[특허]Compositions and methods for therapeutic delivery with frozen particles

The Invention Science Fund I, LLC

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Compositions and methods for therapeutic delivery with frozen particles

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G06F-019/00 A61M-005/30 A61K-009/14 A61M-005/00
미국특허분류(USC)	702/019; 604/065; 604/068
출원번호	US-0290691 (2008-10-31)
등록번호	US-8731841 (2014-05-20)
발명자 / 주소	Boyden, Edward S. Hyde, Roderick A. Leuthardt, Eric C. Myhrvold, Nathan P. Sweeney, Elizabeth A. Wood, Jr., Lowell L.
출원인 / 주소	The Invention Science Fund I, LLC
인용정보	피인용 횟수 : 0 인용 특허 : 171

초록

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

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1. A system comprising: at least one computing device;at least one computer program, configured with a computer-readable medium, for use with at least one computer system and wherein the computer program includes a plurality of instructions that when executed on the computing device cause the computing device to direct a pre-determined patterned delivery of a plurality of frozen particle therapeutic compositions to at least one biological tissue of at least one subject by a remote controlled device, the plurality of frozen particle therapeutic compositions including at least two sub-sets of frozen particles that include different therapeutic agents and at least one tracer agent; and compare information related to the delivery with information regarding at least one clinical outcome following receipt by the at least one subject; andat least one imaging device configured to measure the at least one tracer agent and provide real-time feedback control of the plurality of frozen particle therapeutic compositions administered to the at least one subject. 2. The system of claim 1, wherein the information related to the delivery includes information regarding amount of the plurality of therapeutic compositions or identity of at least one therapeutic agent administered to at least one biological tissue of at least one subject. 3. The system of claim 1, wherein the information related to the delivery includes information regarding at least one dimension of biological tissue penetration. 4. The system of claim 3, wherein the information regarding at least one dimension of biological tissue penetration includes information regarding at least one of depth, width, or breadth of administration of the plurality of frozen particle therapeutic compositions to at least one biological tissue of at least one subject. 5. The system of claim 1, wherein the computing device is configured to communicate with at least one printing device, at least one imaging device, or at least one input device. 6. The system of claim 1, wherein the information related to delivery includes information regarding two or more subjects with one or more common attributes. 7. The system of claim 1, wherein the information related to delivery includes information regarding at least one cellular or tissue source. 8. The system of claim 7, wherein the information regarding at least one cellular or tissue source includes information regarding at least one abnormal cellular or tissue source. 9. The system of claim 7, wherein information regarding the at least one cellular or tissue source includes information regarding at least one type of cell or tissue. 10. The system of claim 1, wherein at least one frozen particle therapeutic composition of the plurality includes at least one of nitrogen, carbon dioxide, hydrogen oxide, helium, neon, xenon, krypton, air, oxygen, chlorine, oxygen, air, bromine, argon, polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether. 11. The system of claim 1, wherein the frozen particles of the plurality have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween. 12. The system of claim 1, wherein at least one sub-set of the plurality of frozen particle therapeutic compositions includes one or more reinforcement agents. 13. The system of claim 1, wherein the at least one frozen particle therapeutic composition includes one or more explosive materials. 14. The system of claim 1, wherein the receipt by the at least one subject of at least one frozen particle therapeutic composition is pursuant to at least one clinical trial. 15. The system of claim 1, further including determining at least one correlation before the administration of the plurality of frozen particle therapeutic compositions. 16. The system of claim 1, further including creating at least one inclusion criterion and at least one exclusion criterion for a clinical trial involving the delivery of the plurality of frozen particle therapeutic compositions. 17. The system of claim 1, further including suggesting the inclusion of one or more of the at least one subject in at least one clinical trial. 18. The system of claim 1, further including suggesting the exclusion of one or more of the at least one subject in at least one clinical trial. 19. The system of claim 1, further including using one or more of the at least one comparison to predict at least one clinical outcome regarding at least one second subject. 20. The system of claim 19, wherein the at least one second subject has not received the plurality of frozen particle therapeutic compositions. 21. The system of claim 19, wherein using one or more of the at least one comparison further includes predicting at least one clinical outcome involving the at least one second subject, wherein the at least one second subject is a plurality of people; and segregating subject identifiers associated with the plurality of people in reference to the predicted at least one clinical outcome. 22. The system of claim 19, wherein using one or more of the at least one comparison includes the at least one second subject is a plurality of people; and determining the eligibility of the at least one second subject for the at least one clinical trial. 23. A system, comprising: at least one computing device;at least one computer program, configured with a computer-readable medium, for use with at least one computer system and wherein the computer program includes a plurality of instructions that when executed on the computing device cause the computing device to direct a pre-determined patterned delivery of a plurality of frozen particle therapeutic compositions to at least one biological tissue of at least one subject by a remote controlled device, the plurality of frozen particle therapeutic compositions including at least two sub-sets of frozen particles that include different therapeutic agents and at least one tracer agent, and compare information related to the delivery, and information regarding the plurality of frozen particle therapeutic compositions;one or more instructions for applying one or more comparisons to the information related to the delivery to a plurality of people;detect the at least one tracer agent, andprovide real-time feedback control of the amount of the plurality of frozen particle therapeutic compositions administered to the at least one subject. 24. The system of claim 23, further including one or more instructions for segregating subject identifiers associated with the plurality of people in reference to at least one of the one or more applied comparisons. 25. The system of claim 23, wherein the information related to the delivery includes information regarding the amount of therapeutic composition or therapeutic agent administered to at least one biological tissue of at least one subject. 26. The system of claim 23, wherein the information related to the delivery includes information regarding at least one dimension of biological tissue penetration. 27. The system of claim 26, wherein the information regarding at least one dimension of biological tissue penetration includes information relating to at least one of depth, width, or breadth of administration by a pellet gun of the at least one frozen particle therapeutic composition to at least one biological tissue of at least one subject. 28. The system of claim 23, further including one or more instructions for segregating individual identifiers associated with the plurality of people in reference to at least one characteristic shared by two or more subjects in the plurality of people. 29. A system, comprising: at least one computing device;at least one computer program, configured with a computer-readable medium, for use with at least one computer system and wherein the computer program includes a plurality of instructions that when executed on the at least one computing device cause the computing device to direct a pre-determined patterned delivery of a plurality of frozen particle therapeutic compositions to at least one biological tissue of at least one subject by a remote controlled device, the plurality of frozen particle therapeutic compositions including at least two sub-sets of frozen particles that include different therapeutic agents and at least one tracer agent; and compare information relating to delivery, and information regarding at least one frozen particle therapeutic composition of the plurality;one or more instructions for applying one or more comparisons to the information related to delivery to a plurality of people;one or more instructions for determining from the comparison at least one biological change following administration of one or more frozen particle therapeutic compositions of the plurality to the subject; andat least one imaging device configured to measure the at least one tracer agent and provide real-time feedback control of the amount of the at least one frozen particle therapeutic composition administered to the at least one subject. 30. The system of claim 1, wherein the tracer agent includes at least one of an electronic identification device, radioactive element, luminescent substance, fluorescent substance, phosphorescent substance, quantum dot, or magnetic particle.

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