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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0569350 (2009-09-29) |
등록번호 | US-8650751 (2014-02-18) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 453 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agen
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
1. A method of manufacturing a plurality of electrochemical sensors, the method comprising the steps of: forming a plurality of individual working electrodes on a first electrode region of a first substrate;forming a plurality of individual counter electrodes on a second electrode region of a second
1. A method of manufacturing a plurality of electrochemical sensors, the method comprising the steps of: forming a plurality of individual working electrodes on a first electrode region of a first substrate;forming a plurality of individual counter electrodes on a second electrode region of a second substrate;positioning a spacer layer comprising a release liner on one of the first and the second electrode regions;following positioning of the spacer layer, removing the release liner to remove a portion of the spacer layer to define sample chamber regions;overlaying the first substrate with the second substrate to form a layered structure; andseparating the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region. 2. The method according to claim 1, wherein the working electrodes comprise a material selected from the group consisting of gold, carbon, platinum, ruthenium dioxide, and palladium. 3. The method according to claim 1, wherein the counter electrodes comprise a material selected from the group consisting of gold, carbon, platinum, ruthenium dioxide, and palladium. 4. The method according to claim 1, wherein the step of forming a plurality of working electrodes comprises printing a plurality of working electrodes, and wherein the step of forming a plurality of counter electrodes comprises printing a plurality of counter electrodes. 5. The method according to claim 4, wherein printing a plurality of working electrodes comprises printing a carbon ink. 6. The method according to claim 4, wherein printing a plurality of working electrodes comprises printing a palladium ink. 7. The method according to claim 4, wherein printing a plurality of counter electrodes comprises printing a Ag/AgCl ink. 8. The method according to claim 4, wherein printing a plurality of counter electrodes comprises printing a gold ink. 9. The method according to claim 1, further comprising forming a plurality of indicator electrodes on the substrate, wherein the step of separating the layered structure into a plurality of electrochemical sensors comprises separating the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, at least one indicator electrode, and at least one sample chamber. 10. The method according to claim 1, further comprising depositing an enzyme over a portion of the working electrodes. 11. The method according to claim 10, wherein the analyte is glucose, and wherein the enzyme is selected from the group consisting of glucose dehydrogenase, and glucose oxidase. 12. The method according to claim 1, further comprising depositing a redox mediator over a portion of the working electrodes. 13. The method according to claim 12, wherein the redox mediator comprises a transition metal complex comprising a metal selected from the group consisting of osmium, ruthenium, iron, and cobalt. 14. The method according to claim 13, wherein the transition metal complex comprises osmium. 15. A method of manufacturing a plurality of electrochemical sensors, the method comprising the steps of: forming a plurality of individual working electrodes on a first electrode region of a first substrate;forming a plurality of individual counter electrodes on a second electrode region of a second substrate;positioning a spacer layer comprising a release liner on one of the first electrode region and the second electrode regions;following positioning of the spacer layer, removing the release liner to remove a portion of the spacer layer to define sample chamber regions;overlaying the first substrate with the second substrate to form a layered structure; andcutting the layered structure to provide individual electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region, wherein at least one end of the at least one sample chamber region is defined by a cut. 16. The method according to claim 15, wherein the working electrodes comprise a material selected from the group consisting of gold, carbon, platinum, ruthenium dioxide, and palladium. 17. The method according to claim 15, wherein the counter electrodes comprise a material selected from the group consisting of gold, carbon, platinum, ruthenium dioxide, and palladium. 18. The method according to claim 15, wherein the step of forming a plurality of working electrodes comprises printing a plurality of working electrodes, and wherein the step of forming a plurality of counter electrodes comprises printing a plurality of counter electrodes. 19. The method according to claim 18, wherein printing a plurality of working electrodes comprises printing a carbon ink. 20. The method according to claim 18, wherein printing a plurality of working electrodes comprises printing a palladium ink. 21. The method according to claim 18, wherein printing a plurality of counter electrodes comprises printing a Ag/AgCl ink. 22. The method according to claim 18, wherein printing a plurality of counter electrodes comprises printing a gold ink. 23. The method according to claim 15, further comprising forming a plurality of indicator electrodes on the substrate, wherein the step of cutting the layered structure to provide individual electrochemical sensors comprises cutting the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, at least one indicator electrode, and at least one sample chamber. 24. The method according to claim 15, further comprising depositing an enzyme over a portion of the working electrodes. 25. The method according to claim 24, wherein the analyte is glucose, and wherein the enzyme is selected from the group consisting of glucose dehydrogenase, and glucose oxidase. 26. The method according to claim 15, further comprising depositing a redox mediator over a portion of the working electrodes. 27. The method according to claim 26, wherein the redox mediator comprises a transition metal complex comprising a metal selected from the group consisting of osmium, ruthenium, iron, and cobalt. 28. The method according to claim 27, wherein the transition metal complex comprises osmium.
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