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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0914542 (2013-06-10) |
등록번호 | US-8706180 (2014-04-22) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 377 |
An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of a
An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.
1. An in vivo glucose sensor, comprising: a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface;a working electrode disposed on the distal region of the first surface of the subs
1. An in vivo glucose sensor, comprising: a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface;a working electrode disposed on the distal region of the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface;a counter electrode disposed on the distal region of the second surface of the substrate;a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the work electrode, and a second one of plurality of conductive contacts is in electrical communication with the counter electrode;at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts;a sensing layer proximate to the working electrode; anda mass transport limiting layer proximate to the working electrode; wherein a flexibility of sensor is varied along a continuum of the substrate 2. the glucose sensor of claim 1, wherein the varied flexibility of sensor is based at least in on a composition substrate. 3. The glucose sensor of claim 1, wherein the varied flexibility of the sensor is based at least in part on a thickness of the substrate. 4. The glucose sensor of claim 1, wherein the varied flexibility of the sensor is based at least in part on a composition and a thickness of the substrate. 5. The glucose sensor of claim 1, wherein the sensor is a planar sensor. 6. The glucose sensor of claim 1, further including a reference electrode disposed on the distal region on the first surface of the substrate and configured to be positioned in fluid contact with the interstitial fluid under the skin surface, and a third one of the plurality of conductive contacts is in electrical communication with the reference electrode. 7. The glucose sensor of claim 1, wherein the working electrode comprises a glucose-responsive enzyme and a mediator, wherein at least one of the glucose-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the glucose-responsive enzyme and the mediator is crosslinked with the polymer. 8. An in vivo glucose sensor, comprising: a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface;a working electrode disposed on the distal region on the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface;a counter electrode disposed on the distal region on the second surface of the substrate;a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the working electrode, and a second one of the plurality of conductive contacts is in electrical communication with the counter electrode;at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts; anda sensing layer proximate to the working electrode; wherein a length of the sensor is between 0.3 cm and 5 cm, and a flexibility of the sensor is varied along a continuum of the substrate. 9. The glucose sensor of claim 8, further comprising a subcutaneous portion, wherein the length of the subcutaneous portion is between 0.25 cm and 2 cm. 10. The glucose sensor of claim 8, further comprising a subcutaneous portion, wherein the length of the subcutaneous portion is 0.25 cm or less. 11. The glucose sensor of claim 8, wherein the varied flexibility of the sensor is based at least in part on a composition of the substrate. 12. The glucose sensor of claim 8, wherein the varied flexibility of the sensor is based at least in part on a thickness of the substrate. 13. The glucose sensor of claim 8, wherein the varied flexibility of the sensor is based at least in part on a composition and a thickness of the substrate. 14. The glucose sensor of claim 8, wherein the sensor is a planar sensor 15. The glucose sensor of claim 8, further including a reference electrode disposed on the distal region on the first surface of the substrate and configured to be positioned in fluid contact with the interstitial fluid under the skin surface, and a third one of the plurality of conductive contacts is in electrical communication with the reference electrode. 16. The glucose sensor of claim 8, wherein the working electrode comprises a glucose-responsive enzyme and a mediator, wherein at least one of the glucose-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the glucose-responsive enzyme and the mediator is crosslinked with the polymer. 17. An in vivo glucose sensor, comprising: a substrate having a distal region for partial implantation through a skin surface and a proximal region, the substrate including at least a first surface and a second surface;a working electrode disposed on the distal region on the first surface of the substrate;a counter electrode disposed on the distal region on the second surface of the substrate;a plurality of conductive contacts disposed on the proximal region of the substrate and on the first surface of the substrate, wherein a first one of the plurality of conductive contacts is in electrical communication with the working electrode, and a second one of the plurality of conductive contacts is in electrical communication with the counter electrode;at least one via formed through the substrate that electrically connects the counter electrode to the second one of the plurality of conductive contacts; anda sensing layer proximate to the working electrode; wherein a flexibility of the sensor is varied along a continuum of the substrate. 18. The glucose sensor of claim 17, wherein the substrate has a thickness of 100 μm to 300 μm. 19. The glucose sensor of claim 17, wherein the varied flexibility of the sensor is based at least in part on a composition of the substrate. 20. The glucose sensor of claim 17, wherein the varied flexibility of the sensor is based at least in part on a thickness of the substrate. 21. The glucose sensor of claim 17, wherein the varied flexibility of the sensor is based at least in part on a composition and a thickness of the substrate. 22. The glucose sensor of claim 17, wherein the sensor is a planar sensor. 23. The glucose sensor of claim 17, further including a reference electrode disposed on the distal region on the first surface of the substrate and configured to be positioned in fluid contact with interstitial fluid under the skin surface, and a third one of the plurality of conductive contacts is in electrical communication with the reference electrode. 24. The glucose sensor of claim 17, wherein the at least one via includes a plurality of vias formed through the substrate, each one of the plurality of vias electrically connecting the counter electrode to the second one of the plurality of conductive contacts. 25. The glucose sensor of claim 17, wherein the working electrode comprises a glucose-responsive enzyme and a mediator, wherein at least one of the glucose-responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the glucose-responsive enzyme and the mediator is crosslinked with the polymer.
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