IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0966962
(2010-12-13)
|
등록번호 |
US-8556834
(2013-10-15)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
9 인용 특허 :
272 |
초록
▼
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activa
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
대표청구항
▼
1. A treatment method, comprising: placing a therapeutic ultrasonic energy source comprising a transducer external to a patient;controlling the transducer using information from an imaging device to deliver ultrasonic energy from outside the patient to a target region containing a nerve next to a bl
1. A treatment method, comprising: placing a therapeutic ultrasonic energy source comprising a transducer external to a patient;controlling the transducer using information from an imaging device to deliver ultrasonic energy from outside the patient to a target region containing a nerve next to a blood vessel, wherein the transducer is controlled to deliver the ultrasonic energy to different positions three-dimensionally around a reference position in the blood vessel, wherein the different positions are arranged approximately in a spherical or ellipsoidal configuration;tracking the blood vessel to update a position of the target region containing the nerve; andadjusting the delivery of the ultrasonic energy from outside the patient to the target region in response to the updated position of the target region. 2. The method of claim 1, wherein the transducer is controlled to create a heat zone having an annular configuration. 3. The method of claim 1, wherein the transducer is controlled to treat tissue that is at least ten millimeters away from the blood vessel. 4. The method of claim 1, wherein the transducer is controlled to treat tissue that comprises an adventitia surrounding the blood vessel. 5. The method of claim 1, wherein the target region is an autonomic nerve region, and the blood vessel leads to a kidney; and wherein the ultrasonic energy is delivered through a path from an external position posterior to the patient, the path intersecting the kidney while avoiding bone and bowel tissue. 6. The method of claim 1, wherein the reference position is at a center of the blood vessel, and one of the positions that are three-dimensionally around the reference position in the blood vessel is offset from the center of the blood vessel. 7. The method of claim 1, wherein the transducer is controlled to deliver the ultrasonic energy to a carotid body or a carotid sinus. 8. A medical method, comprising: detecting a blood vessel using a doppler flow signal;applying heat to a nerve region outside the blood vessel by delivering energy from outside a patient's body to different positions around a reference position in the blood vessel, wherein the different positions are arranged approximately in a spherical or ellipsoidal configuration;determining an effect of the heat being applied to the nerve region using an ultrasound signal, wherein the effect corresponds with a change in a tissue property at the nerve region outside the blood vessel. 9. The method of claim 8, wherein the heat is applied to tissue in the nerve region on at least two sides of the blood vessel. 10. The method of claim 8, wherein the act of applying heat comprises creating a zone of heat surrounding the blood vessel to create an annular region around the blood vessel to inhibit nerves surrounding the blood vessel. 11. The method of claim 8, further comprising creating a map that represents the effect of the heat. 12. The method of claim 8, further comprising modifying the application of heat in response to the determined effect of the heat. 13. The method of claim 8, wherein the effect comprises tissue elasticity. 14. The method of claim 8, wherein the effect comprises temperature. 15. The method of claim 8, further comprising altering an amount of the heat being applied through application of the energy in response to the change in the tissue property. 16. The method of claim 8, wherein the reference position is at a center of the blood vessel, and one of the positions that are three-dimensionally around the reference position in the blood vessel is offset from the center of the blood vessel. 17. The method of claim 8, wherein the heat is applied to a carotid body or a carotid sinus. 18. A treatment method, comprising: obtaining a first signal associated with a first position of a blood vessel;controlling a transducer at a location external to a patient to deliver ultrasonic energy to different positions three-dimensionally around the first position of the blood vessel to thereby treat a first nerve next to the blood vessel, wherein the different positions are arranged approximately in a spherical or ellipsoidal configuration;obtaining a second signal associated with a second position of the blood vessel;adjusting the delivery of the ultrasonic energy based on the second signal. 19. The method of claim 18, wherein the first signal is obtained from a fiducial located inside the blood vessel. 20. The method of claim 18, wherein the delivery of the ultrasonic energy is adjusted by changing a position of a focal point of the ultrasonic energy. 21. The method of claim 18, wherein the first nerve is at a first side of the blood vessel, and the ultrasonic energy is also delivered to treat a second nerve at a second side of the blood vessel. 22. The method of claim 18, wherein the transducer is controlled to create a heat zone having an annular configuration. 23. The method of claim 18, wherein the ultrasonic energy is delivered to the first nerve by aiming a focal point of the ultrasonic energy away from the first position of the blood vessel. 24. The method of claim 18, wherein the first signal comprises a Doppler flow signal. 25. The method of claim 18, wherein the first nerve comprises an autonomic nerve. 26. The method of claim 25, wherein the ultrasonic energy is delivered through a path from an external position posterior to the patient, the path intersecting a kidney while avoiding bone and bowel tissue. 27. The method of claim 18, wherein the first position of the blood vessel is a center of the blood vessel, and one of the positions that are three-dimensionally around the first position of the blood vessel is offset from the center of the blood vessel. 28. The method of claim 18, wherein the transducer is controlled to deliver the ultrasonic energy to a carotid body or a carotid sinus.
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