Osteochondral implant comprising osseous phase and chondral phase
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
C12N-011/02
C12N-011/08
C12N-011/06
C12N-011/04
G01N-033/544
G01N-033/545
G01N-033/549
C07K-017/02
C07K-017/08
C07K-017/06
C07K-017/04
출원번호
US-0778256
(2010-05-12)
등록번호
US-8697111
(2014-04-15)
발명자
/ 주소
Desai, Arpan
Sargeant, Timothy
Agawu, Atu
Stopek, Joshua
출원인 / 주소
Covidien LP
인용정보
피인용 횟수 :
0인용 특허 :
36
초록
An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold capable of reacting with the one or more pendant reactive functional groups of the first scaffold.
대표청구항▼
1. An osteochondral implant comprising: an osseous phase comprising a first scaffold comprising a first sponge comprising poly(lactic-co-glycolic acid) and having an outer surface containing one or more pendant reactive functional groups; anda chondral phase comprising a second scaffold comprising a
1. An osteochondral implant comprising: an osseous phase comprising a first scaffold comprising a first sponge comprising poly(lactic-co-glycolic acid) and having an outer surface containing one or more pendant reactive functional groups; anda chondral phase comprising a second scaffold comprising a second sponge comprising collagen and having in and on the sponge at least one dry hydrogel precursor containing one or more pendant complimentary reactive functional groups capable of forming a bond with the one or more pendant reactive functional groups of the first scaffold,wherein the first sponge further comprises bone growth factors and the second sponge further comprises cartilage growth factors. 2. The osteochondral implant according to claim 1, wherein the one or more pendant reactive functional groups comprise an electrophilic group. 3. The osteochondral implant according to claim 2, wherein the electrophilic group is selected from the group consisting of N-hydroxysuccinimides, sulfosuccinimides, carbonyldiimidazole, sulfonyl chloride, aryl halides, sulfosuccinimidyl esters, N-hydroxysuccinimidyl esters, succinimidyl esters, isocyanates, thiocyanates, carbodiimides, benzotriazole carbonates, epoxides, aldehydes, maleimides, imidoesters, and combinations thereof 4. The osteochondral implant according to claim 1, wherein the one or more pendant reactive functional groups comprise a nucleophilic group. 5. The osteochondral implant according to claim 4, wherein the nucleophilic group is selected from the group consisting of —NH2, —SH, —OH, —PH2, —CO—NH—NH2 and combinations thereof. 6. The osteochondral implant according to claim 4, wherein the nucleophilic group is an amine group. 7. The osteochondral implant according to claim 4, wherein the one or more complimentary reactive functional groups comprise an electrophilic group. 8. The osteochondral implant according to claim 7, wherein the electrophilic group is selected from the group consisting of N-hydroxysuccinimides, sulfosuccinimides, carbonyldiimidazole, sulfonyl chloride, aryl halides, sulfosuccinimidyl esters, N-hydroxysuccinimidyl esters, succinimidyl esters, isocyanates, thiocyanates, carbodiimides, benzotriazole carbonates, epoxides, aldehydes, maleimides, imidoesters, and combinations thereof. 9. The osteochondral implant according to claim 2, wherein the one or more complimentary reactive functional groups comprise a nucleophilic group. 10. The osteochondral implant according to claim 9, wherein the nucleophilic group is selected from the group consisting of —NH2, —SH, —OH, —PH2, —CO—NH—NH2 and combinations thereof. 11. The osteochondral implant according to claim 9, wherein the nucleophilic group is an amine group. 12. The osteochondral implant according to claim 1, further comprising at least one bioactive agent. 13. The osteochondral implant according to claim 12, wherein the bioactive agent is selected from the group consisting of amino acids, peptides, antibodies, enzymes, drugs, bone growth factors, bone morphogenic proteins, and combinations thereof.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (36)
Sawhney,Amarpreet S., Adhesion barriers applicable by minimally invasive surgery and methods of use thereof.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Implants coated with collagen-polymer conjugates.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Seidel Hartmut (Hochrad 19 2000 Hamburg 52 DEX) Polzhofer Kurt (Bellmannstr. 8 2000 Hamburg 52 DEX), Self-curing composition based upon polymethylmethacrylate and process for manufacturing said self-curing composition.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.