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A medical device includes an antimicrobial layer. A method of depositing an antimicrobial agent on or in the body of a medical device includes inserting a high temperature resistant tube having multiple holes through its surface into a vascular access device and coating, or delivering an antimicrobi

A medical device includes an antimicrobial layer. A method of depositing an antimicrobial agent on or in the body of a medical device includes inserting a high temperature resistant tube having multiple holes through its surface into a vascular access device and coating, or delivering an antimicrobial agent to, and interior surface of the device.

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1. A medical device comprising: a body having an interior lumen;a septum housed within the interior lumen of the body, the septum having a slit to allow a separate extravascular device to access the interior lumen, wherein the septum includes an outer surface, an opening surface, a slit surface and

1. A medical device comprising: a body having an interior lumen;a septum housed within the interior lumen of the body, the septum having a slit to allow a separate extravascular device to access the interior lumen, wherein the septum includes an outer surface, an opening surface, a slit surface and an interior surface;a first coating material including an antimicrobial agent, disposed on at least one of the opening surface, the slit surface and the interior surface, the first coating material being soluble to a first flush compound and insoluble to a second flush compound, wherein the first coating material includes a solution containing a mixture of the antimicrobial agent and a lube oil, and wherein the first coating material is disposed on the slit surface of the septum; anda second coating material disposed on the first coating material, the second coating material being soluble to the second flush compound and insoluble to the first flush compound. 2. The medical device of claim 1, wherein the second coating is a lube oil. 3. The medical device of claim 1, wherein the first and second coating materials are disposed on at least two of the surfaces of the septum selected from the opening surface, the slit surface and the interior surface. 4. The medical device of claim 1, further comprising a plurality of alternating coating material layers disposed on at least one of the opening surface, the slit surface and the interior surface of the septum, wherein the coated septum surfaces comprise alternating layers of the first and second coating materials. 5. The medical device of claim 1, wherein the opening surface of the septum is coated with the first coating material, and wherein the first coating material is coated with the second coating material. 6. The medical device of claim 1, wherein the second coating material includes a fluorinated silicone. 7. The medical device of claim 1, wherein the opening surface, the slit surface and the interior surface form a contiguous contact surface of the septum. 8. A method of repressing pathogens in a vascular access device, comprising: providing a vascular access device comprising a body and a septum, the body having an interior lumen and the septum being housed within the interior lumen, the septum having a slit for providing access through the vascular access device, wherein the septum includes an outer surface, an opening surface, a slit surface and an interior surface;disposing a first coating material on at least one of the opening surface, the slit surface and the interior surface of the septum, the first coating material being soluble to a first flush compound and insoluble to a second flush compound, the first coating compound having an antimicrobial agent; anddisposing a second coating material on at least one of the opening surface, the slit surface and the interior surface of the septum, the second coating material being soluble to the second flush compound and insoluble to the first flush compound, wherein the second coating material includes a radioactive isotope. 9. The method of claim 8, further comprising disposing a plurality of alternating coating material layers on at least one of the opening surface, the slit surface and the interior surface of the septum, wherein the coated septum surface comprises alternating layers of the first and second coating materials. 10. The method of claim 8, further comprising disposing the first and second coating materials on at least two of the surfaces of the septum selected from the opening surface, the slit surface and the interior surface. 11. The method of claim 8, further comprising disposing the first and second coating materials to each of the opening surface, the slit surface and the interior surface of the septum. 12. The method of claim 8, wherein the second coating material includes a fluorinated silicone. 13. The method of claim 8, wherein the opening surface, the slit surface and the interior surface form a contiguous contact surface of the septum. 14. A medical device comprising: a body having an interior lumen;a septum housed within the interior lumen of the body, the septum having a slit to allow a separate extravascular device to access the interior lumen, wherein the septum includes an outer surface, an opening surface, a slit surface and an interior surface;a first coating material including an antimicrobial agent, disposed on at least one of the opening surface, the slit surface and the interior surface, the first coating material being soluble to a first flush compound and insoluble to a second flush compound; anda second coating material disposed on the first coating material, the second coating material being soluble to the second flush compound and insoluble to the first flush compound, wherein the second coating material includes a radioactive isotope.