Compositions and methods for biological remodeling with frozen particle compositions
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-051/00
A61K-009/14
출원번호
US-0384212
(2009-03-31)
등록번호
US-8545806
(2013-10-01)
발명자
/ 주소
Boyden, Edward S.
Cook, Daniel B.
Hyde, Roderick A.
Leuthardt, Eric C.
Myhrvold, Nathan P.
Sweeney, Elizabeth A.
Wood, Jr., Lowell L.
출원인 / 주소
The Invention Science Fund I, LLC
인용정보
피인용 횟수 :
1인용 특허 :
125
초록▼
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particula
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
대표청구항▼
1. A frozen particle composition, comprising: one or more frozen solvent particles of at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrach
1. A frozen particle composition, comprising: one or more frozen solvent particles of at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, methane, toluene, chloroform, or diethyl ether, andincluding at least one biological remodeling agent of one or more of a transforming growth factor β family member, a bone morphogenetic protein, osteogenic protein, activin A, activin B, inhibin A, inhibin B, anti-mullerian hormone, or Nodal. 2. The frozen particle composition of claim 1, further including at least one of polyethylene glycol, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, HEPES-buffered saline, dextrose, or glucose. 3. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent includes one or more extracellular matrix components. 4. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is configured to promote growth of at least one biological tissue. 5. The frozen particle composition of claim 4, wherein the at least one biological remodeling agent is configured to promote at least partial construction or at least partial reconstruction of at least one biological tissue. 6. The frozen particle composition of claim 4, wherein the at least one biological remodeling agent is configured to provide at least one mechanical structure to the at least one biological tissue. 7. The frozen particle composition of claim 4, wherein the at least one biological remodeling agent is configured to provide oxygenation, nutrition, or other nourishment to the at least one biological tissue. 8. The frozen particle composition of claim 1, further including at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit. 9. The frozen particle composition of claim 8, wherein the detection material includes at least one electronic identification device. 10. The frozen particle composition of claim 9, wherein the at least one electronic identification device includes at least one radio frequency identification device. 11. The frozen particle composition of claim 8, wherein the detection material includes at least one radioactive element. 12. The frozen particle composition of claim 8, wherein the detection material includes at least one radioactive, luminescent, colorimetric or odorous substance. 13. The frozen particle composition of claim 8, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle. 14. The frozen particle composition of claim 1, formulated to be administered to at least one substrate. 15. The frozen particle composition of claim 14, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device. 16. The frozen particle composition of claim 1, formulated to be administered by one or more of topical administration, oral administration, enteral administration, mucosal administration, percutaneous administration, or parenteral administration. 17. The frozen particle composition of claim 1, formulated to be administered by high velocity impact. 18. The frozen particle composition of claim 1, formulated to be administered by one or more devices. 19. The frozen particle composition of claim 1, further including one or more of a reinforcement agent, therapeutic agent, abrasive, adhesive agent, or explosive material. 20. A frozen particle composition, comprising: one or more frozen solvent particles of at least one of acetone, ethyl acetate, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, hexamethylphosphorotriamide, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, methane, toluene, chloroform, or diethyl ether, andincluding at least one biological remodeling agent of one or more pegylated cytokine.
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이 특허에 인용된 특허 (125)
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