25. The system of claim 24, wherein the cellulosic derivative comprises at least one of cellulose acetate or cellulose acetate butyrate. 26. The system of claim 9, wherein the membrane system comprises an interference domain comprising a silicone material configured to allow transport of an analyte therethrough. 27. The system of claim 26, wherein the silicone material comprises a blend of a silicone elastomer and a hydrophilic copolymer. 28. The system of claim 27, wherein the hydrophilic copolymer comprises hydroxy substituents. 29. The system of claim 27, wherein the hydrophilic copolymer comprises a PLURONIC® polymer. 30. The system of claim 27, wherein the silicone material has a micellar jacket structure. 31. The system of claim 9, wherein the membrane system comprises an interference domain comprising a polyurethane. 32. The system of claim 9, wherein the membrane system comprises an interference domain comprising a polymer having pendant ionic groups. 33. The system of claim 9, wherein the membrane system comprises an interference domain comprising a polymer membrane having a predetermined pore size that restricts diffusion of high molecular weight species. 34. The system of claim 33, wherein the high molecular weight species comprise at least one of glucose and ascorbic acid. 35. The system of claim 9, wherein the sensor is configured to be subcutaneously implanted. 36. The system of claim 9, wherein the sensor is configured to be intravascularly implanted. 37. The system of claim 9, wherein the sensor comprises an architecture with at least one dimension less than about 1 mm. 38. The system of claim 9, wherein the membrane system comprises an interference domain configured to substantially block passage therethrough of at least one interferent such that an equivalent glucose signal response of the interferent is less than about 60 mg/dl. 39. The system of claim 38, wherein an equivalent glucose signal response of the interferent is less than about 30 mg/dL. 40. The system of claim 39, wherein the equivalent glucose signal response of the interferent is less than about 10 mg/dL. 41. The system of claim 9, wherein the membrane system comprises at least one compound selected from the group consisting of Nafion, sulfonated polyether sulfone, polyamino-phenol and polypyrrole. 42. The system of claim 9, wherein the membrane system comprises at least one enzyme configured to metabolize at least one interferent, wherein the enzyme is selected from the group consisting of a peroxidase and an oxidase. 43. The system of claim 9, wherein the membrane system comprises an interference domain comprising a sorbent having an affinity for an interfering species. 44. The system of claim 9, wherein the sensor comprises a mechanism configured to increase flow around at least a portion of the sensor. 45. The system of claim 44, wherein the mechanism comprises a physical spacer. 46. The system of claim 44, wherein the mechanism comprises at least one member of the group consisting of a hydrogel, a scavenging agent, a bioactive agent, a shedding layer, and an interferent scavenger. 47. The system of claim 44, wherein the mechanism comprises an auxiliary electrode configured to electrochemically modify electrochemical interferants to render them substantially non-electroactively reactive at the first working electrode and the second working electrode.
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