Flavonoids as synergists for enhancing the action of self-tanning substances
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/73
A61Q-019/04
A61K-009/70
출원번호
US-0996846
(2006-05-10)
등록번호
US-8613910
(2013-12-24)
우선권정보
DE-10 2005 035 683 (2005-07-27)
국제출원번호
PCT/EP2006/004384
(2006-05-10)
§371/§102 date
20080125
(20080125)
국제공개번호
WO2007/012356
(2007-02-01)
발명자
/ 주소
Rudolph, Thomas
Buchholz, Herwig
Meduski, Jerzy
출원인 / 주소
Merck Patent GmbH
대리인 / 주소
Millen, White, Zelano, Branigan, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
4
초록▼
The invention relates to the use of at least one flavonoid having an uncharged flavan skeleton as synergist for enhancing the action of self-tanning substances, such as trioses and tetroses, in cosmetic and dermatological formulations and to corresponding novel compositions and to the preparation th
The invention relates to the use of at least one flavonoid having an uncharged flavan skeleton as synergist for enhancing the action of self-tanning substances, such as trioses and tetroses, in cosmetic and dermatological formulations and to corresponding novel compositions and to the preparation thereof.
대표청구항▼
1. A method for enhancing the action of a self-tanning substance in a cosmetic and/or dermatological formulation comprising including in said formulation a synergistically effective amount of at least one flavonoid having an uncharged flavan skeleton as synergist wherein said flavonoid is quercetin,
1. A method for enhancing the action of a self-tanning substance in a cosmetic and/or dermatological formulation comprising including in said formulation a synergistically effective amount of at least one flavonoid having an uncharged flavan skeleton as synergist wherein said flavonoid is quercetin, rutin, rutin sulfate, troxerutin and/or isoquercetinand wherein said self-tanning substance is dihydroxyacetone or 1,3,4-trihydroxy-2-butanone (erythrulose) and wherein the ratio of self-tanning substance to flavonoid is from 5:1 to 1:2. 2. A method according to claim 1, wherein the flavonoid is quercetin. 3. A method according to claim 1, wherein the flavonoid is rutin sulfate and/or troxerutin. 4. A method according to claim 1, wherein the self-tanning substance is dihydroxyacetone. 5. A method according to claim 1, wherein the self-tanning substance is 1,3,4-trihydroxy-2-butanone (erythrulose). 6. A method according to claim 1, wherein the cosmetic or dermatological formulation comprises at least one flavonoid in a total amount of 0.01 to 10% by weight. 7. A method according to claim 1, wherein the cosmetic or dermatological formulation comprises at least one substance which absorbs UV radiation in the UV-A and/or UV-B region. 8. A method according to claim 1, wherein the cosmetic or dermatological formulation comprises an inorganic pigment which serves as a UV filter substance. 9. A cosmetic and/or dermatological composition comprising a self-tanning substance and at least one flavonoid having an uncharged flavan skeleton and at least one active substance whose action is synergistically enhanced by the presence of the flavonoid wherein said flavonoid is quercetin, rutin, rutin sulfate, troxerutin and/or isoquercetin, andwherein said self-tanning substance is dihydroxyacetone or 1,3,4-trihydroxy-2-butanone (erythrulose) and wherein the ratio of self-tanning substance to flavonoid is from 5:1 to 1:2. 10. A composition according to claim 9, wherein the flavonoid is quercetin. 11. A composition according to claim 9, wherein the flavonoid is rutin, rutin sulfate, troxerutin or isoquercetin. 12. A composition according to claim 11, wherein the flavonoid is rutin sulfate and/or troxerutin. 13. A composition according to claim 9, wherein the cosmetic or dermatological formulation comprises at least one flavonoid in a total amount of 0.01 to 10% by weight. 14. A composition according to claim 9, further comprising a UV filter, flavone derivative, chromone derivative, aryl oxime or a paraben. 15. A composition according to claim 9, further comprising one or more antioxidant, vitamin, DL-a-tocopherol, tocopherol E acetate, nicotinic acid, pantothenic acid or biotin. 16. A composition according to claim 9, where the composition, in addition to the at least one flavonoid and the at least one active substance, further comprises 3-(4′-methylbenzylidene)-dl-camphor, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 2-hydroxy-4-methoxybenzophenone, ethylhexyl methoxycinnamate, 3,3,5-trimethylcyclohexyl salicylate, 2-ethylhexyl 4-(di-methylamino)benzoate, 2-ethylhexyl 2-cyano-3,3-diphenylacrylate, 2-phenylbenzimidazole-5-sulfonic acid, or a potassium, sodium or triethanolamine salt thereof. 17. A composition according to claim 9, wherein the ratio of the 1,3,4-trihydroxy-2-butanone to flavonoid is 5:1 to 1:2. 18. A composition according to claim 9, wherein the ratio of the self-tanning substance to flavonoid is 2:1. 19. A composition for the preparation of a composition according to claim 9, wherein at least one flavonoid and at least one active substance are mixed successively with a cosmetically or dermatologically suitable vehicle. 20. A method for the protection of skin comprising topically applying a composition according to claim 9. 21. A kit consisting of a two-chamber system with pump device for application of a composition according to claim 9, where the flavonoid and the self-tanning substance and further active substances and assistants are located in two separate chambers and are applied successively to the skin. 22. A composition according to claim 15 wherein said vitamin is vitamin A palmitate, vitamin C and/or a derivative thereof. 23. A method for the protection of body cells against oxidative stress or for reducing skin ageing comprising applying to the skin of a person in need thereof a composition according to claim 15. 24. A method according to claim 1, wherein the flavonoid is rutin, rutin sulfate, troxerutin and/or isoquercetin. 25. A method according to claim 6, wherein the total amount of flavonoid is 0.1 to 5% by weight. 26. A method according to claim 3, wherein the flavonoid is rutin sulfate.
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이 특허에 인용된 특허 (4)
Kurz Thekla,DEX ; Wille Dorothee,DEX ; Hitzel Sabine,DEX, Dispersion of inorganic UV filters.
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