초록

The invention relates to scaffolds for artificial heart valves and vascular structures comprising a biocompatible block copolymer. A method and means for producing said scaffold are also provided.

대표청구항 ▼

1. Scaffold comprising an electro-spun mesh of a biocompatible block-copolymer, wherein said scaffold has about 90% open pores and a mesh-like structure formed by polymer fibers of about 5 to 10 μm diameter, and wherein said block copolymer has at least two block units obtainable by linear polyconde

1. Scaffold comprising an electro-spun mesh of a biocompatible block-copolymer, wherein said scaffold has about 90% open pores and a mesh-like structure formed by polymer fibers of about 5 to 10 μm diameter, and wherein said block copolymer has at least two block units obtainable by linear polycondensation in the presence of diisocyanate, diacid halide or phosgene of first block unit selected from the group consisting of a diol (I) and an α,ω-dihydroxy-polyester (IV) with a second block unit selected from the group consisting of the same diol (I), an α,ω-dihydroxy-polyester (II), an α,ω-dihydroxy-polyether (III), and the same α,ω-dihydroxy-polyester (IV),wherein the diol (I) is obtainable by transesterification of poly-[(R)-(3)-hydroxybutyric acid] or copolymers thereof with 3-hydroxyvaleric acid with ethylene glycol,wherein the α,ω-dihydroxy-polyester (II) is obtainable by ring-opening polymerization of cyclic esters selected from the group consisting of (L,L)-dilactide, (D,D)-dilactide, (D,L)-dilactide, diglycolide or mixtures thereof, or lactones selected from the group consisting of β-(R)-butyrolactone, β-(S)-butyrolactone, β-rac-butyrolactone and ε-caprolactone or mixtures thereof,wherein the α,ω-dihydroxy-polyether (III) is selected from the group consisting of α,ω-dihydroxy-poly(oxytetramethylene), α,ω-dihydroxy-poly(oxyethylene) and copolymers of ethylene glycol and propylene glycol,wherein the α,ω-dihydroxy-polyester (IV) is obtainable by trans-esterification of the diol (I) with diglycolide and/or dilactide and/or caprolactone or mixtures thereof. 2. Scaffold according to claim 1, wherein the first block unit is the α,ω-dihydroxy-polyester (IV) and the second block unit is the diol (I). 3. Scaffold according to claim 1, wherein the first block unit is the α,ω-dihydroxy-polyester (IV) and the second block unit is the α,ω-dihydroxy-polyester (II). 4. Scaffold according to claim 1, wherein the first block unit is the α,ω-dihydroxy-polyester (IV) and the second block unit is the α,ω-dihydroxy-polyether (III). 5. Scaffold according to claim 1, wherein the first block unit is the α,ω-dihydroxy-polyester (IV) and the second block unit is the same α,ω-dihydroxy-polyester (IV). 6. Scaffold according to claim 1, wherein the scaffold is made of said block copolymer. 7. Scaffold according to claim 1, wherein cells are cultured on said scaffold. 8. Scaffold according to claim 1, wherein the scaffold has a tubular form. 9. Scaffold according to claim 1, wherein the scaffold has a form of a vessel. 10. Scaffold according to claim 1, wherein the scaffold has a form of a heart valve. 11. Scaffold according to claim 1, wherein the scaffold is hydrolytically degradable and has a controllable service life time and keeps its performance from 5 days up to 2 years. 12. Scaffold according to claim 7, wherein said cells are selected from the group consisting of endothelial cells and myofibroblasts. 13. Scaffold according to claim 9, wherein said scaffold has a form of a blood vessel. 14. Method for producing the scaffold for tissue engineering according to claim 1, comprising the steps a) manufacturing a suitably formed carrier structure;b) disposing the biocompatible block-copolymer as the mesh-like structure on said carrier structure by electro-spinning; andc) removing the carrier structure from the scaffold. 15. Method according to claim 14, wherein the carrier structure is cooled by cooling means. 16. Method according to claim 15, wherein the cooling means are cold gases, preferably nitrogen or CO2. 17. Method according to claim 14, wherein the carrier structure has a tubular form. 18. Method according to claim 14, wherein the carrier structure has a form of a vessel. 19. Method according to claim 14, wherein the carrier structure has a form of a heart valve.