Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship bet
Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced.
대표청구항▼
1. A microneedle device comprising: a concave part,a flat plate fixing member for fixing a microneedle, anda supporting member at or near a periphery of the flat plate fixing member,whereinthe supporting member has an opening for forming the concave part,the flat plate fixing member constitutes a bo
1. A microneedle device comprising: a concave part,a flat plate fixing member for fixing a microneedle, anda supporting member at or near a periphery of the flat plate fixing member,whereinthe supporting member has an opening for forming the concave part,the flat plate fixing member constitutes a bottom part of the microneedle device and is a hard member configured to transmit pressure from a finger to skin to thereby elevate the skin surface inside the concave part and to prevent the axial direction of small needles of the microneedle from being shifted,the supporting member comprises a resin, andthe microneedle is placed in a central part of the concave part such that:(a) tip portions of small needles of the microneedle are positioned inside the microneedle device from a tip surface of the supporting member, and(b) a distance between the tip portions of the small needles and the tip surface plane of the supporting member is 15% or shorter than the inner dimension of the opening. 2. The microneedle device according to claim 1, wherein the inner dimension of the opening of the supporting member is 5 to 70 mm. 3. The microneedle device according to claim 2, wherein the inner dimension of the opening of the supporting member is 5 to 50 mm. 4. The microneedle device according to claim 3, wherein the shape of the opening of the supporting member is a circular shape. 5. The microneedle device according to claim 4, wherein the circular shape has a diameter of 5 to 32 mm. 6. The microneedle device according to claim 3, wherein the shape of the opening of the supporting member is an elliptical shape. 7. The microneedle device according to claim 3, wherein the shape of the opening of the supporting member is a polygonal shape. 8. The microneedle device according to claim 7, wherein the polygonal shape is a square shape. 9. The microneedle device according to claim 1, wherein the shape of the opening of the supporting member is a circular shape, an elliptical shape, or a polygonal shape. 10. The microneedle device according to claim 9, wherein the polygonal shape is a square shape. 11. The microneedle device according to claim 9, wherein the circular shape has a diameter of 5 to 32 mm. 12. The microneedle device according to claim 1, wherein the shape of the opening of the supporting member is a rectangular shape, and the inner dimension is an average of a long side and a short side of the rectangular shape. 13. The microneedle device according to claim 1, wherein the flat plate fixing member comprises a synthetic resin selected from polyethylene, polypropylene, polyvinyl chloride, acrylic, polyethylene terephthalate, polystyrene, acrylonitrile-butadiene-styrene copolymer, polycarbonate, polyamide, fluororesin, and polybutylene-terephthalate. 14. The microneedle device according to claim 1, wherein the resin of the supporting member is selected from polyethylene, polypropylene, polyvinyl chloride, acrylic, polyethylene terephthalate, polystyrene, acrylonitrile-butadiene-styrene copolymer, polycarbonate, polyamide, fluororesin, and polybutylene-terephthalate. 15. The microneedle device according to claim 1, wherein the flat plate fixing member and the supporting member comprise polypropylene.
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이 특허에 인용된 특허 (1)
Cantor, Adam S.; Frederickson, Franklyn L.; Johnson, Peter R.; Ringsred, Ted K., Low-profile microneedle array applicator.
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