Immunogenical complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/70
A61K-039/00
A61K-039/295
A61K-039/116
출원번호
US-0066489
(2006-09-12)
등록번호
US-8642258
(2014-02-04)
우선권정보
BR-0503817 (2005-09-12)
국제출원번호
PCT/BR2006/000182
(2006-09-12)
§371/§102 date
20080721
(20080721)
국제공개번호
WO2007/030901
(2007-03-22)
발명자
/ 주소
Pacheco, Ogari
Sant'Anna, Osvaldo Augusto
Mercure, Lucildes
Matos, Jivaldo
Fantini, Márcia
출원인 / 주소
Cristalia Produtos Quimicos Farmaceuticos Ltda.
대리인 / 주소
Birch, Stewart, Kolasch & Birch, LLP
인용정보
피인용 횟수 :
0인용 특허 :
2
초록▼
The present invention relates to a product named “immunogenical complex”, which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants.
The present invention relates to a product named “immunogenical complex”, which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants. The immunogenical complex of the present invention allows the presentation of the antigens that compose it to lymphocytes, in a safe, gradual and extended way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. This ensures an efficient immunological protection with fewer amounts of antigens and/or less repetitions of vaccinal doses. In addition, the characteristics of the immunogenical complex of the present invention promotes effective immunity induction, homogeneous in “god and bad respondent” individuals.
대표청구항▼
1. An immunogenic complex consisting essentially of i) particles of ordered nanostructured mesoporous silica, having pores of 2 to 50 nm in diameter, and ii) at least one antigen, wherein the proportion of antigen to silica particles is 1:5 to 1:50 and the antigen is encapsulated by the particles of
1. An immunogenic complex consisting essentially of i) particles of ordered nanostructured mesoporous silica, having pores of 2 to 50 nm in diameter, and ii) at least one antigen, wherein the proportion of antigen to silica particles is 1:5 to 1:50 and the antigen is encapsulated by the particles of mesoporous silica, which act as an adjuvant for immunization. 2. The immunogenic complex according to claim 1, wherein the at least one antigen is selected from the group consisting of proteins, biologically active peptides, toxins, viruses and bacteria. 3. The immunogenic complex according to claim 2, wherein the antigen is a bacterial protein antigen or a viral protein antigen. 4. The immunogenic complex according to claim 1, wherein the ordered nanostructured mesoporous silica is a SBA-15 mesoporous silica. 5. The immunogenic complex according to claim 1, wherein the proportion of antigen to silica particles is 1:25. 6. The immunogenic complex of claim 1, that provides prolonged presentation of antigen to lymphocytes and results in improved immunologic memory response. 7. A vaccine comprising the immunogenic complex of claim 1, and a pharmaceutically acceptable carrier, diluent or excipient. 8. A method for producing an immunogenic complex comprising mixing particles of ordered nanostructured mesoporous silica, having pores of 2 to 50 nm in diameter, with at least one antigen, wherein the antigen and silica particles are mixed in a ratio of 1:5 to 1:50, whereby the antigen is enbapsulated by the particles of mesoporous silica, which act as an adjuvant for immunization. 9. The method according to claim 8, wherein the at least one antigen is selected from the group consisting of proteins, biologically active peptides, toxins, viruses and bacteria. 10. The method according to claim 9, wherein the antigen is a bacterial protein antigen or viral protein antigen. 11. The method according to claim 8, wherein the highly ordered nanostructured mesoporous silica is a SBA-15 mesoporous silica. 12. The immunogenic complex according to claim 1, in which the pores of the mesoporous silica are hexagonally close packed.
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이 특허에 인용된 특허 (2)
Kresge Charles T. (West Chester PA) Leonowicz Michael E. (Medford Lakes NJ) Roth Wieslaw J. (Sewell NJ) Vartuli James C. (West Chester PA), Composition of synthetic porous crystalline material, its synthesis.
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