[특허]Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

Liveleaf, Inc.

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Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/44
미국특허분류(USC)	424/094.4;
출원번호	US-0135124 (2011-06-24)
등록번호	US-8722040 (2014-05-13)
발명자 / 주소	Huang, Alexander L. Wu, Gin
출원인 / 주소	Liveleaf, Inc.
대리인 / 주소	Boyer, Brian S.
인용정보	피인용 횟수 : 10 인용 특허 : 47

초록

The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.

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1. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a flavanol. 2. A pharmaceutical formulation comprising the system of claim 1 and a pharmaceutically acceptable excipient. 3. The system of claim 1, wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 4. The system of claim 1, wherein the extract comprises a catechin. 5. The system of claim 1, wherein the extract comprises gallic acid, epigallic acid, or a combination thereof. 6. The system of claim 1, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 7. A kit for generating the binding system of claim 1, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 8. A kit comprising the binding system of claim 1, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 9. A binding system, comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol. 10. The system of claim 9 comprising a catechin. 11. The system of claim 9 comprising gallic acid, epigallic acid, or a combination thereof. 12. A binding system, comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol. 13. The system of claim 12 comprising a catechin. 14. The system of claim 12 comprising gallic acid, epigallic acid, or a combination thereof. 15. A binding system, comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol. 16. The system of claim 15 comprising a catechin. 17. The system of claim 15 comprising gallic acid, epigallic acid, or a combination thereof. 18. The system of claim 15 comprising an extract of pomegranate. 19. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a catechin. 20. A pharmaceutical formulation comprising the system of claim 19 and a pharmaceutically acceptable excipient. 21. The system of claim 19, wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 22. The system of claim 19, wherein the extract comprises a flavanol. 23. The system of claim 19, wherein the extract comprises gallic acid, epigallic acid, or a combination thereof. 24. The system of claim 19, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 25. A kit for generating the binding system of claim 19, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 26. A kit comprising the binding system of claim 19, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 27. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a gallic acid, epigallic acid, or a combination thereof. 28. A pharmaceutical formulation comprising the system of claim 27 and a pharmaceutically acceptable excipient. 29. The system of claim 27, wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 30. The system of claim 27, wherein the extract comprises a flavanol. 31. The system of claim 27, wherein the extract comprises a catechin. 32. The system of claim 27, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 33. A kit for generating the binding system of claim 27, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 34. A kit comprising the binding system of claim 27, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 35. A binding system, comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechin. 36. The system of claim 35 comprising a flavanol. 37. The system of claim 35 comprising gallic acid, epigallic acid, or a combination thereof. 38. A kit for generating the binding system of claim 35, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 39. A kit comprising the binding system of claim 35, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 40. A binding system, comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereof. 41. The system of claim 40 comprising a flavanol. 42. The system of claim 40 comprising a catechin. 43. A kit for generating the binding system of claim 40, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 44. A kit comprising the binding system of claim 40, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 45. A binding system, comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechin. 46. The system of claim 45 comprising a flavanol. 47. The system of claim 45 comprising gallic acid, epigallic acid, or a combination thereof. 48. A kit for generating the binding system of claim 45, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 49. A kit comprising the binding system of claim 45, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 50. A binding system, comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereof. 51. The system of claim 50 comprising a flavanol. 52. The system of claim 50 comprising a catechin. 53. A kit for generating the binding system of claim 50, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 54. A kit comprising the binding system of claim 50, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 55. A binding system, comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechin. 56. The system of claim 55 comprising a flavanol. 57. The system of claim 55 comprising gallic acid, epigallic acid, or a combination thereof. 58. A kit for generating the binding system of claim 55, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 59. A kit comprising the binding system of claim 55, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 60. A binding system, comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereof. 61. The system of claim 60 comprising a flavanol. 62. The system of claim 60 comprising a catechin. 63. The system of claim 60 comprising an extract of pomegranate. 64. A binding system, comprising a flavanol; and,hydrogen peroxide;wherein the flavanol and the peroxide are combined to form a binding system. 65. A binding system, comprising a catechin; and,hydrogen peroxide;wherein the catechin and the peroxide are combined to form a binding system. 66. A binding system, comprising a gallic acid, epigallic acid, or a combination thereof; and,hydrogen peroxide;wherein the gallic acid, epigallic acid, or a combination thereof and the peroxide are combined to form a binding system.

이 특허에 인용된 특허 (47)

이 특허를 인용한 특허 피인용횟수: 10

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Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

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Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites

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