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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0849414 (2010-08-03) |
등록번호 | US-8690874 (2014-04-08) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 442 |
A composition for the induction of bone growth is disclosed. The composition includes a substrate, bone growth protein, and sources of calcium and phosphate. The composition is acidic which promotes high activity of the bone growth protein. The calcium and phosphate sources can be provided as an aci
A composition for the induction of bone growth is disclosed. The composition includes a substrate, bone growth protein, and sources of calcium and phosphate. The composition is acidic which promotes high activity of the bone growth protein. The calcium and phosphate sources can be provided as an acidic calcium phosphate salt. Also disclosed are methods of the making the composition and methods of using it.
1. A bone graft composition comprising: particles of dehydrothermally cross-linked substrate including about 25 wt. % to about 40 wt. % bovine Type I dehydrothermally cross-linked dermal collagen and about 60 wt. % to about 75 wt. % calcium hydrogen phosphate, wherein the particles were prepared fro
1. A bone graft composition comprising: particles of dehydrothermally cross-linked substrate including about 25 wt. % to about 40 wt. % bovine Type I dehydrothermally cross-linked dermal collagen and about 60 wt. % to about 75 wt. % calcium hydrogen phosphate, wherein the particles were prepared from a lyophilized composition of collagen and calcium hydrogen phosphate; anda fluid selected from the group consisting of bone marrow aspirate, whole blood or combinations thereof,wherein the composition comprises about 2 to about 150 parts by weight of fluid. 2. The bone graft composition of claim 1 wherein the substrate comprises an acidic buffering potential when combined with the fluid. 3. The bone graft composition of claim 2 wherein the acidic buffering potential is between about pH 2 and about pH 5. 4. The bone graft composition of claim 1 wherein the substrate comprises calcium hydrogen phosphate in the form of particles which are about 125 microns to about 5000 microns in average size. 5. The bone graft composition of claim 1 wherein the lyophilized composition comprises a porosity of about 95% to about 98%. 6. The bone graft composition of claim 1 wherein the lyophilized composition is a sponge. 7. The bone graft composition of claim 1 wherein the average particle size is about 125 microns to about 300 microns. 8. The bone graft composition of claim 1 wherein the composition further comprises an acidic calcium phosphate other than calcium hydrogen phosphate. 9. The bone graft composition of claim 8 wherein the acidic calcium phosphate mineral comprises monocalcium phosphate. 10. The bone graft composition of claim 8 wherein the composition comprises about 2 parts by weight to about 15 parts by weight of an acidic calcium phosphate mineral other than calcium hydrogen phosphate. 11. The bone graft composition of claim 1 wherein the composition further comprises a second collagen other than bovine Type I dermal collagen. 12. The bone graft composition of claim 11 wherein the second collagen comprises a soluble collagen. 13. The bone graft composition of claim 11 wherein the composition comprises 1 part by weight to about 20 parts by weight of collagen other than bovine Type I dermal collagen. 14. The bone graft composition of claim 11 wherein the composition comprises about 85 parts by volume to about 95 parts by volume of the substrate and about 5 parts by volume to about 15 parts by volume of the second collagen. 15. The bone graft composition of claim 11 wherein the composition comprises about 3 parts by weight to about 10 parts by weight of the substrate; about 1 part by weight to about 20 parts by weight of collagen other than bovine Type I dermal collagen; and about 2 parts by weight to about 15 parts by weight of an acidic calcium phosphate mineral other than calcium hydrogen phosphate. 16. The bone graft composition of claim 1 wherein the composition is in the form of a putty. 17. The bone graft composition of claim 16, wherein a volume ratio of the fluid to a dry substrate volume is 0.6:1. 18. The bone graft composition of claim 16 wherein a volume ratio of the fluid to a dry substrate volume is 1.3:1. 19. The bone graft composition of claim 1 wherein the composition is in the form of a paste. 20. The bone graft composition of claim 1 wherein the fluid further comprises a fluid selected from the group consisting of platelet-rich-plasma, serum, saline, water, PBS, cell culture media or combinations thereof.
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