A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprisin
A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-β, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
대표청구항▼
1. An implantable bone paste composition, for use in a recipient in need thereof, comprising a mixture of gelatin, osteogenic demineralized bone matrix (DBM) and, optionally, one or more additional substantially bioabsorbable, osteogenic components, wherein the optional osteogenic component is selec
1. An implantable bone paste composition, for use in a recipient in need thereof, comprising a mixture of gelatin, osteogenic demineralized bone matrix (DBM) and, optionally, one or more additional substantially bioabsorbable, osteogenic components, wherein the optional osteogenic component is selected from the group consisting of: bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof, andwherein DBM is present at a concentration of from 24% (w/w) to 33% (w/w). 2. The composition of claim 1 wherein said composition gels at about 38° C. 3. The composition of claim 1, which is a frozen solution or is freeze-dried. 4. The composition of claim 1, wherein the demineralized bone matrix is in a powdered form, and is composed of particles in the size range between about 80-850μm in diameter. 5. An implantable bone paste composition, for use in a recipient in need thereof, consisting of a mixture of gelatin, osteogenic demineralized bone matrix (DBM), and optionally, a reconstitution solution, and/or one or more substantially bioabsorbable, osteogenic components, wherein the optional osteogenic component is selected from the group consisting of: bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof, and wherein DBM is present at a concentration of from 24% (w/w) to 33% (w/w). 6. The composition of claim 1, wherein said gelatin is present at a concentration of from about 20% (w/w) to about 45% (w/w). 7. The composition of claim 1, comprising at least one osteogenic component selected from the group consisting of: bioactive glass ceramic, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, bone morphogenetic protein, TGF-beta, PDGF, and mixtures thereof. 8. The composition of claim 7, comprising bioactive glass ceramic and/or bone morphogenetic protein. 9. The composition of claim 3, which is a frozen solution. 10. The composition of claim 3, which is freeze-dried. 11. The composition of claim 5, wherein said gelatin is present at a concentration of from about 20% (w/w) to about 45% (w/w). 12. The composition of claim 5, wherein the demineralized bone matrix is in a powdered form, and is composed of particles in the size range between about 80-850 μm in diameter. 13. The composition of claim 5, wherein said composition gels at about 38° C. 14. The composition of claim 5, which is a frozen solution. 15. The composition of claim 5, which is freeze-dried.
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이 특허에 인용된 특허 (25)
Kuberasampath Thangavel (Medway MA) Ridge Richard J. (Acton MA), Bone collagen matrix for implants.
Scheicher Hans (Rondell Neuwittelsbach 4 D-8000 Munich DEX), Corrective agent for the covering and/or filling of bone defects, method for the preparation of same and method of using.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA), Demineralized bone particles and flowable osteogenic composition containing same.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA), Process for producing flowable osteogenic composition containing demineralized bone particles.
Tardy Michel (Lyons FRX) Tayot Jean-Louis (La Tour de Salvagny FRX), Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the appl.
Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the.
Ammann Arthur J. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Beck Steven L. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Nguyen Tue H. (460 Point San Bruno Blvd. So, TGF-b
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Pfirrmann Rolf W. (Lucerne CHX), Treatment of osteitis.
Bhat, Archana; Kunjachan, Vipin; Geisler, Chris; Adams, Allison; Grimes, Christine, Biomaterial compositions, implants, and methods of making the same.
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