Compositions and medical devices utilizing bioabsorbable liquid polymers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-031/74
A61K-031/765
A61K-047/30
A61K-031/56
출원번호
US-0952232
(2007-12-07)
등록번호
US-8623413
(2014-01-07)
발명자
/ 주소
Nathan, Aruna
Rosenblatt, Joel
Arnold, Steven C.
출원인 / 주소
Ethicon, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
59
초록▼
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less t
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
대표청구항▼
1. A medical device, comprising: a synthetic, bioabsorbable, biocompatible polymer comprising the reaction product of at least one polybasic acid selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, gl
1. A medical device, comprising: a synthetic, bioabsorbable, biocompatible polymer comprising the reaction product of at least one polybasic acid selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid, fumaric acid, maleic acid, maleic anhydride, mixed anhydrides, esters, activated esters and acid halides and at least one monoglyceride selected from the group consisting of monostearyl glycerol, monopalmitoyl glycerol, monomyrisitol glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauryl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, said polymer comprising an aliphatic polyester backbone having pendant fatty acid ester groups and said polymer having a melting point less than or equal to 25° C., as determined by differential scanning calorimetry. 2. The medical device of claim 1 wherein said polymer comprises a copolymer. 3. The medical device of claim 2 wherein said copolymer comprises the reaction product of said monoglyceride and at least two of said polybasic acids. 4. The medical device of claim 2 wherein said copolymer comprises the reaction product of said polybasic acid, and at least two of said monoglycerides. 5. The medical device of claim 1 further comprising an effective amount of a bioactive agent. 6. The medical device of claim 1 further comprising end capping-moieties selected from the group consisting of alkyls, alkenyls, alkynyls, acrylates, methacrylates, amines, isocyanates and isothiocyanates. 7. The medical device of claim 1 wherein the polymer is a soft tissue repair material. 8. The medical device of claim 1 wherein the polymer is a soft tissue augmentation material. 9. The medical device of claim 1 comprising a coating of said polymer. 10. The medical device of claim 9 wherein the surgical article is selected from the group consisting of sutures, stents, needles, vascular grafts, stent-graft combinations, meshes, tissue engineering scaffolds, pins, clips, staples, films, sheets, foams, anchors, screws and plates. 11. A medical device comprising: a synthetic, bioabsorbable, biocompatible polymer comprising the reaction product of succinic anhydride or succinic acid and at least one monoglyceride selected from the group consisting of monostearyl glycerol, monopalmitoyl glycerol, monomyrisitol glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauryl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, said polymer comprising an aliphatic polyester backbone having pendant fatty acid ester groups and said polymer having a melting point less than about 25° C., as determined by differential scanning calorimetry. 12. A medical device, comprising: a synthetic, bioabsorbable, biocompatible polymer comprising the reaction product of at least one polybasic acid selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid, sebacic acid, fumaric acid, maleic acid, maleic anhydride, mixed anhydrides, esters, activated esters and acid halides, at least one monoglyceride selected from the group consisting of monostearyl glycerol, monopalmitoyl glycerol, monomyrisitol glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauryl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, and at least one polyol selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,3-propanediol, bis-2-hydroxyethyl ether, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, other diols, linear poly(ethylene glycol), branched poly(ethylene glycol), linear poly(propylene glycol), branched poly(propylene glycol), linear poly(ethylene-co-propylene glycol)s and branched poly(ethylene-co-propylene glycol)s, said polymer comprising an aliphatic polyester backbone having pendant fatty acid ester groups and said polymer having a melting point less than or equal to 25° C., as determined by differential scanning calorimetry.
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