Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass
Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.
대표청구항▼
1. A bone graft composition comprising: about 15% to about 20% by weight collagen; about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate, wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said
1. A bone graft composition comprising: about 15% to about 20% by weight collagen; about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate, wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft composition, and wherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm. 2. The bone graft composition of claim 1, wherein said collagen is medical grade type I collagen. 3. The bone graft composition of claim 1, wherein said calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite. 4. The bone graft composition of claim 3, further comprising about 15% by weight medical grade type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate. 5. The bone graft composition of claim 4, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively. 6. The bone graft composition of claim 4, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively. 7. The bone graft composition of claim 4, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively. 8. A bone graft composition, comprising: an uncompressed collagen, the collagen comprising about 15% by weight of the bone graft composition; a plurality of bioactive glass particles dispersed throughout the collagen, at least 85% of the plurality of bioactive glass particles within a range of 212 μm to about 425 μm, the plurality of bioactive glass particles comprising about 60% by weight of the bone graft composition; and a calcium phosphate dispersed throughout the collagen and the calcium phosphate material comprising about 20% to 30% by weight of the bone graft composition. 9. The bone graft composition of claim 8, wherein the calcium phosphate is 25% to 30% by weight of the bone graft composition. 10. The bone graft composition of claim 8, wherein the calcium phosphate is 30% by weight of the bone graft composition. 11. A bone graft composition, comprising: a collagen matrix; and a plurality of bioactive glass particulates dispersed throughout said collagen matrix, at least 85% of the plurality of bioactive glass particulates having a size within a range of 212 μm to about 425 μm; wherein said collagen matrix is about 20% to about 60% by weight of the bone graft composition and said bioactive glass is about 40% to about 80% by weight of the bone graft composition. 12. The bone graft composition of claim 11, wherein said collagen matrix is uncompressed. 13. The bone graft composition of claim 11, further comprising: a calcium phosphate dispersed throughout said collagen matrix, the calcium phosphate is 25% to 30% by weight of the bone graft composition;the plurality of bioactive glass particulates are 50% by weight of the bone graft composition. 14. The bone graft composition of claim 13, wherein the collagen is about 20% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 80% by weight of the bone graft composition. 15. The bone graft composition of claim 13, wherein the collagen is about 40% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 60% by weight of the bone graft composition. 16. The bone graft composition of claim 13, wherein the collagen is about 60% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 40% by weight of the bone graft composition. 17. The bone graft composition of claim 11, wherein the collagen and the plurality of bioactive glass particulates collectively comprise 100% by weight of the bone graft composition. 18. A method of making a porous bone graft material of claim 1, comprising the steps of: a) mixing a collagen with bioactive glass particles and calcium phosphate; andb) lyophilizing the mixture of said collagen, bioactive glass particles, and calcium phosphate to form a porous bone graft material,wherein the lyophilized bone graft material is about 15% to about 20% by weight collagen;about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate,wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft material, andwherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm. 19. The method of claim 18, wherein said collagen is type I collagen. 20. The method of claim 18, wherein said calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite. 21. The method of claim 20, further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate. 22. The method of claim 21, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively. 23. The method of claim 21, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively. 24. The method of claim 21, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively. 25. A method of making bone graft material of claim 1, comprising the steps of: mixing a collagen with calcium phosphate;lyophilizing the mixture of collagen and calcium phosphate to form a porous bone graft material; anddisposing, after the lyophilizing, the bioactive glass onto the bone graft material wherein the bone graft material is about 15% to about 20% by weight collagen; about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate,wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft material, andwherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm. 26. The method of claim 25, wherein the disposing includes wetting the bone graft material with a solution including the bioactive glass. 27. The method of claim 25, wherein the disposing includes sprinkling the bioactive glass particles onto the bone graft material. 28. The method of claim 25, further comprising wetting, after the lyophilizing, the porous bone graft material, wherein the disposing occurs after the wetting.
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