IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0797816
(2010-06-10)
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등록번호 |
US-8571620
(2013-10-29)
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발명자
/ 주소 |
- Cinbis, Can
- Carney, James K.
- Kuhn, Jonathan L.
- Anderson, David A.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
77 |
초록
▼
A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery modul
A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
대표청구항
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1. A medical device for monitoring delivery of a therapy, comprising: a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient;a therapy delivery module to deliver the therapy; anda processor configured to compute a first tissue oxygenation
1. A medical device for monitoring delivery of a therapy, comprising: a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient;a therapy delivery module to deliver the therapy; anda processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement, wherein the processor determines whether the delivered therapy was successful in response to the second tissue oxygenation measurement being greater than the first tissue oxygenation measurement. 2. The device of claim 1, wherein the processor is further configured to adjust a parameter controlling delivery of the therapy in response to the second tissue oxygenation measurement being not greater than the first tissue oxygenation measurement, compute a tissue oxygenation measurement from the sensor signal for the adjusted parameter, and continue to adjust the parameter and compute the tissue oxygenation measurement until a parameter setting resulting in a tissue oxygenation measurement that is greater than the first tissue oxygenation measurement is identified and determine whether the delivered therapy was successful in response to the identified parameter setting. 3. The device of claim 1, wherein the processor is further configured to adjust a parameter controlling delivery of the therapy to a plurality of settings, compute a tissue oxygenation measurement for each of the plurality of settings, determine a setting for the parameter corresponding to a maximum tissue oxygenation, and deliver the therapy using the determined parameter setting. 4. The device of claim 3, further comprising an activity sensor to sense an activity sensor signal corresponding to activity of the patient, wherein the processor is further configured to sense detect a change in activity level of the patient from the activity sensor signal, compute a tissue oxygenation measurement in response to detecting the change in activity level, detect a decrease in tissue oxygenation in response to the tissue oxygenation measurement computed in response to detecting the change in activity level, and adjust a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation. 5. The device of claim 1, wherein computing the first tissue oxygenation measurement and the second tissue oxygenation measurement comprises computing a second derivative of light attenuation with respect to wavelength and computing a tissue oxygen saturation using the second derivative. 6. The device of claim 5, wherein computing the first tissue oxygenation measurement and the second tissue oxygenation measurement further comprises computing a total hemoglobin volume fraction using the tissue oxygen saturation. 7. The device of claim 5, wherein computing the first tissue oxygenation measurement and the second tissue oxygenation measurement further comprises computing a tissue oxygenation index as a function of the tissue oxygen saturation and the total hemoglobin volume fraction. 8. A method for monitoring delivery of a therapy in a medical device, comprising; sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient;initiating delivery of the therapy;computing a first tissue oxygenation measurement from the optical sensor signal prior to initiating deliver of the therapy;computing a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy;comparing the first and the second tissue oxygenation measurements; anddetermining whether the therapy was successful in response to the second tissue oxygenation measurement being greater than the first tissue oxygenation measurement. 9. The method of claim 8, further comprising: adjusting a parameter controlling delivery of the therapy in response to the second tissue oxygenation measurement not being greater than the first tissue oxygenation measurement;computing a tissue oxygenation measurement from the optical sensor signal for the adjusted parameter; andcontinuing to adjust the parameter and compute the tissue oxygenation measurement until a parameter setting resulting in a tissue oxygenation measurement that is greater than the first tissue oxygenation measurement is identified and determining that the therapy was successful in response to the identified parameter setting. 10. The method of claim 8, further comprising: adjusting a parameter controlling delivery of the therapy to a plurality of settings;computing a tissue oxygenation measurement for each of the plurality of settings;determining a setting for the parameter corresponding to a maximum tissue oxygenation; anddelivering the therapy using the determined parameter setting. 11. The method of claim 10, further comprising: sensing an activity sensor signal;detecting a change in activity level of the patient from the activity sensor signal;computing a tissue oxygenation measurement in response to detecting the change in activity level;detecting a decrease in tissue oxygenation in response to the tissue oxygenation measurement computed in response to detecting the change in activity level; andadjusting a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation. 12. The method of claim 10, wherein computing the tissue oxygenation measurement comprises computing a second derivative of light attenuation with respect to wavelength and computing a tissue oxygen saturation in response to the second derivative. 13. The method of claim 12, wherein computing the tissue oxygenation measurement comprises computing a total hemoglobin volume fraction in response to the tissue oxygen saturation. 14. The method of claim 13, wherein computing the tissue oxygenation measurement comprises computing a tissue oxygenation index as a function of the tissue oxygen saturation and the total hemoglobin volume fraction. 15. A non-transitory computer readable medium having computer executable instructions for performing a method comprising: sensing an activity sensor signal;detecting a change in activity level of the patient from the activity sensor signal;computing a first tissue oxygenation measurement in response to detecting the change in activity level;computing a second tissue oxygenation measurement in response to detecting the change in activity level;detecting a decrease in tissue oxygenation in response to the first tissue oxygenation measurement computed in response to detecting the change in activity level;adjusting a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation;comparing the first tissue oxygenation measurement to the second tissue oxygenation measurement; anddetermining whether the therapy was successful in response to the second tissue oxygenation measurement being greater than the first tissue oxygenation measurement. 16. The computer readable medium of claim 15, wherein the method further comprises: adjusting a parameter controlling delivery of the therapy in response to the second tissue oxygenation measurement not being greater than the first tissue oxygenation measurement;computing a tissue oxygenation measurement from the optical sensor signal for the adjusted parameter; andcontinuing to adjust the parameter and compute the tissue oxygenation measurement until a parameter setting resulting in a tissue oxygenation measurement that is greater than the first tissue oxygenation measurement is identified and determining that the therapy was successful in response to the identified parameter setting. 17. The computer readable medium of claim 15, wherein the method further comprises: adjusting a parameter controlling delivery of the therapy to a plurality of settings;computing a tissue oxygenation measurement for each of the plurality of settings;determining a setting for the parameter corresponding to a maximum tissue oxygenation; anddelivering the therapy using the determined parameter setting. 18. The computer readable medium of claim 17, wherein the method further comprises: sensing an activity sensor signal;detecting a change in activity level of the patient from the activity sensor signal;computing a tissue oxygenation measurement in response to detecting the change in activity level;detecting a decrease in tissue oxygenation in response to the tissue oxygenation measurement computed in response to detecting the change in activity level; andadjusting a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation. 19. The computer readable medium of claim 17, wherein computing the tissue oxygenation measurement comprises computing a second derivative of light attenuation with respect to wavelength and computing a tissue oxygen saturation in response to the second derivative. 20. The computer readable medium of claim 19, wherein computing the tissue oxygenation measurement comprises computing a total hemoglobin volume fraction in response to the tissue oxygen saturation. 21. The computer readable medium of claim 20, wherein computing the tissue oxygenation measurement comprises computing a tissue oxygenation index as a function of the tissue oxygen saturation and the total hemoglobin volume fraction.
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