[미국특허]
hUTC as therapy for Alzheimer's disease
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-048/00
A61K-035/50
C12N-005/00
A61K-035/48
C12N-005/073
C12N-005/10
C12N-015/63
출원번호
US-0748170
(2010-03-26)
등록번호
US-8722034
(2014-05-13)
발명자
/ 주소
Kihm, Anthony J.
Gosiewska, Anna
출원인 / 주소
DePuy Synthes Products LLC
대리인 / 주소
Johnson, Philip J.
인용정보
피인용 횟수 :
3인용 특허 :
83
초록▼
Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from
Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells, such as cell derivatives. Some embodiments are to methods for treatment comprising hUTC. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
대표청구항▼
1. A method of reducing amyloid plaque formation or diminishing amyloid plaques in a patient, said method comprising administering to the subject a composition comprising a population of isolated human umbilical cord-derived cells such that amyloid plaque formation is reduced or diminished, wherein
1. A method of reducing amyloid plaque formation or diminishing amyloid plaques in a patient, said method comprising administering to the subject a composition comprising a population of isolated human umbilical cord-derived cells such that amyloid plaque formation is reduced or diminished, wherein the isolated human umbilical cord-derived cells are obtained from human umbilical cord tissue substantially free of blood, wherein the isolated cells self-renew and expand in culture and do not express CD117. 2. The method of claim 1, wherein the isolated human umbilical cord-derived cells are administered locally to a neurotic plaque site. 3. The method of claim 1, wherein the isolated human umbilical cord-derived cells are administered to cerebral spinal fluid. 4. The method of claim 1, said method further comprising pre-treating the population of human umbilical cord-derived cells with electrical stimulation. 5. The method of claim 1, said composition further comprising pharmaceutically acceptable carriers and/or diluents selected from the group consisting of: saline, aqueous buffer solutions, solvents, artificial cerebral spinal fluid, dispersion media composition and a mix thereof. 6. The method of claim 1, wherein said human umbilical cord-derived cells comprise cells that are genetically modified to produce therapeutically useful gene products or to produce agents to enhance neural cell survival, differentiation or phagocytic activity of the cells. 7. The method of claim 1, wherein said human umbilical cord-derived cells comprise cells that are genetically modified to produce therapeutically useful gene products or to produce agents to enhance degradation of amyloid plaques, or prevent formation of amyloid plaques. 8. The method of claim 1, wherein the cells express each of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, and HLA-A,B,C. 9. The method of claim 1, wherein the calls do not express any of CD31, CD34, CD45, CD141, and LHA-DR,DP,DQ. 10. The method of claim 1, wherein the patient has symptoms of Alzheimer's disease.
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