Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include
Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
대표청구항▼
1. An antimicrobial composition comprising: 0.1 wt-% to 20 wt-% of an antimicrobial lipid component comprising a (C7-C12)saturated fatty acid monoester of a polyhydric alcohol or an alkoxylated derivative thereof, a (C8-C22)unsaturated fatty acid monoester of a polyhydric alcohol or an alkoxylated d
1. An antimicrobial composition comprising: 0.1 wt-% to 20 wt-% of an antimicrobial lipid component comprising a (C7-C12)saturated fatty acid monoester of a polyhydric alcohol or an alkoxylated derivative thereof, a (C8-C22)unsaturated fatty acid monoester of a polyhydric alcohol or an alkoxylated derivative thereof, or combinations thereof, and the antimicrobial lipid component further includes no greater than 15 wt-%, based on the total weight of the antimicrobial lipid component, of a di- or tri-ester or an alkoxylated derivative thereof, a di- or tri-ether or an alkoxylated derivative thereof, or combinations thereof;0.01 wt-% to 20 wt-% of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof, wherein the total concentration of the enhancer component relative to the total concentration of lipid component is within a range of 10:1 to 1:300, on a weight basis;0.1 wt-% to 10 wt-% of a surfactant distinct from the antimicrobial lipid component, wherein the total concentration of the surfactant to the total concentration of antimicrobial lipid component is within a range of 5:1 to 1:100, on a weight basis;1 wt-% to 40 wt-% of a hydrophilic component that will dissolve or disperse in water at a temperature of 23° C. in an amount of at least 7% by weight, based on the total weight of the hydrophilic component and the water;50 wt-% to 95 wt-% of a hydrophobic component that will dissolve or disperse in water at a temperature of 23° C. in an amount of less than 5% by weight, based on the total weight of the hydrophobic component and the water; andless than 10 wt-% water; wherein the composition has at least 4 log reduction in test bacteria in 10 minutes when evaluated by the Antimicrobial Efficacy Test; and wherein the antimicrobial lipid component is different from the hydrophobic component. 2. The antimicrobial composition of claim 1, wherein the composition comprises: 1 wt-% to 10 wt-% of the antimicrobial lipid component;0.4 wt-% to 20 wt-% of the enhancer component, wherein the total concentration of the enhancer component relative to the total concentration of the antimicrobial lipid component is within a range of 5:1 and 1:10, on a weight basis;0.1 wt-% to 2 wt-% of the surfactant, wherein the total concentration of the surfactant to the total concentration of antimicrobial lipid component is within a range of 2:1 to 1:3, on a weight basis;10 wt-% to 40 wt-% of the hydrophilic component; andless than 2 wt-% water. 3. The antimicrobial composition of claim 2, wherein: the enhancer component comprises a carboxylic acid or an alpha-hydroxy acid;the surfactant comprises a sulfonate, a sulfate, a phosphonate, a phosphate, a poloxamer, a cationic surfactant, or mixtures thereof;the hydrophilic component comprises a glycol, a C1-C4 alcohol ether, a short chain alkyl ester, or combinations thereof, wherein the hydrophilic component is soluble in water in an amount of at least 20 wt-% at 23° C.; andthe hydrophobic component is an organic compound that is liquid, gelatinous, semisolid, or solid at 23° C. and has a solubility in water of less than 5 wt-% at 23° C.
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