[특허]Neural tourniquet

[미국특허] Neural tourniquet 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/4747 A61K-031/4439 A61K-031/165
출원번호	US-0088683 (2005-03-24)
등록번호	US-8729129 (2014-05-20)
발명자 / 주소	Tracey, Kevin J. Amella, Carol Ann Czura, Christopher
출원인 / 주소	The Feinstein Institute for Medical Research
대리인 / 주소	Shay Glenn LLP
인용정보	피인용 횟수 : 13 인용 특허 : 217

초록 ▼

Disclosed is a method of reducing bleed time in a subject by activation of the cholinergic anti-inflammatory pathway in said subject. The cholinergic anti-inflammatory pathway can be activated by direct or indirect stimulation of the vagus nerve. The cholinergic anti-inflammatory pathway can also be

대표청구항 ▼

1. A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a signal current of less than 10 mA; and reducing bleed time of the bleeding by at least 20%. 2. The method of claim 1 wherein the subject is a human. 3. The method of claim 1 wherein the cholinergic anti-inflammatory pathway is activated by stimulating the vagus nerve in the brain. 4. The method of claim 1 wherein the vagus nerve is indirectly stimulated. 5. The method of claim 4 wherein the vagus nerve is indirectly stimulated with a transdermal or trans-esophageal device. 6. The method of claim 1 wherein the vagus nerve is directly stimulated. 7. The method of claim 6 wherein the vagus nerve is stimulated electrically. 8. The method of claim 6 wherein the efferent vagus nerve is stimulated. 9. The method of claim 8 wherein the efferent vagus nerve is stimulated electrically. 10. The method of claim 6 wherein the vagus nerve is directly stimulated with an implanted device. 11. The method of claim 1 wherein the subject suffers from a condition of hemophilia. 12. The method of claim 1 wherein the subject is suffering from a clotting disorder other than hemophilia. 13. The method of claim 1 wherein the subject is suffering bleeding caused by a wound. 14. The method of claim 1 wherein the subject is undergoing surgery. 15. A method of reducing bleed time in a subject expected to suffer bleeding during a surgical procedure, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a signal current of less than 10 mA, wherein the cholinergic anti-inflammatory pathway is stimulated prior to the surgical procedure; performing the surgical procedure; and reducing bleeding that resulted from the surgical procedure by at least 20%. 16. A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve with a constant voltage of between about 0.01V to 10V; and reducing bleed time of the bleeding by at least 20%. 17. The method of claim 16 wherein the cholinergic anti-inflammatory pathway is activated by stimulating the vagus nerve with a constant voltage of between about 0.01V to 1V. 18. The method of claim 16 wherein the cholinergic anti-inflammatory pathway is activated by stimulating the vagus nerve with a constant voltage of between about 0.01V to 0.1V. 19. The method of claim 16wherein the cholinergic anti-inflammatory pathway is activated by stimulating the vagus nerve with a constant voltage of between about 0.01V to 0.05V. 20. A method of reducing bleed time in a subject suffering bleeding, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve without decreasing the heart rate of the subject; and reducing bleed time of the bleeding by at least 20%. 21. A method of reducing bleed time in a subject in need of such treatment, the method comprising activating the cholinergic anti-inflammatory pathway by stimulating the vagus nerve; and reducing bleed time of the bleeding by at least 20%, wherein the subject is suffering bleeding caused by a wound. 22. The method of claim 1 wherein the activating includes stimulating for about 20 minutes or less. 23. The method of claim 1 wherein the activating includes stimulating for about 1 to about 120 seconds. 24. The method of claim 1, wherein the bleed time is reduced by at least 70% over non-treated controls.

이 특허에 인용된 특허 (217) 인용/피인용 타임라인 분석

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Neural tourniquet 원문보기

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