Polymer matrix, uses thereof and a method of manufacturing the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B32B-015/08
B32B-015/18
B32B-015/20
B32B-018/00
B32B-027/08
B32B-027/10
B32B-027/20
B32B-027/28
B32B-027/30
B32B-027/32
B32B-027/34
출원번호
US-0303554
(2007-06-05)
등록번호
US-8497017
(2013-07-30)
국제출원번호
PCT/SE2007/000543
(2007-06-05)
§371/§102 date
20090609
(20090609)
국제공개번호
WO2007/142579
(2007-12-13)
발명자
/ 주소
Ohrlander, Mattias
Södervall, Billy
출원인 / 주소
Bactiguard AB
대리인 / 주소
Morrison & Foerster LLP
인용정보
피인용 횟수 :
0인용 특허 :
20
초록▼
The present invention relates to a polymer matrix, characterized in that it comprises a) an electron donating constituent and b) metal particles comprising at least one metal chosen from palladium, gold, ruthenium, rhodium, osmium, iridium, and platinum. The polymer matrix makes it possible to impro
The present invention relates to a polymer matrix, characterized in that it comprises a) an electron donating constituent and b) metal particles comprising at least one metal chosen from palladium, gold, ruthenium, rhodium, osmium, iridium, and platinum. The polymer matrix makes it possible to improve the biocompatibility and antimicrobial properties of substrates coated with said polymer matrix.
대표청구항▼
1. A polymer matrix, characterized in that it comprises a) an electron donating constituent andb) metal particles comprising palladium and gold,wherein the metal particles have an average particle diameter of from about 10 to about 10000 Å and wherein said electron donating constituent are particles
1. A polymer matrix, characterized in that it comprises a) an electron donating constituent andb) metal particles comprising palladium and gold,wherein the metal particles have an average particle diameter of from about 10 to about 10000 Å and wherein said electron donating constituent are particles comprising silver. 2. The polymer matrix according to claim 1, wherein said particles comprising silver further comprise copper or zinc. 3. The polymer matrix according to claim 1, wherein said polymer matrix is a hydrogel. 4. The polymer matrix according to claim 1, wherein said polymer matrix comprises at least one component selected from the group consisting of: acrylamide,agarose,albumin,alginate-acrylate,alginate-(polyethylene oxide-polypropylene oxide-polyethylene oxide),carboxymethyl amylose,carboxymethyl cellulose,carboxymethyl chitin,carrageenan,chitosan,chondroitin sulfate,chondroitin-6-sulfate,collagen,collagen-acrylate,dermatin sulfate,dextran,dextran sulfate,fibrin,fibrinogen,gelatin,heparin,heparin sulfate,hyaluronic acid (HA),hyaluronic acid-g-N-isopropyl acrylamide (HA-g-NIPAAm),hydroxyethyl methacrylate (HEMA),hydroxypropyl methacrylamide-based copolymers,methylene-bis-acrylamide (MBAAm),pectin,phosphorylcholine,poly(2-hydroxyethyl methacrylate),polyacrylamide (PAAm),poly(acrylic acid) (PAAc),polyacrylonitrile (PAN),poly(acrylonitrile-co-allyl sulfonate),polyanionic polysaccharides,poly(biscarboxy-phenoxyphosphazene),poly(butylene oxide) (PBO),polycaprolactone (PCL),polyesters,poly(ethyl methacrylate) (PEMA),poly(ethylene glycol) (PEG),poly(ethylene glycol)-6CDs (PEG6CDs),polyethylene glycol-bis-(polylactic acid-acrylate) (PEG-bis-PLA-acrylate),polyethylene glycol-g-poly(acrylamide-co-vinylamine),polyethylene glycol-polycaprolactone-polyethylene glycol (PEG-PCL-PEG),polyethylene glycol-polylactic acid-polyethylene glycol (PEG-PLA-PEG),polyethylene glycol-polylactic-co-glycolic acid-polyethylene glycol (PEG-PLGA-PEG),poly(ethylene imine) (PEI),poly(ethylene oxide) (PEO),poly(glucosylethyl methacrylate) (PGEMA),poly(glucosylethyl methacrylate sulfate),poly(glycolic acid) (PGA),poly(hydroxypropyl methacrylamide-g-peptide) (poly(HPMA-g-peptide),poly(hydroxy butyrate) (PHB),poly(hydroxyethyl methacrylate) (PHEMA),poly(hydroxyethyl methylacrylate),poly(hydroxypropyl methacrylamide) (PHPMA),poly(lactic acid) (PLA),poly(lactic-co-glycolic acid) (PLGA),poly(lactic-co-glycolic acid-co-serine),polylactic acid-polyethylene glycol-polylactic acid (PLA-PEG-PLA),polylysine,poly(methacrylic acid-g-ethylene glycol),poly(methyl methacrylate) (PMMA),poly(methyl methacrylate-co-hydroxyethyl methacrylate),poly(N-2-hydroxypropyl methacrylamide),poly(N-isopropyl acrylamide-co-acrylic acid),poly(N-isopropyl acrylamide-co-ethylmethacrylate),poly(N-isopropyl acrylamide) (pNIPAAm),poly(N-vinyl pyrrolidone) (PNVP),poly(ethylene glycol/butylene oxide-terephthalate),poly(ethylene glycol-co-peptides),poly(propylene fumarate-co-ethylene glycol),polyphazene,poly(propylene oxide) (PPO),poly(vinyl acetate) (PVAc),poly(vinyl alcohol) (PVA),poly(vinyl amine),poly(vinyl methyl ether) (PVME),polyvinyl pyrrolidone,propylene fumarate (PF), andpullulan, or a combination thereof. 5. The polymer matrix according to claim 1, wherein said polymer matrix comprises at least one component selected from the group consisting of poly(amino acids), poly(anhydride), poly(caprolactone), poly(lactic acid), poly(lactic-glycolic acid), poly(hydroxybutyrate), poly(orthoesters), and poly(trimethylene carbonate). 6. The polymer matrix according to claim 1, wherein said polymer matrix comprises at least one component selected from the group consisting of latex, vinyl, polymers comprising vinyl groups, polyurethane urea, silicone, polyvinylchloride, polypropylene, styrene, polyurethane, polyester, copolymerisates of ethylene vinyl acetate, polystyrene, polycarbonate, polyethylene, polyacrylate, polymethacrylate, acrylonitrile butadiene styrene, polyamide, polyimide polytetrafluoroethylene, and polyparaphenyleneterephthalamide, or any combination thereof. 7. The polymer matrix according to claim 1, wherein said polymer matrix comprises at least one component selected from the group consisting of PEG, polyvinyl pyrrolidone, poly(urethane), dextran sulphate, heparin, collagen, poly(vinylmethylether), and poly(hydroxyethylmethacrylate). 8. A substrate at least partly coated with a polymer matrix according to claim 1. 9. The substrate according to claim 8, wherein the substrate comprises a material selected from the group consisting of stainless steel, medical grade steel, titanium, medical grade titanium, cobalt, chromium and aluminium or mixtures thereof. 10. The substrate according to claim 8, wherein the substrate comprises a material selected from the group consisting of glass, minerals, zeolites, stone and ceramics or a combination thereof. 11. The substrate according to claim 8, wherein the substrate comprises a material selected from the group consisting of paper, wood, woven fibres, fibres, cellulose fibres, leather, carbon, carbon fibres, graphite or a combination thereof. 12. A method of manufacturing a polymer matrix according to claim 1, comprising exposing said polymer matrix to at least one suspension comprising metal particles. 13. The method according to claim 12 wherein said polymer matrix is exposed to a first suspension comprising metal particles and subsequently exposed to a second suspension comprising metal particles, wherein said metal particles of said first suspension comprise silver, and said metal particles of said second suspension comprise palladium and gold. 14. The method according to claim 12 wherein said polymer matrix is exposed to one suspension comprising particles comprising silver and particles comprising palladium and gold. 15. The method according to claim 12 further comprising exposing said polymer matrix to a primer before exposing said polymer matrix to the at least one suspension comprising metal particles. 16. An article comprising a polymer matrix according to claim 1. 17. The article according to claim 16, wherein said article is selected from the group consisting of a medical device, a catheter, an endotracheal tube, a stent, a graft, a stent graft, a chromatography gel, a filter, an air filter, a water filter, a wound dressing, a mesh, a degradable bone fixation plug or screw, a degradable ligament implant, a tendon implant, a dental implant, a nerve guide, a medical instrument, a disposable article, a medical disposable article, a contact lens, a pacemaker, a pacemaker electrode, a stent, a dental implant, a rupture net, a rupture mesh, a blood centrifuge equipment, a surgical instrument, a glove, a blood bag, an artificial heart valve, a central venous catheter, a peripheral venous catheter, a vascular port, a haemodialysis equipment, a peritoneal dialysis equipment, a plasmapheresis device, an inhalation drug delivery device, a vascular graft, an arterial graft, a cardiac assist device, a wound dressing, an intermittent catheter, an ECG electrode, a peripheral stent, a bone replacing implant, an orthopaedic implant, an orthopaedic device, a tissue replacing implant, an intraocular lens, a suture, a needle, a drug delivery device, an endotracheal tube, a shunt, a drain, a suction device, and a hearing aid device. 18. The polymer matrix according to claim 1, wherein the metal particles have an average particle diameter of from about 100 to about 600 Å.
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이 특허에 인용된 특허 (20)
Ko, Tse Hao, Antimicrobial compositions and wound dressings.
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