IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0034569
(2011-02-24)
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등록번호 |
US-8733342
(2014-05-27)
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발명자
/ 주소 |
- Giroux, Marc
- DeGroodt, William A.
- Pearce, Joseph R.
- Kamp, Robert W.
- Rinne, Finn O.
- Leung, Paul C.
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출원인 / 주소 |
|
대리인 / 주소 |
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인용정보 |
피인용 횟수 :
6 인용 특허 :
89 |
초록
▼
Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter
Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.
대표청구항
▼
1. An aerosol generating and delivery device for delivering an atomized liquid, comprising: a liquid feed tube having a liquid feed channel with an inlet aperture, a liquid feed channel exit orifice, an end-wall face and a sidewall, wherein the end wall face is between the liquid feed channel exit o
1. An aerosol generating and delivery device for delivering an atomized liquid, comprising: a liquid feed tube having a liquid feed channel with an inlet aperture, a liquid feed channel exit orifice, an end-wall face and a sidewall, wherein the end wall face is between the liquid feed channel exit orifice and the perimeter of the liquid feed tube and is normal or substantially normal to a diverting portion of the sidewall of the liquid feed tube; anda compressed fluid feed channel having a compressed fluid exit orifice, the compressed fluid exit orifice being spaced from the diverting portion of the sidewall, the compressed fluid exit orifice being configured to direct a stream of compressed fluid toward the diverting portion of the sidewall, the diverting portion of the sidewall being configured to disrupt a portion of the stream of compressed fluid, the disrupted portion of the stream of compressed fluid being configured to atomize the liquid from the liquid feed channel exit orifice. 2. The device of claim 1, comprising: a reservoir configured to hold a liquid;a liquid supply member comprising the liquid feed tube having the sidewall with the diverting portion and comprising the liquid feed channel, the liquid feed channel inlet aperture in communication with the reservoir and the liquid feed channel exit orifice, the liquid feed channel being configured to draw liquid from the reservoir and transport it to the liquid feed channel exit orifice for aerosolization therefrom by a compressed fluid; anda compressed fluid supply member comprising the compressed fluid feed channel having the compressed fluid exit orifice, the diverting portion being located between the liquid feed channel exit orifice and the compressed fluid exit orifice, the compressed fluid feed channel being configured to receive a compressed fluid and conduct a portion of the compressed fluid through the compressed fluid exit orifice and into engagement with the diverting portion of the liquid supply member, the portion of the compressed fluid engaging the diverting portion being diverted by the diverting portion before aerosolizing the liquid from the liquid feed channel exit orifice. 3. The device of claim 2, wherein the portion of the compressed fluid conducted through the compressed fluid exit orifice exits the orifice along a projected longitudinal axis “F,” the liquid feed channel has a projected longitudinal axis “L,” and the projected longitudinal axis “F” intersects the projected longitudinal axis “L.” 4. The device of claim 1, wherein the compressed fluid channel and the diverting portion are configured such that a second portion of the compressed fluid conducted through the compressed fluid exit orifice does not engage the diverting portion of the liquid supply member. 5. The device of claim 1, wherein the diverting portion has a surface, the portion of the compressed fluid engaging the diverting portion engages the surface of the diverting portion, and the surface is configured to divert the portion of the compressed fluid engaging it non-uniformly. 6. The device of claim 1, wherein the liquid feed tube comprises a tube section, the liquid feed channel comprises a first portion disposed inside the tube section, the liquid feed channel exit orifice is formed in the tube section, and the tube section comprises an outside surface, and the diverting portion comprises a portion of the outside surface of the tube section located between the liquid feed channel exit orifice and the compressed fluid exit orifice. 7. The device of claim 1, wherein the liquid feed channel comprises the inlet aperture, the liquid feed channel exit orifice, and the end-wall face perimeter having an outside diameter disposed about the liquid feed channel exit orifice, the liquid feed channel defining a projected axis L; wherein the liquid feed channel exit orifice is separated by a distance of at least H from the compressed fluid exit orifice, H being measured along a projected longitudinal axis F that is normal to a plane P defined by the compressed fluid exit orifice,H is equal to or greater than ¼ times the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid exit orifice;the projected longitudinal axis L intersects the projected longitudinal axis F at an angle, defining an intersection plane I; and whereinat the distance H along projected longitudinal axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected longitudinal axis F, S being equal to or less than 2 times the inner diameter D1 of the compressed fluid feed channel. 8. The device of claim 1, comprising: a reservoir configured to hold the liquid;a liquid supply member comprising the liquid feed channel comprising: a first portion with a first diameter and the liquid feed channel exit orifice; anda second portion with a second diameter and the liquid feed channel inlet aperture in communication with the reservoir, the first portion diameter being smaller than the second portion diameter, the liquid feed channel being configured to draw the liquid from the reservoir into the inlet aperture of the second portion and transport it to the liquid feed channel exit orifice of the first portion for aerosolization therefrom by a compressed fluid; anda compressed fluid supply member comprising the compressed fluid channel and the compressed fluid exit orifice, configured to direct a compressed fluid flow passed the exit orifice of the first portion of the compressed fluid feed channel to provide for aerosolizing the liquid therefrom. 9. The device of claim 1, comprising: a housing having a wall defining an atomization chamber in which the liquid is atomizable, and comprising holding means suitable for holding the liquid to be atomized; andatomization means comprising the compressed fluid feed channel having a length and inner diameter, and the compressed fluid exit orifice at a first end thereof in fluid communication with the atomization chamber and defining a compressed fluid exit orifice plane P, the compressed fluid feed channel at a second end in fluid communication with a compressed fluid source and defining a projectable compressed fluid feed channel axis F, the atomization means further comprising the liquid feed channel having a length, inner diameter and channel wall, and at a first liquid feed channel end having the liquid feed channel end-wall face perimeter having an outside diameter disposed about the liquid feed channel orifice in fluid communication with the atomization chamber, the liquid feed channel at a second end in communication with the liquid holding means, the liquid feed channel defining a projectable longitudinal liquid feed channel axis L; whereinthe channel end wall face and the liquid feed channel exit orifice are separated by a distance of at least H from a primary orifice plane P, H being measured along the longitudinal axis F and H being equal to or greater than ¼ times the inner diameter D1 of the compressed fluid feed channel; whereinthe longitudinal axis L intersects the longitudinal axis F at an angle, defining an intersection plane I, and whereinat the distance H along longitudinal axis F, a plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected axis F, S being equal to or less than 2 times the inner diameter D1 of the compressed fluid feed channel. 10. The device of claim 9, further comprising a secondary liquid feed channel having a length and an inner diameter D4, and communicating between the second end of the liquid feed channel and the liquid holding means, wherein the inner diameter D4 is larger than the inner diameter D2 of the liquid feed channel. 11. The device of claim 9, wherein selected distance S is such that there is overlap of longitudinal axis F with the plane I-intersecting portion of the perimeter of the end wall face, wherein overlap is defined as being present if the longitudinal axis F intersects the end wall face or the liquid feed channel orifice thereof. 12. The device of claim 1, wherein the atomized liquid comprises particles, and the device further comprises a filtering member configured aerodynamically to filter particles from the atomized liquid having a size greater than a predetermined maximum size. 13. The device of claim 12, wherein the particle filtering member is in fluid communication with the atomization means, the particle filtering member having a surface contour and positioned at a distance of at least J along a longitudinal axis F from a primary orifice plane P to provide an aerodynamic fluid flow around the surface, and wherein the particle filtering member is held at a distance J along the longitudinal axis F by at least one filter support member communicating with the wall of the atomization chamber, the support member configured to operatively direct liquid accumulating on the filter away from the filter member for return to the liquid holding means. 14. The device of claim 1, further comprising a particle dispersion chamber configured to receive the atomized liquid and impart a predetermined flow pattern thereto, wherein the imparted fluid flow pattern comprises at least one of vortical flow, turbulent flow and randomized flow. 15. The device of claim 14, wherein the particle dispersion chamber comprises a chamber wall and an input opening and an output opening with an internal channel therebetween, the input opening in fluid communication with the atomization chamber, the dispersion chamber having at least one directed fluid output configured to impart a fluid flow pattern to the atomized particles within and exiting the dispersion chamber output opening. 16. The device of claim 15, additionally comprising: a secondary compressed fluid channel intermediate between the compressed fluid feed channel and a source of compressed fluid; and a particle dispersion chamber feed channel communicating between the secondary compressed fluid channel and the at least one directed compressed fluid output and corresponding orifices. 17. The device of claim 14, wherein the imparted fluid flow pattern is vortical flow. 18. The device of claim 1, further comprising a nasal, ocular, oral or vicinity adapter in communication with the atomization means. 19. The device of claim 1, wherein the liquid for atomization comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, emulsions, perfumes, fragrances, essential oils, cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents, aromatherapeutic agents, beverages, and skin treatments. 20. The device of claim 1, wherein the liquid feed channel has an internal diameter D2 at the liquid feed channel exit orifice, the compressed fluid feed channel having an internal diameter D1 at the compressed fluid exit orifice, and wherein D2 is equal to or greater than D1. 21. A method for generating and delivering an aerosol, comprising: providing a liquid in a liquid feed tube having a liquid feed channel with an inlet aperture a liquid feed channel exit orifice, an end-wall face and a sidewall, wherein the end wall face is between the liquid feed channel exit orifice and the perimeter of the liquid feed tube and is normal or substantially normal to a diverting portion of the sidewall of the liquid feed tube; anddirecting a pressurized fluid through a compressed fluid feed channel having a compressed fluid exit orifice, the compressed fluid exit orifice being spaced from the diverting portion of the sidewall, the compressed fluid exit orifice being configured to direct a stream of compressed fluid toward the diverting portion of the sidewall, the diverting portion of the sidewall being configured to disrupt a portion of the stream of compressed fluid, the disrupted portion of the stream of compressed fluid being configured to atomize a liquid from the liquid feed exit orifice, wherein generating and delivering an aerosol is afforded. 22. The method of claim 21, comprising imparting a vortical flow pattern to the aerosol to provide for delivering the aerosol having atomized particles in the vortical flow pattern.
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