IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0662775
(2012-10-29)
|
등록번호 |
US-8655444
(2014-02-18)
|
우선권정보 |
IL-116699 (1996-01-08); IL-119261 (1996-09-17) |
발명자
/ 주소 |
- Ben-Haim, Shlomo
- Darvish, Nissim
- Fenster, Maier
- Mika, Yuval
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
8 인용 특허 :
235 |
초록
▼
A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activation, and applying a non-excitatory electric field having a given duration, at a delay after the activation, to the por
A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activation, and applying a non-excitatory electric field having a given duration, at a delay after the activation, to the portion, which causes the force of contraction to be increased by a least 5%.
대표청구항
▼
1. A method of cardiac reshaping, comprising: determining a desired target change in distribution of muscle mass in a heart; andapplying one or more non-excitatory electric fields to the heart such that said distribution is changed, at least in part, thereby. 2. A method according to claim 1, compri
1. A method of cardiac reshaping, comprising: determining a desired target change in distribution of muscle mass in a heart; andapplying one or more non-excitatory electric fields to the heart such that said distribution is changed, at least in part, thereby. 2. A method according to claim 1, comprising sensing at least one cardiac parameter by a sensor and modifying said applying, in response to said sensing. 3. A method according to claim 1, wherein said applying comprises applying using a device with plurality of electrodes and selecting a subset of said plurality of electrodes for said applying, based on said determining. 4. A method according to claim 1, wherein said applying comprises applying for at least two weeks. 5. A method according to claim 1, wherein said determining comprises selecting a frequency of application, so said applying comprises applying not at every beat. 6. A method according to claim 1, comprising modifying said desired target distribution after a few weeks from an initiation of said applying. 7. A method according to claim 1, wherein said applying comprises modifying one or both of a preload and an afterload of the heart. 8. A method according to claim 4, wherein said modifying is in response to an adaptation of the heart to said applying or as a function of time. 9. A method according to claim 1, comprising modifying said applying in response to a change in the heart. 10. A method according to claim 1, comprising periodically varying said applying. 11. A method according to claim 1, comprising stopping said applying in response to reaching said target. 12. A method according to claim 1, wherein said applying comprises directly modifying a workload on a segment of the heart. 13. A method according to claim 1, wherein said applying comprises indirectly modifying a workload on a segment of the heart. 14. A method according to claim 1, wherein said applying comprises modifying a stress on a segment of the heart. 15. A method according to claim 1, wherein said applying comprises modifying a duration of an action potential plateau of a segment of the heart. 16. A method according to claim 1, wherein said applying comprises modifying a contractility of a segment of the heart. 17. A method according to claim 1, wherein said applying comprises redistributing one or more local physiological values. 18. A method according to claim 1, wherein said applying comprises increasing cardiac output. 19. A method according to claim 1, comprising also controlling arrhythmia using one or more non-excitatory electric fields. 20. A method according to claim 1, comprising storing a long-term therapeutic goal in a memory of a controller which controls said applying. 21. A method according to claim 1, wherein redistributing comprises increasing muscle mass at a desired location. 22. A method according to claim 1, comprising changing a location of electrodes used to provide said applying responsive to said desired target. 23. A method according to claim 1, comprising increasing an efficiency of said heart by said applying. 24. A method according to claim 1, comprising strengthening said heart by said applying. 25. A method according to claim 1, comprising selection a desired activation profile to be created by said applying. 26. A method according to claim 25, wherein said activation profile includes a change in one or more of conduction pattern, or distribution and timing of activation. 27. Implantable apparatus for cardiac reshaping programmed to perform the applying of claim 1.
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