Nerve stimulation and blocking for treatment of gastrointestinal disorders
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/08
A61N-001/36
출원번호
US-0188293
(2011-07-21)
등록번호
US-8538542
(2013-09-17)
발명자
/ 주소
Knudson, Mark B.
Wilson, Richard R.
Tweden, Katherine S.
Conrad, Timothy R.
출원인 / 주소
EnteroMedics Inc.
대리인 / 주소
Merchant & Gould PC
인용정보
피인용 횟수 :
6인용 특허 :
128
초록▼
Systems and methods of using a system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ. A system comprises a first electrode adapted for placement on the vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastroi
Systems and methods of using a system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ. A system comprises a first electrode adapted for placement on the vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ, a second electrode adapted for placement on the vagus nerve at a site proximal to the stimulation site, a third electrode adapted for placement on the vagus nerve at a distal blocking site distal to the stimulation site, an implantable controller comprising at least one circuit for generating a neural conduction blocking signal connected to the second and third electrode, at least one circuit for generating a neural conduction stimulating signal connected to the first electrode; and an external programmer configured to communicate at least one parameter for the neural conduction blocking signal to the implantable controller; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couple to the implantable controller.
대표청구항▼
1. A system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ comprising: a first electrode adapted for placement on a vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ and below a diaphrag
1. A system for treating a gastrointestinal disorder characterized by dysmotility of a gastrointestinal organ comprising: a first electrode adapted for placement on a vagus nerve at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ and below a diaphragm of patient, anda second electrode adapted for placement on said vagus nerve at a site proximal to said stimulation site,a third electrode adapted for placement on said vagus nerve at a distal blocking site distal to said stimulation site,an implantable controller comprising an induction coil, at least one circuit for generating a neural conduction blocking signal connected to the second and third electrode, at least one circuit for generating a neural conduction stimulating signal connected to the first electrode, a battery, and a central processing unit comprising program storage and memory; andan external programmer configured to:communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neuroconduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output, andcommunicate at least one parameter for the neural conduction stimulating signal to the implantable controller, wherein the parameter is selected for the neuroconduction stimulating signal to enhance pancreatic and biliary output; andan external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couple to the induction coil of the implantable controller. 2. The system of claim 1, wherein the at least one parameter for the neural conduction blocking signal is selected from the group consisting of frequency, amplitude, pulse width, timing and duty cycle. 3. The system of claim 2, wherein the selected parameter is frequency. 4. The system of claim 3, wherein the frequency is at least 500 Hz. 5. The system of claim 2, wherein the selected parameter is the timing of the neural conduction blocking signal. 6. The system of claim 5, wherein the timing of the neural conduction blocking signal is intermittent. 7. The system of claim 2, wherein each blocking signal is applied concurrently with the stimulation signal. 8. The system of claim 1, wherein the first electrode is adapted to be placed on a vagal trunk. 9. The system of claim 8, wherein the vagal trunk innervates an organ selected from the group consisting of an esophagus, stomach, pancreas, duodenum, jejunum, and ileum. 10. The system of claim 1, wherein the at least one parameter for the neural conduction stimulating signal is selected from the group consisting of frequency, amplitude, pulse width, timing and duty cycle. 11. The system of claim 10, wherein the selected parameter is timing of the electrical signal. 12. The system of claim 11, wherein the stimulation signal is applied once every ten minutes. 13. The system of claim 10, wherein the stimulation signal has a frequency of 12 Hz. 14. The system of claim 1, wherein the vagus nerve comprises an anterior, a posterior, or anterior and posterior vagus nerves.
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