[특허]Water-swellable polymers

[미국특허] Water-swellable polymers 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/11
출원번호	US-0835436 (2010-07-13)
등록번호	US-8557281 (2013-10-15)
우선권정보	GB-0222522.5 (2002-09-27)
발명자 / 주소	Halliday, Janet A. Tuominen, Jukka Livingstone, Mark Koppenhagen, Frank Currie, Lilias Stewart, Sarah
출원인 / 주소	Ferring B.V.
대리인 / 주소	Fish & Richardson P.C.
인용정보	피인용 횟수 : 19 인용 특허 : 264

초록

A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.

대표청구항 ▼

1. A pharmaceutical controlled release composition in solid dosage form, comprises: (I) a water-swellable linear polymer obtainable by reacting (a) a polyethylene oxide;(b) a C8 to C15 alkanediol; and(c) a diisocyanate; and(II) a releasable pharmaceutically active agent; wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000 and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5. 2. A composition according to claim 1 wherein the molecular weight of the active agent is in the range 200 to 20,000. 3. A composition according to claim 1 wherein the active agent is a prostaglandin. 4. A composition according to claim 1 wherein the active agent is terbutaline sulphate, clindamycin sulphate, oxytocin, misoprostol or progesterone. 5. A composition according to claim 1 in the form of a suppository, pessary, buccal insert or film. 6. A composition according to claim 1 wherein the polyethylene oxide has a number average molecular weight of 4000 to 35,000. 7. A composition according to claim 1 wherein the polyethylene oxide has a number average molecular weight of 8000 to 12,000. 8. A composition according to claim 1 wherein the diol is 1,10-decanediol. 9. A composition according to claim 1 wherein the diol is 1,12-dodecanediol. 10. A composition according to claim 1 wherein the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.2-0.9 to 1 to 1.2-1.9. 11. A composition according to claim 1 wherein the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.5-0.9 to 1 to 1.5-1.9. 12. A composition according to claim 1 wherein the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-0.9 to 1 to 1.1-1.9. 13. A composition according to claim 1 which is swellable in water up to 500%. 14. A composition according to claim 1 which is swellable in water up to 1700%. 15. A composition according to claim 1 which is soluble in dichloromethane. 16. A composition according to claim 1 wherein the molecular weight of the active agent is up to 200,000. 17. A method of making the composition of claim 1, which comprises reacting together components (a), (b) and (c) to produce the water-swellable linear polymer, and contacting the polymer with the releasable pharmaceutically active agent. 18. The method of claim 17, wherein the contacting step comprises contacting the polymer with an aqueous solution containing the pharmaceutically active agent to form a hydrogel. 19. The method of claim 18, further comprising drying the hydrogel to form the pharmaceutical controlled release composition. 20. A pharmaceutical controlled release composition in solid dosage form, comprising: (I) a water-swellable linear polymer obtained by reacting (a) a polyethylene oxide;(b) a C5 to C20 alkanediol; and(c) a diisocyanate; and(II) a releasable pharmaceutically active agent;wherein the water-swellable linear polymer has a water swelling percentage of 250% to 2000%, wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000, and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5. 21. The composition of claim 18, wherein the water-swellable linear polymer has a water swelling percentage of 250% to 1700%. 22. The composition of claim 18, wherein the water-swellable linear polymer has a water swelling percentage of 300% to 1700%. 23. A pharmaceutical controlled release composition in solid dosage form, consisting of: (I) a water-swellable linear polymer obtained by reacting (a) a polyethylene oxide;(b) a C5 to C20 alkanediol; and(c) a diisocyanate; and(II) a releasable pharmaceutically active agent; wherein the water-swellable linear polymer is a random copolymer and the dosage form is a pessary or suppository, wherein the polyethylene oxide has a number average molecular weight of 3000 to 40,000, and the ratio of components (a) to (b) to (c) in terms of equivalent weights is in the range 0.1-1.5 to 1 to 1.1-2.5.

이 특허에 인용된 특허 (264) 인용/피인용 타임라인 분석

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Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
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Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
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Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
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Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
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Neal Gary W., Methods for treating male erectile dysfunction.
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Luo Ming, Methods of inhibiting bacterial sialidase.
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Fritz Hostettler ; Peter Wachtel, Methods of preparing polyurethane adhesives, adhesives produced thereby and medical devices employing the same.
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Bockman Richard S. (22 Spring St. Sag Harbor NY 11963), Methods of protecting and preserving connective and support tissues.
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Neal, Gary W., Methods, compositions, and kits for enhancing female sexual desire and responsiveness.
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Ishii Seiji (Yokohama JPX) Miyoshi Masanori (Yokohama JPX) Ishiwaka Takumi (Yokohama JPX) Kondo Osamu (Yokohama JPX), Microcellular polyurethane elastomer and manufacturing method of the same.
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Graham Neil Bonnette,GBX ; Mao Jianwen,DEX, Microgels.
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Zaffaroni Alejandro (Atherton CA), Microporous drug delivery device.
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Krebs Michael,DEX ; Heider Roland,DEX ; Schillings Klaus,DEX ; Gansow Michael, Moisture curing polyurethane hot-melt adhesive.
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Zenda Tatsuya (Ishikawa JPX) Hayashi Yutaka (Ishikawa JPX) Kitagawa Motoaki (Hikone JPX) Seino Takashi (Shiga JPX), Moisture-permeable waterproof fabric and process for production thereof.
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Del Soldato, Piero; Benedini, F{overscore (r)}ancesca; Antognazza, Patrizia, Nitrate salts of antimicrobial agents.
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Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
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Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
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Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
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El-Rafaey, Hazem, Oral or vaginal administration of mesoprostol in third stage labor.
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Janet Anne Halliday GB; Steven Robertson GB, Oral transmucosal delivery.
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Higuchi Takeru (Lawrence KS) Leeper Harold M. (Mountain View CA), Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient.
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Zaffaroni ; Alejandro ; Michaels ; Alan S. ; Theeuwes ; Felix, Osmotic releasing device having a plurality of release rate patterns.
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Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (Atherton CA) Theeuwes Felix (Los Altos CA), Osmotic releasing device having a plurality of release rate patterns.
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Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (Atherton CA) Theeuwes Felix (Los Altos CA), Osmotic releasing system for administering ophthalmic drug to eye of animal.
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Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (San Francisco CA) Theeuwes Felix (Los Altos CA), Osmotic releasing system with means for changing release therefrom.
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Yoshikawa Hirofumi,JPX ; Sasaki Hideki,JPX ; Seki Junzo,JPX, PGE.sub.1 -containing-freeze dried preparation and process for the production thereof.
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Deffeyes Robert J. (Arlington TX), Package having dessicant composition.
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Rosenthale Marvin E. (Princeton NJ) Shriver David A. (Martinsville NJ) Katz Laurence B. (Lawrenceville NJ), Peptic ulcer treatment method.
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Vulpescu, Dan-Gabriel; Freudensprung, Brigitte, Pharmaceutical composition.
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Prisell Per (Wollmar Yxkullsgatan 15A S-116 50 Stockholm SEX) Norstedt Gunnar (Foerfattavaegen 46 S-116 42 Bromma SEX), Pharmaceutical preparation.
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Kwee Bobby L. S. (JV OSS NLX) Egberink Johannes G. J. (EB OSS NLX), Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension.
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Hisayuki Kayanoki JP; Fujio Sawaragi JP, Plastic lenses and primer composition used for coating the same.
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Tremont Samuel J., Polyamines and method for preparation thereof.
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Tremont Samuel J. (Manchester MO), Polyamines and method for preparation thereof.
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Tremont Samuel J. (Manchester MO), Polyamines and method for preparation thereof.
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Tremont Samuel J. (Manchester MO), Polyamines and method for preparation thereof.
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Kohno Kenji (Nagaokakyo JPX) Nagataki Yoshiyuki (Osaka JPX) Miyata Kazushi (Osaka JPX) Higashi Hiroshi (Osaka JPX), Polycarbonate polyol, aromatic polycarbonate polyurethane resin, coating agent, cast film, magnetic recording medium.
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Piccirilli Robert M. (Pittsburgh PA) Chang Wen-Hsuan (Gibsonia PA) McKeough David T. (Gibsonia PA) Porter ; Jr. Samuel (Natrona Heights PA), Polyester coating composition.
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Peerman Dwight (Minnetonka MN), Polyester polyols from bishydroxymethyl tricyclo compounds and caprolactone and polyurethanes based thereon.
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Koyama Yoshiyuki (Noda JPX) Kojima Shuji (Kashiwa JPX) Miyazaki Tsuyoshi (Tsukuba JPX) Suginaka Akinori (Chigasaki JPX) Matsumoto Takeo (Tsukuba JPX) Murata Yoshishige (Tsukuba JPX), Polymer-drug conjugate and a method of producing it.
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Tremont Samuel J. ; Collins Paul Waddell ; Perkins William Eldredge ; Jones Peter Hadley, Polymeric drug delivery system.
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Lee Jung-Chung ; Pushpala Shamim ; Lee Charles E., Polymeric microporous film coated subcutaneous implant.
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Hoy Kenneth L. (St. Albans WV) Hoy Richard C. (South Charleston WV), Polymers with hydrophobe bunches.
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Watanabe Shoji (Ohtake JPX) Miho Takuya (Ohtake JPX), Polyurethane.
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Moeller, Thomas; Gensch, Ingo; Fischer, Herbert; Huebner, Norbert; Plum, Hermann-Josef; Herlfterkamp, Bernhard, Polyurethane adhesive.
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Bailey ; Brian Edward ; Bunker ; Anthony John, Polyurethane adhesives having high peel strength at 70.degree. C.
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Muhlfeld, Horst; Wagener, Silke, Polyurethane molding mass that can be processed thermoplastically.
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Menovcik Gregory L. (Farmington Hills MI) Ohrbom Walter H. (Commerce MI), Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition.
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Menovcik Gregory L. ; Ohrbom Walter H., Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition.
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Menovcik Gregory L. ; Ohrbom Walter H., Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition.
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Menovcik Gregory L. ; Ohrbom Walter H., Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition.
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Julia Barges Joaquim,ESX ; Ayuso Piqueras Jose Luis,ESX, Polyurethane thermoplastic material and production process.
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Fisch Herbert (Wachenheim DEX) Maempel Lothar (Bruehl DEX) Volkert Otto (Weisenheim DEX), Preparation of emulsifier-free aqueous polyurethane dispersions.
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Matsumoto Yukio (Yokohama JPX) Kunii Nobuaki (Yokohama JPX), Prepolymer composition utilizing polyol combination for production of coatings and films.
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Wong Patrick S. (Palo Alto CA), Process for making drug delivery device with reservoir.
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Kondo Kanemitu (Okazaki JPX) Nomura Takao (Toyota JPX) Ukai Junzo (Toyota JPX) Isaka Takuji (Kyoto JPX) Ishikawa Isao (Kyoto JPX) Nagata Kouzaburo (Kyoto JPX), Process for producing polyurethane.
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Matier William L. (Hockessin DE) Woo Chi (Libertyville IL) Lee Ying-Chi (Libertyville IL), Process for the preparation of clindamycin phosphate.
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Schpel Dieter (Cologne DEX), Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecula.
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Gass Bruno,CAX, Projection welded panel spacer and method for making the same.
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Gass, Bruno, Projection welded panel spacer and method for making the same.
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Frlich Jrgen (Rhrichtweg 11 3000 Hannover 71 DEX) Bippi Herbert (Wolfratshauser Str. 35 8032 Pullach DEX), Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compoun.
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Frolich Jurgen C.,DEX ; Bippi Herbert,DEX, Prostaglandin E1 derivatives as pharmacologically active agents, especially for transcutaneous administration.
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Frlich Jrgen C. (Rhrichtweg 11 3000 Hannover 71 DEX) Bippi Herbert (Warburghof 10B 3000 Hannover 61 DEX), Prostaglandin E1 derivatives for transdermal administration and methods of treatment therewith.
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Yeager James L. ; Buyuktimkin Nadir ; Buyuktimkin Servet, Prostaglandin compositions and methods of treatment for male erectile dysfunction.
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Yeager, James L.; Buyuktimkin, Nadir; Buyuktimkin, Servet, Prostaglandin compositions and methods of treatment for male erectile dysfunction.
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Hanson Wayne R. (Oak Park IL), Protective prostaglandins for use in conjunction with chemotherapeutic agents.
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Hanson Wayne R. (Oak Park IL), Protective prostaglandins for use in conjunction with chemotherapeutic agents.
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Hanson Wayne R. (Oak Park IL), Protective prostaglandins for use in conjunction with chemotherapeutic agents.
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Mller Hanns-Peter (Odenthal DEX) Dhein Rolf (Krefeld DEX) Hugl Herbert (Bergisch Gladbach DEX) Pudleiner Heinz (Krefeld DEX), Pure, in particular catalyst-free polyurethanes.
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Park Kisoon (Charleston WV), Radiation-curable allyl- or vinyl capped polycaprolactone compositions.
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Stobbie ; IV Charles W. (Woodbury MN) Tangen John C. (St. Paul MN), Reactive wax-containing moisture curable hot melt composition.
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Burns Patrick J., Regulation of estrus and ovulation in gilts.
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de Nijs Henrik (Oss NLX), Release system for two or more active substances.
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Quigley ; Jr. John W. (Foster City CA) Goodman Harris (San Francisco CA), Retinoic acid-containing compositions.
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Quigley ; Jr. John W. (Foster City CA) Goodman Harris (San Francisco CA), Retinoic acid-containing polyether-polyurethane compositions.
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MacDonald Ishbel A. (Glasgow GB6) Muddle Andrew G. (Strathaven GB6) MacFarlane Lindesay R. (Glasgow GB6), Retrievable pessary.
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Thomas Heinrich Sieker DE; Franco Gabrieli IT; Saskia Rachel Walraedt BE, Rigid polyurethane foams.
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Oriani Steven R. (Houston TX), Rigid thermoplastic plyurethane comprising units of butane diol and a polyethylene glycol.
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Kawata Terushige (Tokushima JPX) Yamashita Shinsuke (Tokushima JPX), Sheet-shape adhesive preparation.
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Kawata Terushige (Tokushima JPX) Yamashita Shinsuke (Tokushima JPX), Sheet-shape adhesive preparation.
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Kararli Tugrul T. ; Otto David ; Penzotti ; Jr. Stanley C. ; Truelove James E., Stabilized dispersions of misoprostol.
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Wagner Julie Ann ; Zukowski Joseph Michael ; Robinson Larry Richard ; Deckner George Endel ; Rinaldi Marie Antoinette ; Szymanski Victoria Claire, Stable topical compositions.
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Sterrett Terry L. (Long Beach CA), Stain-resistant orthodontic device.
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Beckett, Christian Westy; Eliasen, Per Robert Topp, Suppository and composition comprising at least one polyethylene glycol.
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Riffle Judy S., Surface-modifying copolymers having cell adhesion properties.
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Damani Nalinkant C. (Cincinnati OH), Sustained release compositions for treating periodontol disease.
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Friedman Michael,ILX ; Kohen Ron,ILX, Sustained-release pharmaceutical system for the delivery of antioxidants.
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Livingston Douglas A. (Kalamazoo MI), Synthesis of 7-halo-7-deoxylincomycins.
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Martin Alain (31 Country Club Dr. Ringoes NJ 08551), Therapeutic-wound healing compositions and methods for preparing and using same.
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Gould Francis E. (Princeton) Johnston Christian W. (Neshanic Station) Seems George E. (Pennington NJ), Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses.
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Karakelle Mutlu (Dayton OH) Solomon Donald D. (Spring Valley OH), Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter.
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Pudleiner Heinz,DEX ; Dujardin Ralf ; Hobler Hartwin,DEX, Thermoplastic polyurethanes containing active substances.
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Dewanjee, Pijush K., Thermosetting polyurethane material for a golf ball.
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Ayer Donald E. (Kalamazoo MI) Schlagel Carl A. (Kalamazoo MI) Flynn Gordon L. (Ann Arbor MI), Topical clindamycin preparations.
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Servet Buyuktimkin ; Nadir Buyuktimkin ; James L. Yeager, Topical compositions containing prostaglandin E1.
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Buyuktimkin Servet ; Buyuktimkin Nadir ; Yeager James, Topical compositions for prostaglandin E.sub.1 delivery.
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Mo, Y. Joseph; Frank, Daniel W., Topical stabilized prostaglandin E compound dosage forms.
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Hsieh Dean, Transdermal and trans-membrane delivery compositions.
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Hseih Dean (Brandamore PA), Transdermal and trans-membrane delivery of drugs.
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Seeger Nelson V. (Cuyahoga Falls OH) Kaman Andrew J. (Norton OH), Transparent, impact-resistant polyesterurethane laminates.
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Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
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Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
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Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
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Virgil A. Place ; Leland F. Wilson ; Paul C. Doherty, Jr. ; Mark S. Hanamoto ; Alfred P. Spivack ; Neil Gesundheit ; Sean R. Bennett, Treatment of female sexual dysfunction using phosphodiesterase inhibitors.
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Pascault Jean Pierre (Villeurbanne FRX) Cuve Lon (Lyon FRX), Urethane polymer composition and preparation of articles from these polymers.
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Joseph William D. ; Pavelka Lee A., Urethane/acrylate bead bond for retroreflective articles.
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Son Nguyen Kim DE; Axel Sanner DE; Karin Sperling-Vietmeier DE; Peter Hoessel DE, Use of cationic polyurethanes and polyureas as ingredients of cosmetic preparations.
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Kanakaris Panagiotis,GRX ; Karouzakis Petros,GRX, Use of misoprostol or/and misoprostol acid for diagnosis of vascular damage in a subject with erectile dysfunction.
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Leonardi Amedeo,ITX ; Motta Gianni,ITX ; Testa Rodolfo,ITX ; Sironi Giorgio,ITX, Use of selective antagonists of the .alpha.1B-adrenergic receptor for improvement of sexual dysfunction.
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Leonardi, Amedeo; Motta, Gianni; Testa, Rodolfo; Sironi, Giorgio, Use of selective antagonists of the α1B-adrenergic receptor for improvement of sexual dysfunction.
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Kim Son Nguyen,DEX ; Sanner Axel,DEX ; Kolter Karl,DEX, Use of water-soluble or water-dispersible polyurethanes as coatings or binders for pharmaceutical presentations.
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Wong Patrick S. (Palo Alto CA), Vaginal contraceptive system made from block copolymer.
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Harrison, Donald C.; Liu, James H.; Pauletti, Giovanni M.; Ritschel, Wolfgang A., Vaginal delivery of bisphosphonates.
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Wong Patrick S. (Kowloon HKX), Vaginal drug delivery system made from polymer.
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Villanueva,Julie M., Vaginal health products.
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Villanueva,Julie M.; Malik,Sohail, Vaginal health products.
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Myhling John (Rhinebeck NY), Vaginal sponge delivery system.
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Igo Stephen R. ; Meador James W., Vascular treatment method and apparatus.
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Spijkers, Jozef C. W.; Van De Ven, Hendricus J. M.; Mezger, Thomas; Bontinck, Dirk; De Koninck, Luc, Water vapor permeable thermoplastic polyurethane film.
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이 특허를 인용한 특허 (19) 인용/피인용 타임라인 분석

Tuominen, Jukka; Zurutuza, Amaia; Livingstone, Mark Alexander; Halliday, Janet Anne, Hydrophilic polyurethane compositions.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Cacace, Janice Louise; Persicaner, Peter H. R.; Irani, Neda; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Persicaner, Peter H. R.; Amadio, Julia M., Natural combination hormone replacement formulations and therapies.
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Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Cacace, Janice Louise; Thorsteinsson, Thorsteinn; Sancilio, Frederick D., Progesterone formulations.
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Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Irani, Neda; Cacace, Janice Louise; Thorsteinsson, Thorsteinn; Sancilio, Frederick D., Soluble estradiol capsule for vaginal insertion.
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Shadiack, Annette; Persicaner, Peter H. R.; Inskeep, Philip B.; Thorsteinsson, Thorsteinn; Sancilio, Frederick D.; Legassie, Jason D., Steroid hormone pharmaceutical composition.
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Bernick, Brian A.; Amadio, Julia M.; Persicaner, Peter H. R.; Cacace, Janice Louise; Irani, Neda; Sancilio, Frederick D., Transdermal hormone replacement therapies.
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Bernick, Brian A.; Amadio, Julia M., Vaginal inserted estradiol pharmaceutical compositions and methods.
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Mirkin, Sebastian; Amadio, Julia M.; Bernick, Brian A., Vaginal inserted estradiol pharmaceutical compositions and methods.
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Halliday, Janet Anne; Tuominen, Jukka; Livingstone, Mark Alexander; Koppenhagen, Frank; Currie, Lilias Morton; Stewart, Sarah, Water-swellable polymers.
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해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Water-swellable polymers 원문보기

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[미국특허] Water-swellable polymers 원문보기

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