IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0932781
(2011-03-04)
|
등록번호 |
US-8512679
(2013-08-20)
|
발명자
/ 주소 |
- Hyde, Roderick A.
- Wood, Jr., Lowell L.
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
24 |
초록
▼
Embodiments disclosed herein relate to thermostable storage of one or more therapeutic agents, including at least one detectable indicator. In an embodiment, the one or more therapeutic agents including at least one detectable indicator are included in at least one glassy substance. Also disclosed a
Embodiments disclosed herein relate to thermostable storage of one or more therapeutic agents, including at least one detectable indicator. In an embodiment, the one or more therapeutic agents including at least one detectable indicator are included in at least one glassy substance. Also disclosed are embodiments relating to delivery devices for administration of the thermostable therapeutic agents.
대표청구항
▼
1. A composition comprising: a glassy substance including at least one of sucrose, glucose, fructose, maltose, mannose, maltulose, iso-maltose, nigerose, cellubiulose, turanose, panose, isomaltotriose, stachyose, nystose, maltotetrose, maltopentose, maltohexose, malopheptose, ubombo sugar, raffinose
1. A composition comprising: a glassy substance including at least one of sucrose, glucose, fructose, maltose, mannose, maltulose, iso-maltose, nigerose, cellubiulose, turanose, panose, isomaltotriose, stachyose, nystose, maltotetrose, maltopentose, maltohexose, malopheptose, ubombo sugar, raffinose, arabinose, galactose, xylose, melibiose, salicin, arbutin, arabinose, adonitol, sorbose, thamnose, destrose, dulcitol, melezitose, gentiobiose, lyxose, tagatose, fucose, arabitol, or trehalose,a vaccine, anda moisture sensor including two components that react with each other upon degradation of the glassy substance; wherein the two components include ferric sulfate and tetrabutylammonium thiocyanate. 2. A composition comprising: a glassy substance including at least one of sucrose, glucose, fructose, maltose, mannose, maltulose, iso-maltose, nigerose, cellubiulose, turanose, panose, isomaltotriose, stachyose, nystose, maltotetrose, maltopentose, maltohexose, malopheptose, ubombo sugar, raffinose, arabinose, galactose, xylose, melibiose, salicin, arbutin, arabinose, adonitol, sorbose, thamnose, destrose, dulcitol, melezitose, gentiobiose, lyxose, tagatose, fucose, arabitol, or trehalose,insulin, anda detectable indicator of degradation of the glassy substance including the enzyme LDH. 3. The composition of claim 2, further including at least one detectable indicator includes at least one of phenol red, ethidium bromide, DNA polymerase, cobalt chloride, Reichardt's dye, a restriction endonuclease, or fluorogenic protease substrate. 4. The composition of claim 2, further including at least one carrier fluid. 5. The composition of claim 4, wherein the carrier fluid includes at least one phase of water, saline, intravenous fluid, or other fluid. 6. The composition of claim 2, further including at least one preservative. 7. The composition of claim 6, wherein the at least one preservative includes at least one enzyme inhibitor. 8. The composition of claim 6, wherein the at least one preservative includes at least one of validamycin A, TL-3, sodium orthovanadate, sodium fluoride, N-alpha-tosyl-Phe-chloromethylketone, N-alpha-tosyl-Lys-chloromethylketone, aprotinin, phenylmethylsulfonyl fluoride, diisopropylfluorophosphate, kinase inhibitor, phosphatase inhibitor, caspase inhibitor, granzyme inhibitor, cell adhesion inhibitor, cell division inhibitor, cell cycle inhibitor, lipid signaling inhibitor, protease inhibitor, reducing agent, alkylating agent, antimicrobial agent, oxidase inhibitor, or other inhibitor. 9. The composition of claim 6, wherein the preservative includes a cryoprotectant. 10. The composition of claim 2, further including at least one buffer. 11. The composition of claim 10, wherein the at least one buffer includes at least one of bicarbonate, monosodium phosphate, disodium phosphate, or magnesium oxide. 12. The composition of claim 2, wherein the composition includes at least two layers. 13. The composition of claim 12, wherein the at least two layers include at least one first glassy substance layer including the therapeutic agent that is different from at least one second glassy substance layer that includes the detectable indicator. 14. The composition of claim 2, wherein the at least one detectable indicator indicates degradation or disruption of the glassy substance by at least one of a change in color, change in opacity, or change in light scattering. 15. The composition of claim 1, further including at least one carrier fluid. 16. The composition of claim 15, wherein the carrier fluid includes at least one phase of water, saline, intravenous fluid, or other fluid. 17. The composition of claim 1, further including at least one preservative. 18. The composition of claim 17, wherein the at least one preservative includes at least one enzyme inhibitor. 19. The composition of claim 18, wherein the at least one preservative includes at least one of validamycin A, TL-3, sodium orthovanadate, sodium fluoride, N-alpha-toysl-Phe-chloromethylketone, N-alpha-tosyl-Lys-chloromethylketone, aprotinin, phenylmethylsulfonyl fluoride, diisopropylfluorophosphate, kinase inhibitor, phosphatase inhibitor, caspase inhibitor, granzyme inhibitor, cell adhesion inhibitor, cell division inhibitor, cell cycle inhibitor, lipid signaling inhibitor, protease inhibitor, reducing agent, alkylating agent, antimicrobial agent, oxidase inhibitor, or other inhibitor. 20. The composition of claim 1, further including at least one buffer. 21. The composition of claim 20, wherein the at least one buffer includes at least one of bicarbonate, monosodium phosphate, disodium phosphate, or magnesium oxide.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.