Chromatography cartridge and method for manufacturing a chromatography cartridge
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-015/22
G01N-030/60
출원번호
US-0694504
(2007-03-30)
등록번호
US-8696910
(2014-04-15)
발명자
/ 주소
DeMarco, Nicholas
출원인 / 주소
Agilent Technologies, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
A chromatography cartridge and method of manufacturing same. A chromatography cartridge of the present invention can include a tubular housing having an open end and an inner surface, and a plug. The plug can be positioned within the open end of the tubular housing and can have an outer circumferent
A chromatography cartridge and method of manufacturing same. A chromatography cartridge of the present invention can include a tubular housing having an open end and an inner surface, and a plug. The plug can be positioned within the open end of the tubular housing and can have an outer circumferential surface, a substantial portion of the outer circumferential surface being fused to the inner surface of the tubular housing. A method for manufacturing a chromatography cartridge can include coupling at least a portion of the outer surface of the plug to at least a portion of the inner surface of the tubular housing in response to rotating at least one of the plug and the tubular housing about the longitudinal axis with respect to the other of the plug and the tubular housing.
대표청구항▼
1. A method of manufacturing a chromatography column, the method comprising: providing an elongated tubular housing having a first end, a second end, an exterior surface and an interior surface, the first end integrally formed with the housing and including a port defining a fluid inlet, the interio
1. A method of manufacturing a chromatography column, the method comprising: providing an elongated tubular housing having a first end, a second end, an exterior surface and an interior surface, the first end integrally formed with the housing and including a port defining a fluid inlet, the interior surface defining an interior space;positioning a first frit adjacent the first end in the interior space;filling the interior space with chromatography medium between the first frit and a second frit positioned adjacent the second end in the interior space, the second frit including a first surface and a second surface opposite the first surface wherein at least a portion of the first surface is in contact with the chromatography medium; andspin-welding a cap to the tubular housing to close the second end until at least a portion of a bottom surface of the cap is in contact with the second surface of the second frit so that the cap positions the second frit to densely pack the chromatography medium and substantially prevents a liquid phase from channeling through the chromatography medium, the cap including a port defining a fluid outlet, the cap including an exterior surface and a plurality of radially extending ribs on the exterior surface. 2. The method of manufacturing a chromatography column of claim 1, wherein spin-welding the cap includes spin-welding a portion of the cap to the interior surface of the tubular housing. 3. The method of manufacturing a chromatography column of claim 1, wherein spin-welding the cap includes spin-welding a portion of the cap to the exterior surface of the tubular housing. 4. The method of manufacturing a chromatography column of claim 1, wherein spin-welding the cap includes spin-welding a first portion of the cap to the exterior surface of the tubular housing and a second portion of the cap to the interior surface of the tubular housing. 5. The method of manufacturing a chromatography column of claim 1, wherein the cap includes a shroud at least partially in contact with the exterior surface of the tubular housing. 6. The method of manufacturing a chromatography column of claim 5, wherein the shroud includes an interior surface, and further comprising spin-welding a portion of the interior surface of the shroud to the exterior surface of the tubular housing. 7. The method of manufacturing a chromatography column of claim 1, wherein the bottom surface of the cap is oriented substantially parallel to the second surface of the second frit. 8. A method of manufacturing a chromatography column, the method comprising: providing an elongated tubular housing having a first end, a second end, an exterior surface and an interior surface, the first end integrally formed with the housing and including a port defining a fluid outlet, the interior surface defining an interior space;positioning a first frit adjacent the first end in the interior space;filling the interior space with chromatography medium between the first frit and a second frit positioned adjacent the second end in the interior space, the second frit including a first surface and a second surface opposite the first surface wherein at least a portion of the first surface is in contact with the chromatography medium; andspin-welding a cap to the tubular housing to close the second end until at least a portion of a bottom surface of the cap is in contact with the second surface of the second frit so that the cap positions the second frit to densely pack the chromatography medium and substantially prevents a liquid phase from channeling through the chromatography medium, the cap including a port defining a fluid inlet, the cap including an exterior surface and a plurality of radially extending ribs on the exterior surface. 9. The method of manufacturing a chromatography column of claim 8, wherein spin-welding the cap includes spin-welding a portion of the cap to the interior surface of the tubular housing. 10. The method of manufacturing a chromatography column of claim 8, wherein spin-welding the cap includes spin-welding a portion of the cap to the exterior surface of the tubular housing. 11. The method of manufacturing a chromatography column of claim 8, wherein spin-welding the cap includes spin-welding a first portion of the cap to the exterior surface of the tubular housing and a second portion of the cap to the interior surface of the tubular housing. 12. The method of manufacturing a chromatography column of claim 8, wherein the cap includes a shroud at least partially in contact with the exterior surface of the tubular housing. 13. The method of manufacturing a chromatography column of claim 12, wherein the shroud includes an interior surface, and further comprising spin-welding a portion of the interior surface of the shroud to the exterior surface of the tubular housing. 14. The method of manufacturing a chromatography column of claim 8, wherein the bottom surface of the cap is oriented substantially parallel to the second surface of the second frit.
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