초록

Provided are medical articles (e.g., wound dressings) that include a pressure sensitive adhesive layer and methods of making the medical articles using immiscible materials that increase moisture vapor transmission rates.

대표청구항 ▼

1. A medical article comprising: a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA; andan MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is

1. A medical article comprising: a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA; andan MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups; wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid;wherein the MVTR-modifying material is incorporated within a scaffold that is in contact with the PSA layer. 2. The medical article of claim 1, wherein the PSA comprises a functional polymer, and wherein said polymer is prepared from at least 6 wt-% acidic- or basic-functional monomers, based on the total weight of the PSA. 3. The medical article of claim 1, wherein the PSA includes at least 1.8 mmoles acidic- or basic-functional groups per gram PSA. 4. The medical article of claim 1, wherein the PSA includes no greater than 4.2 mmoles acidic- or basic-functional groups per gram PSA. 5. The medical article of claim 1, further comprising a second PSA layer, wherein the MVTR-modifying material is disposed between the two PSA layers. 6. The medical article of claim 1, wherein the molar ratio of the MVTR-modifying material to the functional groups is 0.1:1 to 100:1. 7. The medical article of claim 1, wherein the PSA comprises basic-functional groups, and the MVTR-modifying material is acidic. 8. The medical article of claim 7, wherein the PSA comprises an amine polymer. 9. The medical article of claim 1, wherein the MVTR-modifying material improves the wet MVTR of the medical article by at least 20% relative to the same medical article without the MVTR-modifying material. 10. A medical article comprising: a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA;an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups; wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid; anda pH-altering layer, wherein the MVTR-modifying material is disposed between the PSA layer and the pH-altering layer, and wherein the pH-altering layer comprises a pH-altering material. 11. A medical article comprising: a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA;an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups; wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid; anda filtration layer, wherein the filtration layer is disposed between the MVTR-modifying material and a target site. 12. The medical article of claim 11, wherein the MVTR-modifying material is disposed on a surface of the PSA layer. 13. The medical article of claim 12, wherein the MVTR-modifying material is pattern coated onto the surface of the PSA layer. 14. A medical article comprising: a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA;an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups; wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid;a carrier film in contact with the PSA layer;an absorbent pad disposed between the carrier film and the adhesive layer; anda backing disposed between a support layer and the PSA layer, wherein the medical article is a wound dressing. 15. A medical article comprising: a PSA layer comprising a polymer having acid-functional groups, wherein the PSA includes at least 0.84 mmoles acidic-functional groups per gram PSA; anda basic MVTR-modifying material;wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid; andwherein the MVTR-modifying material comprises a base selected from a group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, lithium hydroxide, silver hydroxide, zinc hydroxide, ammonium hydroxide, magnesium hydroxide, barium hydroxide, strontium hydroxide, cesium hydroxide, rubidium hydroxide, ammonium carbonate, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, silver carbonate, lithium carbonate, lithium bicarbonate, barium bicarbonate, magnesium carbonate, cesium carbonate, hydrates thereof, and combinations thereof. 16. The medical article of claim 15, wherein the PSA comprises rubber based adhesives, (meth)acrylics, poly(alpha-olefin)s, polyurethane, silicones, and combinations thereof. 17. A wound dressing comprising: a backing having a first major surface and a second major surface;a PSA layer disposed on at least a portion of the first major surface of the backing; wherein the PSA comprises acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA; andan MVTR-modifying layer proximate the PSA layer; wherein the MVTR-modifying layer comprises a scaffold;wherein the MVTR-modifying layer comprises an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups, or is acidic when the PSA comprises basic-functional groups; andwherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups to form a poly-salt upon contact in the presence of fluid. 18. The wound dressing of claim 17, wherein the PSA comprises basic amine groups. 19. A wound dressing comprising: a backing having a first major surface and a second major surface;a PSA layer disposed on at least a portion of the first major surface of the backing;wherein the PSA comprises acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA;an absorbent layer, wherein the absorbent layer comprises a polymeric fabric, a polymeric foam, or a combination thereof; andan MVTR-modifying layer proximate the PSA layer; wherein the MVTR-modifying layer comprises an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups, or is acidic when the PSA comprises basic-functional groups;wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups to form a poly-salt upon contact in the presence of fluid. 20. The wound dressing of claim 19, wherein the MVTR-modifying layer is in direct contact with at least a portion of the PSA layer. 21. The wound dressing of claim 19, wherein the PSA comprises carboxylic acid groups. 22. The wound dressing of claim 21 wherein the MVTR-modifying material comprises a base selected from a group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, lithium hydroxide, silver hydroxide, zinc hydroxide, ammonium hydroxide, magnesium hydroxide, barium hydroxide, strontium hydroxide, cesium hydroxide, rubidium hydroxide, ammonium carbonate, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, silver carbonate, lithium carbonate, lithium bicarbonate, barium bicarbonate, magnesium carbonate, cesium carbonate, hydrates thereof, and combinations thereof. 23. A wound dressing comprising: a backing having a first major surface and a second major surface;a PSA layer disposed on at least a portion of the first major surface of the backing; wherein the PSA layer comprises acid-functional groups;a support layer releasably adhered to the second major surface of the backing; andan MVTR-modifying layer comprising an MVTR-modifying material in contact with the PSA layer, wherein the PSA layer does not include MVTR-modifying material uniformly dispersed throughout;wherein the MVTR-modifying material is basic, is immiscible with the PSA, and reacts with the functional groups to form a poly-salt upon contact in the presence of fluid. 24. The wound dressing of claim 23, wherein the PSA includes at least 0.84 mmoles acidic-functional groups per gram PSA. 25. The wound dressing of claim 23, wherein the polymer is prepared from at least 6 wt-% acidic-functional monomers, based on the total weight of the PSA. 26. A method of increasing the moisture vapor transmission rate of an adhesive layer in a medical article, the method comprising: providing a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.84 mmoles acidic- or basic-functional groups per gram PSA;providing an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups, wherein the MVTR-modifying material is immiscible with the PSA; andplacing the MVTR-modifying material in the medical article at a location that allows the MVTR-modifying material to contact the PSA when the medical article comes in contact with fluid during use;wherein contact between the MVTR-modifying material, the PSA, and fluid causes an acid-base reaction to form a poly-salt and increase the moisture permeability of at least a portion of the PSA layer. 27. The method of claim 26, wherein the polymer is prepared from at least 6 wt-% acidic- or basic-functional monomers, based on the total weight of the PSA. 28. The method of claim 26, wherein placing the MVTR-modifying material in the medical article at a location that allows the MVTR-modifying material to contact the PSA includes coating the MVTR-modifying material onto the PSA layer. 29. The method of any one of claims 26 through 28 placing the MVTR-modifying material in the medical article at a location that allows the MVTR-modifying material to contact the PSA includes: providing a scaffold;coating the scaffold with the MVTR-modifying material; andcontacting at least a portion of the PSA layer with the coated scaffold.