A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating sys
A coating for implantable medical devices and a method for fabricating thereof are disclosed. The coating includes a mixture of a hydrophobic polymer and a polymeric hydrophilic additive, wherein the hydrophobic polymer and the hydrophilic additive form a physically entangled or interpenetrating system.
대표청구항▼
1. A medical article comprising an implantable substrate and a coating, the coating comprising: a bulk polymer selected from a group consisting of a poly(meth)acrylate, a vinyl polymer, a halogenated polymer, and a polymer having urethane groups;an additive polymer in less quantity in the coating th
1. A medical article comprising an implantable substrate and a coating, the coating comprising: a bulk polymer selected from a group consisting of a poly(meth)acrylate, a vinyl polymer, a halogenated polymer, and a polymer having urethane groups;an additive polymer in less quantity in the coating than the bulk polymer, the additive polymer being entangled with the bulk polymer; anda drug;wherein the bulk polymer has an equilibrium water adsorption less than about 10 mass % at room temperature;wherein the poly(meth)acrylate is poly(n-propyl methacrylate), poly(iso-propyl methacrylate), poly(n-propyl acrylate), poly(iso-propyl acrylate), poly(n-butyl acrylate), poly(iso-butyl acrylate), or a mixture thereof;wherein the vinyl polymer is poly(ethylene-co-vinyl acetate), poly(styrene-co-iso-butylene), poly(styrene-co-ethylene-co-butylene-co-styrene) terpolymer, poly(styrene-co-butadiene-co-styrene) terpolymer, or a mixture thereof;wherein the halogenated polymer is poly(vinyl fluoride), poly(vinylidene fluoride), polyhexafluoropropene, poly(hexafluoropropene-co-vinylidene fluoride), poly(ethylene-co-hexafluoropropene), poly(vinyl chloride), poly(vinylidene chloride), or a mixture thereof;wherein the polymer having urethane groups is a polyurethaneurea, a silicone urethane, or a mixture thereof;wherein the additive polymer is chondroitan sulfate, a glucosaminoglucan, dextrin, dextran sulfate, or a mixture thereof, or poly(trimethylene glycol), poly(tetramethylene glycol), or a mixture thereof; andwherein the ratio of the bulk polymer to the additive polymer is about 74:1 to about 14:1. 2. The medical article of claim 1, wherein the ratio of the bulk polymer to the additive polymer is about 49:1 to about 19:1. 3. The medical article of claim 1, wherein the bulk polymer is more hydrophobic than the additive polymer. 4. The medical article of claim 1, wherein the bulk polymer is a poly(meth)acrylate selected from the group consisting of poly(n-propyl methacrylate), poly(iso-propyl methacrylate), poly(n-propyl acrylate), poly(iso-propyl acrylate), poly(n-butyl acrylate), poly(iso-butyl acrylate), and mixtures thereof. 5. The medical article of claim 1, wherein the additive polymer is selected from the group consisting of poly(trimethylene glycol), poly(tetramethylene glycol), and mixtures thereof. 6. The medical article of claim 1, wherein the bulk polymer has a Hildebrand solubility parameter lower than 10.7 (cal/cm3)1/2. 7. The medical article of claim 1, wherein the bulk polymer is a vinyl polymer. 8. The medical article of claim 1, wherein the bulk polymer is a halogenated polymer. 9. The medical article of claim 1, wherein the bulk polymer is a polymer having urethane groups. 10. The medical article of claim 1, wherein the article is a stent. 11. The medical article of claim 1, wherein the drug is selected from the group consisting of rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, and combinations thereof. 12. The medical article of claim 1, wherein the vinyl polymer is poly(styrene-co-iso-butylene), poly(styrene-co-ethylene-co-butylene-co-styrene) terpolymer, poly(styrene-co-butadiene-co-styrene) terpolymer, or a mixture thereof. 13. The medical article of claim 1, wherein the halogenated polymer is poly(vinyl fluoride), poly(vinylidene fluoride), poly(vinyl chloride), poly(vinylidene chloride), or a mixture thereof. 14. The medical article of claim 1, wherein the halogenated polymer is polyhexafluoropropene, poly(hexafluoropropene-co-vinylidene fluoride), poly(ethylene-co-hexafluoropropene), poly(vinyl chloride), poly(vinylidene chloride), or a mixture thereof. 15. The medical article of claim 1, wherein the additive polymer is chondroitan sulfate, a glucosaminoglucan, dextrin, dextran sulfate, or a mixture thereof. 16. A medical article comprising an implantable substrate and a coating, the coating comprising: a bulk polymer selected from a group consisting of poly(styrene-co-iso-butylene), poly(styrene-co-ethylene-co-butylene-co-styrene) terpolymer, poly(styrene-co-butadiene-co-styrene) terpolymer, and a mixture thereof;an additive polymer in less quantity in the coating than the bulk polymer, the additive polymer being entangled with the bulk polymer; anda drug;wherein the bulk polymer has an equilibrium water adsorption less than about 10 mass % at room temperature;wherein the additive polymer is chondroitan sulfate, a glucosaminoglucan, dextrin, dextran sulfate, carboxymethyl cellulose, a cellulosic, poly(ethylene amine), poly(allyl amine), a non-ionic tetrafunctional block-copolymer surfactant, gelatin, collagen, albumin, chitin, elastin, fibrin, or a mixture thereof, or poly(trimethylene glycol), poly(tetramethylene glycol), or a mixture thereof; andwherein the ratio of the bulk polymer to the additive polymer is about 74:1 to about 14:1. 17. The medical article of claim 16, wherein the ratio of the bulk polymer to the additive polymer is about 49:1 to about 19:1. 18. The medical article of claim 16, wherein the bulk polymer is more hydrophobic than the additive polymer. 19. The medical article of claim 16, wherein the additive polymer is selected from the group consisting of poly(trimethylene glycol), poly(tetramethylene glycol), and mixtures thereof. 20. The medical article of claim 16, wherein the bulk polymer has a Hildebrand solubility parameter lower than 10.7 (cal/cm3)1/2. 21. The medical article of claim 16, wherein the article is a stent. 22. The medical article of claim 16, wherein the drug is selected from the group consisting of rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, and combinations thereof. 23. The medical article of claim 16, wherein the additive polymer is chondroitan sulfate, a glucosaminoglucan, dextrin, dextran sulfate, or a mixture thereof, or poly(trimethylene glycol), poly(tetramethylene glycol), or a mixture thereof.
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