State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
대리인 / 주소
Klarquist Sparkman, LLP
인용정보
피인용 횟수 :
10인용 특허 :
129
초록▼
Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system;
Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.
대표청구항▼
1. A fluid purification system having an inlet and an outlet, and defining a fluid flow pathway, comprising: a pump;a single fluid microfluidic pasteurizer downstream of the pump and coupled to the fluid flow pathway and configured to heat the fluid to a pasteurization temperature, maintain the flui
1. A fluid purification system having an inlet and an outlet, and defining a fluid flow pathway, comprising: a pump;a single fluid microfluidic pasteurizer downstream of the pump and coupled to the fluid flow pathway and configured to heat the fluid to a pasteurization temperature, maintain the fluid at the pasteurization temperature for a period of time effective to pasteurize fluid flowing through the pathway, and cool pasteurized fluid to a temperature lower than the pasteurization temperature; anda throttling valve downstream of the pasteurizer, wherein the pump and the throttling valve operate in a closed loop control setup to maintain the fluid at a desired pressure and flow rate as the fluid passes through the pasteurizer. 2. The fluid purification system of claim 1, wherein the pump is configured to increase the fluid pressure in the fluid flow pathway to a level higher than saturation pressure in the pasteurizer. 3. The fluid purification system of claim 1, wherein the desired pressure is at least a saturation pressure such that the fluid does not change state as the fluid passes through the pasteurizer. 4. The fluid purification system of claim 1, further comprising a filter upstream of the pasteurizer. 5. The fluid purification system of claim 4, where the filter is a carbon filter. 6. The fluid purification system of claim 1, further comprising a reverse osmosis element upstream of the pasteurizer. 7. The fluid purification system of claim 1, further comprising an ultra-filtration element downstream of the pasteurizer. 8. The fluid purification system of claim 1, further comprising a de-gassifier system downstream of the pasteurizer. 9. The fluid purification system of claim 1, wherein the fluid is water. 10. The fluid purification system of claim 1, further comprising a dialysate mixer that receives fluid from the outlet and mixes the fluid with dialysate components to form a dialysate. 11. The fluid purification system of claim 10, further comprising a dialyzer that receives dialysate from the dialysate mixer. 12. The fluid purification system of claim 1, further comprising: a reverse osmosis element upstream of the pasteurizer;an ultra-filtration element downstream of the pasteurizer; anda de-gassifier system downstream of the pasteurizer. 13. The fluid purification system of claim 1, further comprising a recirculation loop adapted to permit fluid leaving the fluid pathway to be recirculated back into the fluid pathway. 14. The fluid purification system of claim 13, further comprising a source of sterilizing fluid coupled to the recirculation loop. 15. A method for purifying a fluid, comprising: introducing a fluid stream into a fluid pathway;passing the fluid stream through a pump configured to achieve a predetermined fluid pressure in the fluid flow pathway;passing the fluid through a single fluid microfluidic pasteurizer that heats the fluid to a pasteurization temperature, maintains the fluid at the pasteurization temperature for a period of time effective to pasteurize the fluid, and cools pasteurized fluid to a temperature lower than the pasteurization temperature; andpassing the fluid stream through a throttling valve after the fluid exits the pasteurizer, wherein the pump and the throttling valve operate in a closed-loop to collectively maintain the fluid at a flow rate and pressure that inhibits the fluid from undergoing a phase change in the pasteurizer. 16. The method of claim 15 wherein the fluid is water. 17. The method of claim 16, further comprising passing the water stream through a filter. 18. The method of claim 17 where the filter is a carbon filter. 19. The method of claim 16, further comprising passing the water stream through a reverse osmosis element. 20. The method of claim 16, further comprising passing the water stream through a sediment filter. 21. The method of claim 16, further comprising passing the water stream through an ultra-filtration element. 22. The method of claim 16, further comprising passing the water stream through a de-gassifier. 23. The method of claim 16, further comprising passing the water stream in a pasteurized state to a dialysate mixer and mixing the pasteurized water stream with a dialysate component to produce dialysate. 24. The method of claim 23, further comprising passing the dialysate into a dialyzer. 25. The method of claim 16, further comprising passing the water stream through a reverse osmosis element, a sediment filter, an ultra-filtration element, a de-gassifier, a dialysate mixer to mix pasteurized water stream with a dialysate component to produce dialysate, and any and all combinations thereof. 26. The method of claim 16, comprising heating the water stream to at least 138° C. and maintaining the heated water stream in the pasteurizer at or above 138° C. for at least two seconds. 27. The method of claim 16, further comprising passing a sterilizing fluid through the fluid pathway prior to introducing the water stream into the fluid pathway. 28. The method of claim 27, further comprising heating at least a portion of the fluid pathway to heat sterilizing fluid flowing through the pathway to a desired fluid temperature, and thereafter introducing the water stream into the fluid pathway. 29. The method of claim 28, further comprising: reducing fluid temperature in the fluid pathway; andmaintaining a sterilizing fluid in the fluid pathway while the fluid temperature reduces. 30. The method of claim 29, wherein reducing fluid temperature in the fluid pathway comprises reducing the fluid temperature to room temperature. 31. The fluid purification system according to claim 1 wherein the microfluidic pasteurizer includes a residence chamber to receive the fluid for a predetermined residence time sufficient to pasteurize the fluid. 32. The fluid purification system according to claim 1 wherein the fluid is water, and the pump and the throttling valve operate to provide water in the system at a pressure of at least 485 kPa and a temperature of at least 138° C. 33. The fluid purification system according to claim 32 capable of producing water having 10−6 CFU/ml or less. 34. A fluid purification system having an inlet and an outlet, and defining a fluid flow pathway, comprising: a reverse osmosis element coupled to the fluid flow pathway;a pump downstream of the reverse osmosis element;a single fluid microfluidic pasteurizer downstream of the pump and coupled to the fluid flow pathway and configured to heat the fluid to a pasteurization temperature, maintain the fluid at the pasteurization temperature for a period of time effective to pasteurize fluid flowing through the pathway, and cool pasteurized fluid to a temperature lower than the pasteurization temperature;a throttling valve downstream of the microfluidic pasteurizer, wherein the pump and the throttling valve operate in a closed loop to maintain the fluid in the system at a desired pressure and flow rate selected for fluid pasteurization as the fluid passes through the microfluidic pasteurizer;an ultra-filtration element downstream of the throttling valve; andde-gassifier system downstream of the ultra-filtration element. 35. The fluid purification system of claim 34, further comprising a dialysate mixer that receives fluid from the outlet and mixes pasteurized fluid with dialysate components to form a dialysate. 36. The fluid purification system of claim 35, further comprising a dialyzer that receives dialysate from the dialysate mixer.
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