An ocular implant having a body extending along a generally curved longitudinal axis, the curved longitudinal axis defining a first plane, the body having a diameter of between 0.005 inches and 0.04 inches and being adapted to be disposed within a canal of Schlemm in a human subject's eye; wherein t
An ocular implant having a body extending along a generally curved longitudinal axis, the curved longitudinal axis defining a first plane, the body having a diameter of between 0.005 inches and 0.04 inches and being adapted to be disposed within a canal of Schlemm in a human subject's eye; wherein the body has a first flexibility when bent along the first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane. Another aspect of the invention provides a method of treating a human eye, including the steps of: inserting an implant into Schlemm's canal of a human eye, the implant having a first flexibility when bent along a first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane; and supporting tissue forming Schlemm's canal with the implant.
대표청구항▼
1. An ocular implant adapted to be disposed within a canal of Schlemm in a human subject's eye, the implant comprising a body comprising: first, second and third spine sections, each spine having a circumferential extent;a frame extending between the first and second spine sections, and a frame exte
1. An ocular implant adapted to be disposed within a canal of Schlemm in a human subject's eye, the implant comprising a body comprising: first, second and third spine sections, each spine having a circumferential extent;a frame extending between the first and second spine sections, and a frame extending between the second and third spine sections, each frame comprising two struts, each frame having a circumferential extent greater than the circumferential extent of an adjacent spine; andan elongate opening disposed on an outer side of the body and defined along its entire length by the circumferential extents of the spine sections and the circumferential extents of the frames, the circumferential extents of the spine sections and the circumferential extents of the frames being less than 360 degrees so that the elongate opening extends continuously along the spine sections and the frames;the spine sections and frames being disposed in a cylindrical volume having a curved longitudinal axis and a diameter of between 0.005 inches and 0.04 inches, the curved longitudinal axis defining a first plane;the body having a first flexibility when bent along the first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane. 2. The ocular implant of claim 1, wherein the elongate opening opens radially outward when the body is unrestrained. 3. The ocular implant of claim 1, wherein the body has a shape that is symmetric about the first plane. 4. The ocular implant of claim 1, wherein each spine has a shape that is symmetric about the first plane. 5. The ocular implant of claim 1, wherein: each spine comprises a first minor side, a first major side, a second minor side, and a second major side;each spine having a thickness extending between at least one point on each major side and at least one point on the second major side;each spine having a width extending between at least one point on each minor side and at least one point on the second minor side;an aspect ratio of the width to the thickness being greater than about 2. 6. The ocular implant of claim 5, wherein the first major side comprises a concave surface. 7. The ocular implant of claim 6, wherein the second major side comprises a convex surface. 8. The ocular implant of claim 7, wherein the concave surface and the convex surface are concentric. 9. The ocular implant of claim 5, wherein the first major side and the second major side are opposite one another. 10. The ocular implant of claim 1, wherein the spines are longitudinally aligned with one another. 11. The ocular implant of claim 1, wherein each frame has a shape that is symmetric about the first plane. 12. The ocular implant of claim 1, wherein each strut follows a circumferentially undulating path while extending longitudinally between a first spine and a second spine. 13. The ocular implant of claim 1, wherein: each strut comprises a first minor side, a first major side, a second minor side, and a second major side;each strut having a thickness extending between at least one point on the first major side and at least one point on the second major side;each strut having a width extending between at least one point on the first minor side and at least one point on the second minor side;an aspect ratio of the width to the thickness being greater than about 2. 14. The ocular implant of claim 13, wherein the first major side comprises a concave surface. 15. The ocular implant of claim 13, wherein the second major side comprises a convex surface. 16. The ocular implant of claim 13, wherein the concave surface and the convex surface are concentric. 17. The ocular implant of claim 13, wherein the first major side and the second major side are opposite one another. 18. The ocular implant of claim 1, wherein the body exhibits superelastic properties. 19. The ocular implant of claim 1, wherein the body comprises nickel and titanium. 20. The ocular implant of claim 19, wherein the weight percent of nickel is between about 29.5 and about 50.5 weight percent and the weight percent of titanium is between about 29.5 and about 50.5 weight percent, based upon the total weight percent of the alloy. 21. The ocular implant of claim 1 wherein the body extends through an arcuate range between about 60 degrees and about 180 degrees. 22. The ocular implant of claim 1 further comprising a therapeutic agent deposited on the body. 23. The ocular implant of claim 22 wherein the therapeutic agent comprises an anti-glaucoma drug. 24. The ocular implant of claim 23, wherein the anti-glaucoma drug comprises a prostaglandin analog. 25. The ocular implant of claim 24, wherein the prostaglandin analog comprises latanprost. 26. The ocular implant of claim 1 wherein the elongate opening is disposed in the first plane.
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