[특허]Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue

[미국특허] Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-031/00
출원번호	US-0383147 (2010-08-16)
등록번호	US-8597262 (2013-12-03)
국제출원번호	PCT/US2010/041525 (2010-08-16)
§371/§102 date	20120229 (20120229)
국제공개번호	WO2011/006067 (2011-01-13)
발명자 / 주소	Canifax, Rosa K. Dinh, Thomas Q. Koullick, Edouard A. Bouchier, Mark S.
출원인 / 주소	AMS Research Corporation
대리인 / 주소	Kagan Binder, PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 41

초록 ▼

A uterine fibroid treatment device providing for localized delivery of one or more treatment drugs for treating various uterine conditions including, for example, uterine fibroids, abnormal uterine bleeding, pelvic adhesions and endometriosis. Generally, the uterine treatment device comprises a physical positioning element that can be inserted, positioned and maintained in close proximity to the uterine tissue to be treated. The treatment drugs delivered to the treatment location can include various combinations of anti-proliferative agents and angiogenesis inhibitors to provide different treatments concurrently. In some embodiments, the physical element can also serve the dual purpose of delivering the treatment drugs while simultaneously cutting off blood flow to a mature fibroid to initiate hypoxic/ischemic conditions within the mature fibroid.

대표청구항 ▼

1. A vaginally introduced implant configured for use in a woman and for treating pathologic proliferative conditions of uterine tissue comprising: a drug-eluting treatment element comprising at least one pathologic proliferative condition treatment drug, the treatment element positionable proximate to a location of uterine proliferative cells, wherein the drug-eluting treatment element is adapted to elute the treatment drug over an effective treatment period; anda retention element operably linked to the treatment element and positionable within a body cavity to maintain the treatment element proximate to the location of uterine proliferative cells. 2. The vaginally introduced implant of claim 1, wherein the retention element further comprises a body sized to engage at least two tissue walls of a body lumen proximate the uterine proliferative cells to maintain the treatment element proximate to the location of the uterine proliferative cells. 3. The vaginally introduced implant of claim 1, wherein the retention element further comprises a biological adhesive for adhering the retention element to a wall of a body lumen so as to maintain the treatment element proximate to the location of the uterine proliferative cells. 4. The vaginally introduced implant of claim 3, wherein the biological adhesive is biodegradable, wherein the biological adhesive is adapted to degrade over the effective treatment period to release the vaginally introduced implant at the end of the effective treatment period. 5. The vaginally introduced implant of claim 1, wherein the retention element further comprises: a plurality of approximating elements extendable from the retention element for engaging a tissue wall proximate the uterine proliferative cells;wherein the approximating elements are adjustable between a retracted position preventing the approximating elements from catching on tissue while positioning the treatment element and an extended position for engaging the tissue wall proximate the uterine proliferative cells. 6. The vaginally introduced implant of claim 1 wherein implant comprises a coating and the treatment drug is present in the coating. 7. The vaginally introduced implant of claim 6 wherein the treatment drug is coated over the entire implant. 8. The vaginally introduced implant claim 1, wherein the at least one treatment drug is selected from a group consisting of anti-proliferative agents, angiogenesis inhibitors or combinations thereof. 9. The vaginally introduced implant of claim 8 wherein the treatment drug comprises an anti-proliferative agent. 10. The vaginally introduced implant of claim 9 wherein the anti-proliferative agent is selected from the group consisting of rapamycin, podophyllotoxin, etoposide, troglitazone rosilitazone, curcumin, halofuginone, and 2-methoxyestradiol. 11. The vaginally introduced implant of claim 9 further comprising an angiogenesis inhibitor. 12. The vaginally introduced implant of claim 1, wherein the retention element further comprises: an anchor having: at least one retractable anchor arm positionable within a fallopian tube to maintain the treatment element proximate to the uterine proliferative cells and block the fallopian tube;wherein the treatment element comprises a stem operably linked to the at least one anchor arm;wherein the anchor arm is adjustable between a retracted position preventing the anchor arm from catching on tissue while positioning the treatment element proximate to the location of uterine proliferative cells and a extended position for anchoring the treatment element proximate to the location of uterine proliferative cells. 13. The vaginally introduced implant of claim 12 wherein the at least one anchor arm further comprises a spring for biasing the anchor arm to the extended position. 14. The vaginally introduced implant of claim 12, wherein the retractable arm comprises nickel titanium metal such that the retractable arm is movable between the extended and retracted position by applying different temperatures to the retractable arm. 15. The vaginally introduced implant of claim 12 wherein the stem comprises a coating and the treatment drug is present in the coating. 16. The vaginally introduced implant of claim 12, further comprising a ring operably linked to the stem and positionable within the vaginal cavity and adapted to elute the at least one treatment drag into the vaginal cavity over the effective treatment period. 17. The implant of claim 16, wherein at least a portion of the ring comprises a biodegradable material, wherein the biodegradable portion of the ring degrades gradually after the ring is positioned within the vaginal cavity to gradually administer the at least one treatment drug over the effective treatment period.

이 특허에 인용된 특허 (41) 인용/피인용 타임라인 분석

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Burbank, Fred; Altieri, Greig E.; Jones, Michael L., Methods for non-permanent occlusion of a uterine artery.
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[미국특허] Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue 원문보기