System and methods for processing analyte sensor data for sensor calibration
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/05
출원번호
US-0683724
(2010-01-07)
등록번호
US-8579816
(2013-11-12)
발명자
/ 주소
Kamath, Apurv Ullas
Goode, Paul V.
Brauker, James H.
출원인 / 주소
DexCom, Inc.
대리인 / 주소
Knobbe, Martens, Olson & Bear LLP
인용정보
피인용 횟수 :
14인용 특허 :
312
초록▼
Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set
Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
대표청구항▼
1. A method for calibrating a continuous glucose sensor, comprising: receiving sensor data from a continuous glucose sensor, wherein the sensor data is indicative of a glucose concentration in a host, wherein a predictive relationship exists between in vitro sensitivity and in vivo sensitivity repre
1. A method for calibrating a continuous glucose sensor, comprising: receiving sensor data from a continuous glucose sensor, wherein the sensor data is indicative of a glucose concentration in a host, wherein a predictive relationship exists between in vitro sensitivity and in vivo sensitivity represented by min vivo≈f(min vitro), wherein min vivo is the in vivo sensitivity after inserting the continuous glucose sensor in the host, min vitro is the in vitro sensitivity prior to inserting the continuous glucose sensor in the host, and f is the predictive relationship between min vitro and min vivo;receiving a priori sensitivity information associated with the continuous glucose sensor; andcalibrating, using a processor module, the continuous glucose sensor based on the a priori sensitivity information, wherein the calibrating is performed without reliance on reference glucose values obtained from an in vitro self-monitoring blood glucose test after insertion of the glucose sensor in vivo. 2. The method of claim 1, wherein the a priori sensitivity information comprises the min vitro. 3. The method of claim 2, wherein the min vitro is derived from an analysis of sensor sensitivities collected from a representative set of sensors. 4. The method of claim 1, wherein the a priori sensitivity information comprises the predictive relationship, f. 5. The method of claim 4, wherein the predictive relationship is determined based on a retrospective analysis of sensor sensitivities collected from a representative set of sensors. 6. The method of claim 1, wherein the receiving the a priori sensitivity information is from a calibration code associated with the continuous glucose sensor. 7. The method of claim 6, wherein the calibration code is provided on a housing that supports the continuous glucose sensor. 8. The method of claim 1, further comprising measuring a change in sensitivity and/or baseline based on one or more signals obtained from electrodes of the continuous glucose sensor. 9. The method of claim 8, further comprising calibrating based on the measured change in sensitivity and/or baseline. 10. A system for calibrating a continuous glucose sensor, comprising: a continuous glucose sensor configured to provide sensor data indicative of a glucose concentration in a host, wherein a predictive relationship exists between in vitro sensitivity and in vivo sensitivity represented by min vivo≈f(min vitro), wherein min vivo is the in vivo sensitivity after inserting the continuous glucose sensor in the host, min vitro is the in vitro sensitivity prior to inserting the continuous glucose sensor in the host, and f is the predictive relationship between min vitro and min vivo; anda processor module configured receive a priori sensitivity information associated with the continuous glucose sensor and calibrate the continuous glucose sensor based on the a priori sensitivity information, wherein the processor module is configured to calibrate the continuous glucose sensor without reliance on reference glucose values obtained from an in vitro self-monitoring blood glucose test after insertion of the glucose sensor in vivo. 11. The system of claim 10, wherein the a priori sensitivity information comprises the min vitro. 12. The system of claim 11, wherein the min vitro is derived from an analysis of sensor sensitivities collected from a representative set of sensors. 13. The system of claim 10, wherein the a priori sensitivity information comprises the predictive relationship, f. 14. The system of claim 13, wherein the predictive relationship is determined based on a retrospective analysis of sensor sensitivities collected from a representative set of sensors. 15. The system of claim 10, wherein the processor module is configured to receive the a priori sensitivity information from a calibration code associated with the continuous glucose sensor. 16. The system of claim 15, wherein the calibration code is provided on a housing that supports the continuous glucose sensor. 17. The system of claim 10, wherein the processor module is configured to measure a change in sensitivity and/or baseline based on one or more signals obtained from electrodes of the continuous glucose sensor. 18. The system of claim 17, wherein the calibrating is further based on the measured change in sensitivity and/or baseline. 19. The system of claim 10, further comprising: a transmitter unit operably coupled to the glucose sensor, the transmitter unit having a radio frequency transmitter configured to wirelessly transmit sensor data; anda receiver unit comprising a radio frequency receiver and a display, the radio frequency receiver configured to receive the transmitted sensor data and the display configured to display information based on the transmitted sensor data. 20. The system of claim 19, wherein the processor module is incorporated in the transmitter unit and the transmitted sensor data is calibrated sensor data.
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이 특허에 인용된 특허 (312)
Allen Douglas J. (Indianapolis IN) Nevin Robert S. (Indianapolis IN), Acrylic copolymer membranes for biosensors.
Lebel, Ronald J.; Shahmirian, Varaz; Starkweather, Timothy J.; Weiss, Philip T.; Villegas, Daniel H.; Dennard, Robert C.; Armstrong, John T.; Richert, John D., Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S. ; Friedman Keith A. ; Colman Fredric C., Analyte monitoring device and methods of use.
Causey ; III James D. ; Kovelman Paul H. ; Purvis Richard E. ; Mastrototaro John J., Analyte sensor and holter-type monitor system and method of using the same.
Bcker Dirk (Heidelberg DEX) Haar Hans-Peter (Wiesloch DEX) Blasberg Peter (Weinheim DEX) Kotulla Reinhard (Lambsheim DEX), Analytical system for monitoring a substance to be analyzed in patient-blood.
White Bradley E. (Indianapolis IN) Parks Robert A. (Springport IN) Ritchie Paul G. (Indianapolis IN) Svetnik Vladimir (Carmel IN), Biosensing meter with fail/safe procedures to prevent erroneous indications.
Simons Tad Decatur ; Greenstein Michael ; Freeman Dominique ; Leonard Leslie Anne ; King David A. ; Lum Paul, Cassette of lancet cartridges for sampling blood.
Steil, Garry M.; Rebrin, Kerstin; Goode, Jr., Paul V.; Mastrototaro, John J.; Purvis, Richard E.; Van Antwerp, William P.; Shin, John J.; Talbot, Cary D., Closed loop system for controlling insulin infusion.
Gough David A. (Cardiff CA) Lucisano Joseph Y. (La Jolla CA) Armour Jon C. (La Jolla CA) McKean Brian D. (San Diego CA), Complete glucose monitoring system with an implantable, telemetered sensor module.
Routh Helen F. (Kirkland WA) Powrie ; Jr. Charles W. (Bellevue WA) Peterson Roy B. (Redmond WA), Continuous display of peak and mean blood flow velocities.
Ham Fredric M. (Indialantic FL) Cohen Glenn M. (Indialantic FL), Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discrimi.
Gross Joseph,ILX ; Reingewirtz Meir,ILX ; Katz Moshe George,ILX, Device and method of calibrating and testing a sensor for in vivo measurement of an analyte.
Bret Berner ; Chia-Ming Chiang ; Michael D. Garrison ; Janan Jona ; Russell O. Potts ; Janet A. Tamada ; Michael J. Tierney, Device for monitoring of physiological analytes.
Berner, Bret; Dunn, Timothy C.; Farinas, Kathleen C.; Garrison, Michael D.; Kurnik, Ronald T.; Lesho, Matthew J.; Potts, Russell O.; Tamada, Janet A.; Tierney, Michael J., Device for signal processing for measurement of physiological analytes.
Conn, Thomas E.; Ford, Russell; Potts, Russell O.; Soni, Pravin L.; Tamada, Janet A.; Tierney, Michael J., Devices and methods for frequent measurement of an analyte present in a biological system.
James Say ; Michael F. Tomasco ; Adam Heller ; Yoram Gal IL; Behrad Aria ; Ephraim Heller ; Phillip John Plante ; Mark S. Vreeke, Electrochemical analyte sensor.
Maley Thomas C. (Medway MA) D\Orazio Paul A. (Mendon MA) Dalzell Bonnie C. (Sherborn MA) Edelman Peter G. (Franklin MA) Flaherty James E. (Attleboro MA) Mason Richard W. (Millis MA) McCaffrey Robert , Electrochemical sensors.
Stafford Rodney A. (Ballyross Glencree ; County Wicklow IEX) Kilroy Michael M. (Castlecor Oldcastle ; County Meath IEX), Electronic animal identification system.
D\Orazio Paul A. (Mishawaka IN) Eddy ; Jr. Arthur R. (Depew NY) Fogt Eric J. (Maple Grove MN) Jones James E. (Elkhart IN) Oberhardt Bruce J. (Mishawaka IN), Enzyme electrode membrane.
Gregg Brian A. (13940 Braun Dr. Golden CO 80401) Heller Adam (5317 Valburn Cir. Austin TX 78731) Kerner Wolfgang (Universitat Zu Lubeck ; Klinik Fur Innerere Medizin ; Razeburger Allee 160 D-2400 Lub, Enzyme electrodes.
Lord Peter C. (Santa Clarita CA) Van Antwerp William P. (Brentwood CA) Mastrototaro John J. (Los Angeles CA) Cheney ; II Paul S. (Beverly Hills CA) Schnabel Nannette M. (Valencia CA), Flex circuit connector.
Schulman Joseph H. (10650 Comet Way Santa Clarita CA 91351) Rule ; III Orville R. (2572 Basil La. Los Angeles CA 90077), Fluidic infusion system for catheter or probe.
Ford, Russell; Lesho, Matthew J.; Potts, Russell O.; Tierney, Michael J.; Wei, Charles W., Formulation and manipulation of databases of analyte and associated values.
Francis Moussy ; Robert W. Conlan ; Markham C. Godwin ; Richard D. Beach, Generic integrated implantable potentiostat telemetry unit for electrochemical sensors.
Young Chung C. (Weston MA) Gary Kenneth (Belmont MA) Winarta Handani (Waltham MA) Chen Chin-Chun (Wayland MA), Glucose electrode and method of determining glucose.
Schulman Joseph H. (Santa Clarita CA) Rule ; III Orville R. (Los Angeles CA) Whitmoyer David I. (Los Angeles CA) Lebel Ronald J. (Sherman Oaks CA) Lucisano Joseph Y. (Saugus CA) Mann Alfred E. (Bever, Glucose monitoring system.
Schulman Joseph H. (Santa Clarita CA) Rule ; III Orville Rey (Los Angeles CA) Whitmoyer David I. (Los Angeles CA) Lebel Ronald J. (Sherman Oaks CA) Lucisano Joseph Y. (Saugus CA) Mann Alfred E. (Beve, Glucose sensor assembly.
Allen Douglas J. (Indianapolis IN) Johnson Kirk W. (Indianapolis IN) Nevin Robert S. (Indianapolis IN), Hydrophilic polyurethane membranes for electrochemical glucose sensors.
Dionne Keith E. ; Emerich Dwaine F. ; Hoffman Diane ; Sanberg Paul R. ; Christenson Lisa ; Hegre Orion D. ; Scharp David W. ; Lacy Paul E. ; Aebischer Patrick,CHX ; Vasconcellos Alfred V. ; Lysaght M, Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products.
Joseph H. Schulman ; Charles L. Byers ; Gerald E. Adomian ; Michael S. Colvin, Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces.
Bessman Samuel P. (2025 Zonal Ave. Los Angeles CA 90033) Layne Ennis C. (9128 Huntington Dr. San Gabriel CA 91775) Thomas Lyell J. (1900 Pelican Ave. San Pedro CA 90732), Implantable glucose sensor.
Wilson George S. (Lawrence KS) Bindra Dilbir S. (Lawrence KS) Hill Brian S. (Lawrence KS) Thevenot Daniel R. (Paris Cedex FRX) Sternberg Robert (Thiais FRX) Reach Gerard (Paris Cedex KS FRX) Zhang Ya, Implantable glucose sensor.
Kimball Victor E. ; Lynch Laurie E. ; Pierskalla Irvin T. ; Porter Christopher H., In situ calibration system for sensors located in a physiologic line.
Brauker, James H.; Tapsak, Mark A.; Saint, Sean T.; Kamath, Apurv U.; Neale, Paul V.; Simpson, Peter C.; Mensinger, Michael Robert; Markovic, Dubravka, Integrated delivery device for continuous glucose sensor.
D\Angelo Joseph P. (Miami FL) Schur Henry B. (Miami FL) Han Kedu (Miami FL) Glenn Daniel J. (Hollywood FL), Integrated system for biological fluid constituent analysis.
Erickson Brian J. (Woodbury MN) Hilgers Michael E. (Roseville MN) Hendrickson Tracy A. (Minnetonka MN) Shapland J. Edward (Shoreview MN) Solomon Frank A. (Plymouth MN) Knudson Mark B. (Shoreview MN), Interstitial fluid collection and constituent measurement.
Say, James L.; Sakslund, Henning; Tomasco, Michael F.; Audett, Jay D.; Cho, Hyun; Yamasaki, Duane O.; Heller, Adam, Mass transport limited in vivo analyte sensor.
Houck Raymond K. ; Koebler Douglas J. ; Williams Glen P. ; Levy Joseph M. ; Danielson Victor G., Method and apparatus for determination of analyte concentration.
Reinhart Richard (Lawrenceville NJ) Letterio Fred (Philadelphia PA) Pugliese Peter (Bernville PA) Ritter Carl (Aldan PA) Lubrano Glenn (Metairie LA) Guilbault Jerry (Slidell LA) Feistel Christopher (, Method and apparatus for measuring blood glucose concentration.
Pizziconi Vincent B. (3535 E. Highline Canal Rd. Phoenix AZ 85040) Towe Bruce C. (2331 S. Paseo Loma Cir. Mesa AZ 85202), Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids.
Monfre,Stephen L.; Hazen,Kevin H.; Ruchti,Timothy L.; Blank,Thomas B.; Henderson,James R., Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers.
Dunn, Timothy C.; Jayalakshmi, Yalia; Kurnik, Ronald T.; Lesho, Matthew J.; Oliver, Jonathan James; Potts, Russell O.; Tamada, Janet A.; Waterhouse, Steven Richard; Wei, Charles W., Method and device for predicting physiological values.
Kurnik Ronald T. ; Oliver Jonathan James ; Potts Russell O. ; Waterhouse Steven Richard ; Dunn Timothy C. ; Jayalakshmi Yalia ; Lesho Matthew J. ; Tamada Janet A. ; Wei Charles W., Method and device for predicting physiological values.
Luong John H. T. (Mount Royal CAX) Male Keith B. (Pierrfonds CAX) Cattaneo Maurice V. (Outremont CAX), Method and system for determining bioactive substances.
Yacynych Alexander (2 Bernard Rd. East Brunswick NJ 08816), Method for making electrochemical sensors and biosensors having a polymer modified surface.
Richardson Charles A. (San Francisco CA) Bernstein Michael (San Ramon CA) Okikawa Jerry K. (Oakland CA) Bennett Terrence R. (Richmond CA), Method for reducing ambient noise effects in electronic monitoring instruments.
Genshaw Marvin A. (Elkhart IN) Huang Dijia (Granger IN) Musho Matthew K. (Granger IN) Yip Kin Fai (Elkhart IN), Method for reducing bias in amperometric sensors.
Khalil, Omar S.; Yeh, Shu-jen; Hanna, Charles F.; Kantor, Stanislaw, Method for the non-invasive determination of analytes in a selected volume of tissue.
Desai,Shashi P.; Dunn,Timothy C.; Lesho,Matthew J.; Potts,Russell O.; Tamada,Janet A.; Wei,Charles W., Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods.
Dunn Timothy C. ; Jayalakshmi Yalia ; Kurnik Ronald T. ; Lesho Matthew J. ; Oliver Jonathan James ; Potts Russell O. ; Tamada Janet A. ; Waterhouse Steven Richard ; Wei Charles W., Microprocessors for use in a device for predicting physiological values.
Berner Bret ; Chiang Chia-Ming ; Garrison Michael D. ; Jona Janan ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Monitoring of physiological analytes.
Tarr Randall V. (Atlanta GA) Steffes Paul G. (Norcross GA), Non-invasive blood glucose measurement system and method using stimulated Raman spectroscopy.
Sodickson Lester (P.O. Box 148 Waban MA) Block Myron J. (P.O. Box 148 North Salem NH 03073), Non-spectrophotometric measurement of analyte concentrations and optical properties of objects.
Oka Tohru,JPX ; Takakura Makoto,JPX, Physical information monitor system having means for determining reference range for abnormality determination, based.
Clark ; Jr. Leland (Cincinnati OH), Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sens.
Swette Larry L. ; Griffith Arthur E. ; LaConti Anthony B., Potential and diffusion controlled solid electrolyte sensor for continuous measurement of very low levels of transdermal.
Fidler John C. (DeKalb) Bobis James P. (Downers Grove) Penrose William R. (Naperville) Stetter Joseph R. (Naperville IL), Potentiostatic apparatus and methods.
Shin, John J.; Holtzclaw, Kris R.; Dangui, Nandita D.; Kanderian, Jr., Sami; Mastrototaro, John J.; Hong, Peter I., Real time self-adjusting calibration algorithm.
Berner Bret ; Dunn Timothy C. ; Farinas Kathleen C. ; Garrison Michael D. ; Kurnik Ronald T. ; Lesho Matthew J. ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Signal processing for measurement of physiological analysis.
Alvarez Khristopher Edward ; Berry Paul Anthony ; Stanga Michael Allen ; Strong Michael Raymond, Silicone gel composition and silicone gel produced therefrom.
Benjamin J. Feldman ; Adam Heller ; Ephraim Heller ; Fei Mao ; Joseph A. Vivolo ; Jeffery V. Funderburk ; Fredric C. Colman ; Rajesh Krishnan, Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator.
Hill Hugh Allen Oliver (Oxford GB3) Higgins Irving John (Bedford GB3) McCann James Michael (Oxford GB3) Davis Graham (Plainsborough NJ), Strip electrode with screen printing.
Keith,Steven; Parker,Robert S.; Harvey,Noel G.; Pettis,Ronald J.; DeNuzzio,John D.; Vonk,Glenn, System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or .
Mann, Alfred E.; Purvis, Richard E.; Mastrototaro, John J.; Causey, James D.; Henke, James; Hong, Peter; Livingston, John H.; Hague, Clifford W.; Hite, Brad T., Telemetered characteristic monitor system and method of using the same.
Grill ; Jr. Warren M. (Cleveland Hts. OH) Creasey Graham H. (Cleveland Hts. OH) Ksienski David A. (Hermosa Beach CA) Veraart Claude S. (Brussels OH BEX) Mortimer J. Thomas (Chagrin Falls OH), Thin film implantable electrode and method of manufacture.
Cheney ; II Paul S. (Beverly Hills CA) Mastrototaro John J. (Los Angeles CA) Schnabel Nannette M. (Valencia CA) Lord Peter C. (Valencia CA) Van Antwerp William P. (Los Angeles CA) Clark Raymond D. (V, Transcutaneous sensor insertion set.
Lord Peter C. (Santa Clarita CA) Van Antwerp William P. (Brentwood CA) Mastrototaro John J. (Los Angeles CA) Cheney ; II Paul S. (Beverly Hills CA) Schnabel Nannette M. (Valencia CA), Transcutaneous sensor insertion set.
Band David M. (88 Ditton Road ; Surbiton Surrey GBX) Penman David G. (No. 1 Brief Street ; Myatts Field London UT GBX) Kratochvil Jiri (3551 S. Canyon Way Salt Lake City UT), pH electrode.
Schweitzer, Nimrod; Yosef, Andrei; Eitan, Boaz; Eitan, Shaul; Ofer, Meged; Sayag, Shalom, Methods, circuits, devices, apparatuses, encasements and systems for identifying if a medical infusion system is decalibrated.
Pryor, Jack; Kamath, Apurv Ullas; Goode, Jr., Paul V.; Brauker, James H., System and methods for processing analyte sensor data for sensor calibration.
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