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A system, method and device for immobilizing an imager in-vivo and/or focusing images on the imager reflected from an in-vivo site to be monitored with for example a moveable or otherwise adjustable focusing mechanism. The imaging sensor may for example be positioned on an acute angle to an in-vivo

A system, method and device for immobilizing an imager in-vivo and/or focusing images on the imager reflected from an in-vivo site to be monitored with for example a moveable or otherwise adjustable focusing mechanism. The imaging sensor may for example be positioned on an acute angle to an in-vivo surface to which the device is immobilized so that the device may for example image an in-vivo area that is opposed to such device. Sensors in addition to or other than an imaging sensor may be used.

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1. An autonomous in-vivo device for monitoring a site in-vivo, the in-vivo device comprising: a housing adapted to be mountable to an in-vivo surface for being immobilized in-vivo, the housing comprising:a dome-shaped optical window;an optical system positioned behind the optical window, the optical

1. An autonomous in-vivo device for monitoring a site in-vivo, the in-vivo device comprising: a housing adapted to be mountable to an in-vivo surface for being immobilized in-vivo, the housing comprising:a dome-shaped optical window;an optical system positioned behind the optical window, the optical system comprising a focusing lens;an image sensor positioned behind the optical window and within the housing, wherein said image sensor is positioned to face in a direction at an acute angle relative to a side of the housing which is mounted, wherein the angle is adjustable; anda moveable focusing mechanism, comprising a focusing lever positioned on the housing, allowing the distance of the focusing lens relative to the image sensor to be adjusted by moving the image sensor by a shaft, wherein the focusing lens is located at a fixed distance from the optical window. 2. The in-vivo device as in claim 1, wherein said housing further comprises rotatable clasps. 3. The in-vivo device as in claim 1, comprising an illumination source. 4. The in-vivo device as in claim 3, comprising a controller to control illumination. 5. The in-vivo device as in claim 1, comprising a controller to control a frame rate of said imaging device. 6. The in-vivo device as in claim 1, wherein said housing further comprises a vacuum pad configured to immobilize said housing to an endo-lumenal surface. 7. The in-vivo device as in claim 1, wherein said housing is configured to accept a suture to immobilize said housing to an endo-lumenal surface. 8. The in-vivo device as in claim 1, further comprising a base to which the imaging sensor is attached, the base comprising an edge moveably joined to a thread, wherein the edge moves within a track. 9. An autonomous in-vivo device configured for passing through a body lumen, the device comprising: a housing adapted to be mountable to an in-vivo surface for being temporarily immobilized in-vivo, the housing comprising: a dome-shaped optical window; an optical system comprising a focusing lens behind the optical window; an image sensor positioned behind the optical window and within the housing, wherein said image sensor is positioned to face in a direction at an acute angle relative to a side of the housing which is mounted, wherein the angle is adjustable; and a moveable focusing mechanism, comprising a shaft and focusing screw positioned on the housing, allowing the distance of the focusing lens relative to the image sensor to be adjusted by moving the image sensor by a shaft, wherein the focusing lens is located at a fixed distance from the optical window. 10. The autonomous device as in claim 9, wherein said imaging device is positioned at an acute angle relative to a surface of a body lumen upon which said housing is immobilized. 11. The autonomous device as in claim 9, comprising means for temporarily immobilizing said housing in vivo. 12. An autonomous in-vivo device for monitoring a site in-vivo, the in-vivo device comprising: a housing adapted to be mountable to an in-vivo surface for being immobilized in-vivo, the housing comprising: a dome-shaped optical window; an optical system comprising a focusing lens behind the optical window; an image sensor positioned behind the optical window and within the housing, wherein said image sensor is positioned to face in a direction at an acute angle relative to a side of the housing which is mounted, wherein the angle is adjustable by a moveable focusing mechanism positioned on the housing; and a base to which the imaging sensor is attached, the base comprising an edge moveably joined to a thread, allowing an end of the base to move within a track, wherein the focusing lens is located at a fixed distance from the optical window.