An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method
An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
대표청구항▼
1. An osteoimplant which comprises a coherent aggregate of elongate bone particles selected from the group consisting of substantially fully demineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures there
1. An osteoimplant which comprises a coherent aggregate of elongate bone particles selected from the group consisting of substantially fully demineralized elongate bone particles, partially demineralized elongate bone particles, superficially demineralized elongate bone particles, and mixtures thereof, wherein mutually contacting elongate bone particles are mechanically entangled with each other, the coherent aggregate of elongate bone particles being shaped in a mold to predetermined dimensions in the substantial absence of pressure or mechanical shaping forming an open pore, sponge-like structure, wherein the open pore, sponge-like structure enables the osteoimplant to absorb fluids while generally retaining the predetermined shape. 2. The osteoimplant of claim 1 wherein the elongate bone particles represent at least about 50 weight percent of the aggregate. 3. The osteoimplant of claim 1 wherein the elongate bone particles represent at least about 60 weight percent of the aggregate. 4. The osteoimplant of claim 1 wherein the elongate bone particles represent at least about 90 weight percent of the aggregate. 5. The osteoimplant of claim 1 wherein the aggregate further comprises non-elongate bone particles. 6. The osteoimplant of claim 5 wherein at least some of the non-elongate bone particles are substantially fully mineralized, substantially fully demineralized, partially demineralized or superficially demineralized. 7. The osteoimplant of claim 1 wherein the elongate bone particles are obtained from cortical, cancellous, corticocancellous allogenic, xenogenic or transgenic bone tissue. 8. The osteoimplant of claim 1 wherein the elongate bone particles possess the capability to facilitate or accelerate new bone growth by at least one of osteogenesis, osteoconduction and osteoinduction. 9. The osteoimplant of claim 1 wherein the median length of the elongate bone particles is from about 2 to about 200 mm, the median width of the elongate bone particles is from about 0.05 to about 50 mm and the ratio of median length to median width is from about 10:1 to about 2000:1. 10. The osteoimplant of claim 1 wherein the median length of the elongate bone particles is from about 1 to about 100 mm, the median width of the elongate particles is from about 0.1 to about 20 mm and the ratio of median length to median width is from about 20:1 to about 600:1. 11. The osteoimplant of claim 1 wherein at least some of the elongate bone particles are substantially fully demineralized. 12. The osteoimplant of claim 1 wherein elongate bone particles are admixed with one or more of the group consisting of binders/fillers, plasticizers, biostatic/biocidal agents, bioactive substances, surface active agents prior to, during and/or after forming the aggregate into the osteoimplant. 13. The osteoimplant of claim 12 wherein the binder/filler is selected from the group consisting of cyanoacrylates, epoxy-based compounds, dental resin sealants, dental resin cements, calcium phosphate and calcium sulfate self-setting cements, glass ionomer cements, polymethyl methacrylate, gelatin-resorcinol-formaldehyde glues, protein and collagen-based glues, acrylic resins, cellulosics, bioabsorbable polymers such as polyglycolide, polylactide, glycolide-lactide copolymers, polycaprolactone, polyanhydrides, polycarbonates, polyorthoesters, polyamino acids, polyarylates, polycyanoacrylates, polyhydroxybutyrate, polyhydroxyvalyrate, polyphosphazenes, polyvinylpyrrolidone, polyarylates, tyrosine-based polycarbonates and polyarylates, carbohydrate polymers, polyiminocarbonates, polypropylene fumarates, polyanhydride esters, polytetrafluroethylene, hexacryl, Hyaluronic acid, fibrin, fibrin-collagen, polyethylene glycol glues, mucopolysaccharides and mussel adhesive proteins, fatty acids and fatty acid derivatives. 14. The osteoimplant of claim 12 wherein the binder/filler is selected from the group consisting of bone powder, demineralized bone powder, porous calcium phosphate ceramics, hydroxyapatite, tricalcium phosphate, Bioglass.RTM. and other calcium phosphate materials, calcium sulfate or calcium carbonate particles. 15. The osteoimplant of claim 12 wherein the plasticizer is selected from the group liquid polyhydroxy compound. 16. The osteoimplant of claim 15 wherein the liquid polyhydroxy compound is glycerol. 17. The osteoimplant of claim 12 wherein the biostatic/biocidal agent is selected from the group consisting of antibiotics, povidone, sugars and mucopolysaccharides. 18. The osteoimplant of claim 12 wherein the surface-active agent is selected from the group consisting of biocompatible nonionic, cationic, anionic and amphoteric surfactant. 19. The osteoimplant of claim 12 wherein the bioactive substance is selected from the group consisting of trophic factors, analgesics, anti-cancer agents, vaccines, adjuvants, antibodies, neuroleptics, cells or cellular components, collagen, insoluble collagen derivatives, and soluble solids and/or liquids dissolved therein, antiviricides; antimicrobials and/or antibiotics; biocidal/biostatic sugars; amino acids, peptides, vitamins, inorganic elements, co-factors for protein synthesis; hormones; endocrine tissue or tissue fragments, synthesizers; enzymes, polymer cell scaffolds with parenchymal cells, angiogenic drugs and polymeric carriers containing such drugs; collagen lattices; antigenic agents; cytoskeletal agents; cartilage fragments, modified living cells, natural extracts, genetically engineered living cells, DNA delivered by plasmid or viral vectors, tissue transplants, demineralized bone powder, autogenous tissues, blood, serum, soft tissue, bone marrow, bioadhesives; non-collagenous proteins, osteopontin, osteonectin, bone sialo protein, laminin, fibrinogen, vitronectin, thrombospondin, proteoglycans, decorin, beta glycan, biglycan, aggrecan, versican, tenascin, matrix gla protein, hyaluronan, amino acids, amino acid residues, peptides, bone morphogenic proteins (BMPs); osteoinductive factor (OIF); fibronectin (FN); endothelial cell growth factor (ECGF); cementum attachment extracts (CAE); ketanserin; human growth hormone (HGH); animal growth hormones; epidermal growth factor (EGF); interleukin-1 (L-1); human alpha thrombin; transforming growth factor (TGF-beta); insulin-like growth factor (IGF-1) (IGF-2); platelet derived growth factors (PDGF); fibroblast growth factors (FGF, aFGF, bFGF, etc.); periodontal ligament chemotactic factor (PDLGF); somatotropin; bone digestors; antitumor agents; immuno-suppressants; fatty acids; permeation enhancers, fatty acid esters, laureate, myristate and stearate monoesters of polyethylene glycol, enamine derivatives, alpha-keto-aldehydes, and nucleic acids; inorganic elements, inorganic compounds, cofactors for protein synthesis, hormones, soluble and insoluble components of the immune system; soluble and insoluble receptors; soluble, insoluble and cell surface bound ligands; chemokines, bioactive compounds that are endocytosed; endocrine tissue or tissue fragments, growth factor binding proteins, insulin-like growth factor binding protein (IGFBP-2) (IGFBP-4) (IGFBP-5) (IGFBP-6); angiogenic agents, bone promoters, cytokines, interleukins, genetic material, genes encoding bone promoting actions, cells containing genes encoding bone promoting action; growth hormones; bone digestors; antiumor agents; cellular attractants and attachment agents; immunosuppressants; bone resorption inhibitors and stimulators; angiogenic and mitogenic factors; bioactive factors that inhibit and stimulate secondary messenger molecules; cell adhesion molecules, cell-matrix and cell-cell adhesion molecules; secondary messengers, monoclonal antibodies specific to cell surface determinants on mesenchymal stem cells, clotting factors; externally expanded autograft or xenograft cells, nucleic acids and any combination thereof. 20. The osteoimplant of claim 1 wherein the elongate bone particles are in the lyophilized state. 21. The osteoimplant of claim 1 wherein the elongate bone particles are cross-linked. 22. The osteoimplant of claim 1 possessing regions one of which comprises demineralized elongate bone particles and another of which comprises nondemineralized elongate bone particles. 23. The osteoimplant of claim 22 wherein the region of demineralized elongate bone particles defines at least a portion of the exterior surface of the osteoimplant and the region of mineralized elongate bone particles defines at least a portion of core of the osteoimplant. 24. The osteoimplant of claim 1 possessing a bulk density of not greater than about 0.3 g/cm. 25. The osteoimplant of claim 1 in the shape of a sheet, plate, disk, cone, pin, screw, tube, tooth, tooth root, plug, bone or portion of bone, wedge or portion of wedge, cylinder or threaded cylinder. 26. The osteoimplant of claim 1 possessing at least one recess therein. 27. The osteoimplant of claim 1 wherein the elongate bone particles possess a ratio of median length to median width of from about 10:1 to about 2000:1. 28. The osteoimplant of claim 1 wherein the elongate bone particles possess a ratio of median length to median width of from about 20:1 to about 600:1. 29. The osteoimplant of claim 1 wherein the osteoimplant is configured for use in posterolateral procedures. 30. An implant for bone repair possessing at least one cavity containing the osteoimplant of claim 1. 31. The implant of claim 30 which is an intervertebral implant. 32. The implant of claim 30 which is a fusion cage.
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Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
Redl Heinz (Vienna ATX) Schlag Gnther (Vienna ATX) Pridun Nestor (Vienna ATX), Biologic absorbable implant material for filling and closing soft tissue cavities and method of its preparation.
Gross Albert (Frankfurt am Main DT) Schaefer Roland (Friedrichsdorf ; Taunus DT) Reiss Siegfried (Bad Homburg DT), Bone cement compositions containing gentamycin.
Trml Pertti (Tampere FIX) Rokkanen Pentti (Helsinki FIX) Oikarinen Valle J. (Helsinki FIX) Vainionp Seppo (Helsinki FIX) Helevirta Pertti (Tampere FIX), Bone graft implant.
Abdul-Malak Nabil (27 ; rue Frederic Mistral 69300 Caluire FRX) Fourcart Jean (Place de l\Orme Baslieux les Fismes 51170 Fismes FRX) Huc Alain (26 ; chemin des Santons 69110 Ste Foy les Lyon FRX), Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane,.
Dorman Linneaus C. (Midland MI) Meyers Paul A. (Dublin CA), Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics.
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Scheicher Hans (Rondell Neuwittelsbach 4 D-8000 Munich DEX), Corrective agent for the covering and/or filling of bone defects, method for the preparation of same and method of using.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA), Demineralized bone particles and flowable osteogenic composition containing same.
Eitenmuller Jurgen (Brauweiler DEX) Offergeld Heinz (Monchen-Gladbach DEX) Michaeli Walter (Aachen DEX), Device for osteosynthesis and process for producing it.
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Los Gatos CA) Chu George H. (Cupertino CA) Hendericks Diana M. (Brea CA) Brown Debera (Palo Alto CA), Gamma irradiation of collagen/mineral mixtures.
Wang Kathy K. (Suffern NY) Gustavson Larry J. (Dover NJ) Dumbleton John H. (Ridgewood NJ), High strength, low modulus, ductile, biopcompatible titanium alloy.
Lazarow Normand H. (Rochester MN) Bove Alfred A. (Rochester MN), Imaging system and method using radiopaque microspheres for evaluation of organ tissue perfusion.
Wahlig Helmut (Darmstadt DEX) Dingeldein Elvira (Dreieich DEX) Braun Dietrich (Darmstadt DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Morris,John; Shimp,Lawrence A.; Petersen,Kenneth C.; Manrique,Albert; Kaes,David; Scarborough,Nelson; Dowd,Michael, Method of making demineralized bone particles.
Campbell Todd D. (Corona CA) Nashef Aws S. (Costa Mesa CA), Method of producing prostheses for replacement of articular cartilage and prostheses so produced.
Scantlebury Todd V. (Flagstaff AZ) Ambruster Jeanne B. (Flagstaff AZ) Motsinger Suzanne (Flagstaff AZ) Davidson Daniel F. (Flagstaff AZ) Hardwick William R. (Flagstaff AZ) Campbell Stephen E. (Cave C, Methods and articles for treating periodontal disease and bone defects.
Damani Nalinkant C. (Cincinnati OH) Mohl Douglas C. (Fairfield OH) Singer ; Jr. Robert E. (Fairfield OH), Methods for aiding periodontal tissue regeneration.
Petrie Charles ; Orme Mark W. ; Baindur Nand ; Robbins Kirk G. ; Hurley Laurence H. ; Kerwin Sean M. ; Mundy Gregory R., Methods for treating bone deficit conditions with benzothiazole.
Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Oppermann Hermann (Medway MA) Cohen Charles M. (Medway MA) Pang Roy H. L. (Etna NH), Morphogen induced periodontal tissue regeneration.
Scarborough Nelson L. ; Morris John W. ; Russell James L. ; Dowd Michael, Pressure flow system and method for treating a fluid permeable workpiece such as a bone.
Michael Dowd ; Nelson L. Scarborough ; Mark Daugherty ; Jack McMickle, Process for producing flexible sheets from demineralized, elongate, bone particles.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA), Process for producing flowable osteogenic composition containing demineralized bone particles.
Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Syftestad Glenn T. (3660 Warrensville Center Rd. #101 Shaker Heights OH 44122), Process of adapting soluble bone protein for use in stimulating osteoinduction.
Thiele Heinrich (Neue Universitaet Kiel DEX) Thiele Erhard (Reventlow-Allee 9 23 Kiel DEX), Process of degrading and regenerating bone and tooth material and products.
Glowczewskie ; Jr. Frank P. (Gainesville IL) Present David A. (New York NY) Anderson David W. (New York NY) McBrayer Patrick A. (Yardley PA), Reconstitution of human bone and tissue.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA) Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Shaped, swollen demineralized bone and its use in bone repair.
Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA) Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Shaped, swollen demineralized bone and its use in bone repair.
Boguslaski Robert C. (Elkhart IN) Carrico Robert J. (Elkhart IN) Christner James E. (Ann Arbor MI), Specific binding assay with an enzyme modulator as a labeling substance.
Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Swollen demineralized bone particles, flowable osteogenic composition containing same and use of the composition in the.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
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