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[미국특허] Adjuvant therapy with an anti-ERBB2 antibody conjugated to a maytansiniod 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/395
출원번호 US-0205523 (2011-08-08)
등록번호 US-8597654 (2013-12-03)
발명자 / 주소
  • Bryant, John L.
출원인 / 주소
  • Genentech, Inc.
대리인 / 주소
    Pasqualone, Danielle
인용정보 피인용 횟수 : 5  인용 특허 : 84

초록

The present application describes adjuvant therapy of nonmetastatic breast cancer using an anti-ErbB2 antibody conjugated to a maytansinoid.

대표청구항 ▼

1. A method of adjuvant therapy comprising administering to a human subject having HER2 positive cancer, following definitive surgery, anthracycline cyclophosphamide (AC) based chemotherapy, followed by sequential administration of a taxoid and an effective amount of an immunoconjugate comprising an

이 특허에 인용된 특허 (84) 인용/피인용 타임라인 분석

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이 특허를 인용한 특허 (5) 인용/피인용 타임라인 분석

  1. Harris, Reed J.; Motchnik, Paul A., Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof.
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  2. Andya, James; Gwee, Shiang C.; Liu, Jun; Shen, Ye, Method of treating cancer with a pharmaceutical formulation comprising a HER2 antibody.
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  3. Gennaro, Lynn A.; Kao, Yung-Hsiang; Zhang, Yonghua, Pertuzumab variants and evaluation thereof.
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  4. Gennaro, Lynn A.; Kao, Yung-Hsiang; Zhang, Yonghua, Pertuzumab variants and evaluation thereof.
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  5. Amler, Lukas C.; Birkner, Merrill; Lin, Chin-Yu; Moecks, Joachim; Strauss, Andreas, Predicting response to a HER inhibitor.
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