IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0291814
(2008-11-13)
|
등록번호 |
US-8690120
(2014-04-08)
|
발명자
/ 주소 |
- Hartnett, Jeff
- Lofving, Alf
- Hultquist, Lars
- Davidsson, Jan
- Myhrberg, Lennart
|
출원인 / 주소 |
- EMD Millipore Corporation
|
대리인 / 주소 |
Nields, Lemack & Frame, LLC
|
인용정보 |
피인용 횟수 :
14 인용 특허 :
152 |
초록
▼
A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Par
A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component. When the device is closed, the upstream end of the plunger is in alignment with the upstream flange of the body, forming a steamable sterilized in place face and a sterile barrier.
대표청구항
▼
1. A fluid transfer device, comprising: a body comprising: a first section having a groove on a surface and a first end containing a first opening and a flange surrounding the first opening for attaching the body to a process component;a second section rotatably engaged with the first section and ha
1. A fluid transfer device, comprising: a body comprising: a first section having a groove on a surface and a first end containing a first opening and a flange surrounding the first opening for attaching the body to a process component;a second section rotatably engaged with the first section and having a second end containing a second opening; anda bore located in the interior of the body connecting the first and second openings;a linearly movable plunger movable between a closed position corresponding to a closed position of the device and an open position corresponding to an open position of the device, the linearly movable plunger being contained within the bore and having, a groove,a first portion containing a first opening and a bottom end, wherein the bottom end being in alignment with the flange surrounding the first opening of the body forms a fluid-resistant seal and a steam sterilizable face,a second portion containing a second opening,a fluid channel located in the interior of the plunger connecting the first and second openings of the plunger, anda component for inhibiting rotation of the plunger within the bore during actuation of the device; anda linear or gland seal arranged along a length of the plunger between the first opening of the plunger and the second opening of the plunger, a first portion of the linear or gland seal being retained within the groove on the surface of the first section of the body and a second portion of the linear or gland seal being retained within the groove on the plunger in sealing contact with the plunger and an inner surface of the first section of the body, wherein the plunger is linearly movable between a closed position and an open position by rotating the second section of the body; the device is in the closed position when the bottom end of the plunger is in alignment with the flange surrounding the first opening of the body; and the device is in the open position when the bottom end of the plunger is not in alignment with the flange surrounding the first opening of the body. 2. The device of claim 1, wherein the component for inhibiting rotation of the plunger within the bore during actuation of the device comprises a protruding member located on the outer wall of the plunger, and the first section of the body further comprises a receiving member located on the inner wall of first section of the body for receiving the protruding member, and inhibiting the rotation and promoting the linear movement of the plunger within the bore during rotation of the second section of the body during actuation of the device. 3. The device of claim 1, wherein the second section of the body comprises a protruding lip, and the first section of the body comprises a second groove for receiving the lip and permitting the rotation of the second section around the first section during actuation of the device. 4. The device of claim 1, wherein the bore is a central bore through the entire length of the body. 5. The device of claim 1, further comprising a cam located on the plunger that rides in a cam slot located on the second section of the body for limiting the length the plunger travels linearly within the bore during actuation of the device. 6. The device of claim 1, wherein the first portion of the plunger includes at least one additional opening in fluid communication with the fluid channel. 7. The device of claim 1, further comprising one or more seals arranged along a length or the bottom end of the plunger between the bottom end of the plunger and the first opening of the plunger, the one or more seals forming the fluid-resistant seal when the bottom end of the plunger and the flange are in alignment. 8. The device of claim 1, wherein the body is formed of a plastic selected from the group consisting of polyetherimides (PEI), polyetheretherketone (PEEK), polyetherketone (PEK), polysulphones, polyarylsulphones, polyalkoxysulphones, polyethersulphones, polyphenyleneoxide, polyphenylenesulphide and blends thereof. 9. The device of claim 1, wherein at least the steam sterilizable face is formed of material selected from the group consisting of polyetherimides (PEI), polyetheretherketone (PEEK), polyetherketone (PEK), polysulphones, polyarylsulphones, polyalkoxysulphones, polyethersulphones, polyphenyleneoxide, polyphenylenesulphide, ceramic, metal and combinations thereof. 10. The device of claim 1, wherein the plunger is formed of a material selected from the group consisting of polyetherimides (PEI), polyetheretherketone (PEEK), polyetherketone (PEK), polysulphones, polyarylsulphones, polyalkoxysulphones, polyethersulphones, polyphenyleneoxide, polyphenylenesulphide, ceramic metal and combinations thereof. 11. The device of claim 1, wherein the device is selected from the group consisting of a connector and a flow through valve. 12. The device of claim 1, further comprising an outer wall component to further secure the linear or gland seal to the first section of the body. 13. A process for the sterile transfer of a fluid, comprising: a) providing a fluid transfer device, comprising:a body comprising: a first section having a groove on a surface and a first end containing a first opening and a flange surrounding the first opening for attaching the body to a process component;a second section rotatably engaged with the first section and having a second end containing a second opening; anda bore located in the interior of the body connecting the first and second openings;a linearly movable plunger movable between a closed position corresponding to a closed position of the device and an open position corresponding to an open position of the device, the linearly movable plunger being contained within the bore and having, a groove,a first portion containing a first opening and a bottom end, wherein the bottom end being in alignment with the flange surrounding the first opening of the body forms a fluid-resistant seal and a steam sterilizable face,a second portion containing a second opening,a fluid channel located in the interior of the plunger connecting the first and second openings of the plunger, anda component for inhibiting rotation of the plunger within the bore during actuation of the device; anda linear or gland seal arranged along a length of the plunger between the first opening of the plunger and the second opening of the plunger, a first portion of the linear or gland seal being retained within the groove on the surface of the first section of the body and a second portion of the linear or gland seal being retained within the groove on the plunger in sealing contact with the plunger and an inner surface of the first section of the body,wherein the plunger is linearly movable between a closed position and an open position by rotating the second section of the body; the device is in the closed position when the bottom end of the plunger is in alignment with the flange surrounding the first opening of the body; and the device is in the open position when the bottom end of the plunger is not in alignment with the flange surrounding the first opening of the body;b) connecting the device to a first process component and sterilizing the first process component and the device when the device is in the closed position;c) attaching the first end of the body of the transfer device to a second process component when the device is in the closed position to form a liquid tight seal;d) steam sterilizing the second process component and the steam sterilizable face;e) opening the device by moving the plunger linearly in a first direction so as to allow for fluid communication between the second process component, the fluid channel within the plunger and the first process component; andf) closing the device by linearly moving the plunger in a direction opposite to the first direction to seal the fluid channel within the plunger and the first process component from the second process component. 14. The process of claim 13, wherein the bore of the transfer device is a central bore formed through the entire length of the body. 15. The process of claim 13, wherein the fluid is selected from the group consisting of liquids and gases. 16. The process of claim 13, wherein the device is formed of polyetherimides(PEI), polyetheretherketone (PEEK), polyetherketone (PEK), polyarylsulphones, polyalkoxysulphones, polyethersulphones, polyphenyleneoxide, polyphenylenesulphide and blends thereof. 17. The process of claim 13, wherein the device is capable of forming a sterile to sterile connection. 18. The process of claim 13, wherein the device is capable of forming a sterile to non-sterile connection. 19. The process of claim 13, wherein the transfer device and the first process component are sterilized by gamma radiation. 20. The process of claim 13, wherein the first process component is formed of a tube having a first end connected to the second end of the body and a bag attached to a second end of the tube. 21. The process of claim 13, wherein the first process component is formed of a tube having a first end connected to the second end of the body and an encapsulated filter attached to a second end of the tube. 22. The process of claim 13, wherein the second process component is a process pipe, fitting, or T-fitting. 23. A device for fluid transfer, comprising: a body comprising: a first section having a groove on a surface and a first end containing a first opening and a flange surrounding the first opening for attaching the body to a process component;a second section rotatably engaged with the first section and having a second end containing a second opening; anda bore located in the interior of the body connecting the first and second openings;a linearly movable plunger movable between a closed position corresponding to a closed position of the device and an open position corresponding to an open position of the device, the linearly movable plunger being contained within the bore and having: a groove,a first portion containing a first opening and a bottom end,a second portion containing a second opening,a fluid channel located in the interior of the plunger connecting the first and second openings of the plunger, anda component for inhibiting rotation of the plunger within the bore during actuation of the device;a non-rupturing seal, arranged along a length or the bottom end of the plunger between the bottom end of the plunger and the first opening of the plunger, that forms a fluid-resistant seal when the plunger is in the closed position, at least a portion of the non-rupturing seal and at least a portion of the flange forming a steam sterilizable face and a sterile barrier between the environment and at least a portion of the bore and the plunger when the plunger is in the closed position; anda linear or gland seal arranged along a length of the plunger between the first opening of the plunger and the second opening of the plunger, a first portion of the linear or gland seal being retained within the groove on the surface of the first section of the body and a second portion of the linear or gland seal being retained within the groove on the plunger in sealing contact with the plunger and an inner surface of the first section of the body,wherein the plunger is linearly movable between a closed position and an open position by rotating the second section of the body; the device is in the closed position when the bottom end of the plunger is in alignment with the flange surrounding the first opening of the body; and the device is in the open position when the bottom end of the plunger is not in alignment with the flange surrounding the first opening of the body. 24. The device of claim 23, further comprising an outer wall component to further secure the linear or gland seal to the first section of the body. 25. A fluid transfer device comprising: a body having a bore through at least a portion of its interior, the bore formed by a first section of the body rotatably engaged with a second section of the body, the first section of the body further including a groove on a surface and a connecting component for attaching the fluid transfer device to a process component;a linearly movable plunger contained within the bore, comprising: a groove,a bottom end, wherein the bottom end being in alignment with the connecting component forms a fluid-resistant seal and a steam sterilizable face,a fluid channel located in the interior of the plunger connecting a first opening in a first portion of the plunger to a second opening in a second portion of the plunger, anda component for inhibiting rotation of the plunger within the bore during actuation of the device; anda linear or gland seal arranged along a length of the plunger between the first opening of the plunger and the second opening of the plunger, a first portion of the linear or gland seal being retained within the groove on the surface of the first section of the body and a second portion of the linear or gland seal being retained within the groove on the plunger in sealing contact with the plunger and an inner surface of the first section of the body,wherein the plunger is linearly movable between a closed position corresponding to a closed position of the device and an open position corresponding to an open position of the device by rotating the second section of the body; the device is in the closed position when the bottom end of the plunger is in alignment with the connecting component; and the device is in the open position when the bottom end of the plunger is not in alignment with the connecting component.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.