Apparatus and method for perfusion and determining the viability of an organ
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-001/00
A01N-001/02
출원번호
US-0845154
(2004-05-14)
등록번호
US-8741555
(2014-06-03)
발명자
/ 주소
Brassil, John
Baicu, Simona
출원인 / 주소
Organ Recovery Systems, Inc.
대리인 / 주소
Oliff PLC
인용정보
피인용 횟수 :
0인용 특허 :
20
초록▼
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.
대표청구항▼
1. A method of determining at least one characteristic of at least one specific area of an organ, comprising: perfusing the organ with an oxygen rich fluid to maintain viability of the organ;placing at least one device at or in at least one specific area of the organ where the at least one character
1. A method of determining at least one characteristic of at least one specific area of an organ, comprising: perfusing the organ with an oxygen rich fluid to maintain viability of the organ;placing at least one device at or in at least one specific area of the organ where the at least one characteristic of the specific area of the organ will be monitored;separately from the perfusing, supplying a first medical fluid to the at least one specific area of the organ, and not the entire organ, and performing microdialysis at the at least one specific area of the organ, wherein the first medical fluid is a dialysate; andmonitoring an output of the at least one device, wherein the output is at least one of a sensed electrical characteristic and a sensed chemical characteristic of only the at least one specific area of the organ. 2. The method of claim 1, wherein at least one of the at least one device contains a second medical fluid. 3. The method of claim 2, further comprising allowing at least one of a fluid exposure and a fluid exchange through a semipermeable membrane between the second medical fluid and fluid located in the organ at or near the at least one specific area. 4. The method of claim 3, further comprising generating data based on the at least one fluid exposure or exchange between the second medical fluid of the at least one device and fluid located in the organ at or near the at least one specific area. 5. The method of claim 4, further comprising at least one of displaying the generated data in real time, storing the generated data, transmitting the generated data to a remote site, transferring the generated data to a recording medium, and transmitting the generated data to a microprocessor. 6. The method of claim 1, further comprising adjusting the perfusion of the organ based on the output. 7. The method of claim 4, wherein the output relates to at least one of pH, ion levels, metabolism, excretion, and gas levels. 8. The method of claim 3, further comprising: supplying the second medical fluid to the at least one device through a first tube; andremoving a third medical fluid from the at least one device through a second tube. 9. The method of claim 8, further comprising collecting the third medical fluid. 10. The method of claim 9, further comprising sensing at least one of an electrical characteristic and a chemical characteristic of the at least one specific area of the organ from the collected third medical fluid. 11. The method of claim 10, further comprising comparing the at least one electrical or chemical characteristic of the third medical fluid to at least one characteristic of the first and second medical fluids. 12. The method of claim 11, wherein characteristics of the second medical fluid are known. 13. The method of claim 11, wherein the comparing is performed by a fluid-testing device. 14. The method of claim 11, further comprising generating data based on the compared characteristics. 15. The method of claim 14, further comprising transferring the generated data wirelessly to a remote location for at least one of managing, tracking, monitoring, and diagnosing the organ. 16. The method of claim 14, further comprising transferring the generated data to a computer network, wherein the computer network at least one of manages, tracks, monitors, and diagnoses the organ. 17. The method of claim 16, further comprising at least one of displaying, accessing, and uploading the data from the computer network, wherein the computer network is at least one of a local area network and the Internet. 18. The method of claim 10, wherein the electrical or chemical characteristic relates to at least one of pH, ion levels, metabolism, excretion and gas levels. 19. The method of claim 4, wherein the first and second medical fluids are different fluids. 20. The method of claim 4, wherein the first and second medical fluids are the same fluids. 21. The method of claim 1, wherein at least one of the at least one device is a sensor. 22. The method of claim 21, wherein the sensor is a solid-state transducer. 23. The method of claim 21, wherein the at least one device includes a microprocessor that generates data based on at least one of the sensed electrical characteristic and sensed chemical characteristic of the at least one specific area of the organ. 24. The method of claim 23, wherein the microprocessor causes the data to be at least one of displayed in real time, stored, transmitted to a remote site, and transferred to a recording medium. 25. The method of claim 24, further comprising controlling the perfusion based on the at least one sensed electrical or chemical characteristics. 26. The method of claim 23, wherein the at least one sensed electrical or chemical characteristic relates to at least one of pH, ion levels, metabolism, excretion, and gas levels. 27. The method of claim 1, wherein only the at least one specific area of the organ is supplied with the first medical fluid. 28. The method of claim 1, further comprising monitoring at least one of pH, ion levels, metabolism, excretion, or gas levels of the oxygen rich fluid that has been passed through the organ. 29. The method of claim 28, wherein the monitoring at least one of pH, ion levels, metabolism, excretion, or gas levels of the outflow of the oxygen rich fluid that was perfused to maintain viability of the organ occurs simultaneously with the monitoring of the output of the at least one device, wherein the output is at least one of a sensed electrical characteristic and a sensed chemical characteristic of only the at least one specific area of the organ. 30. The method of claim 29, further comprising at least one of displaying the generated data in real time, storing the generated data, transmitting the generated data to a remote site, transferring the generated data to a recording medium, and transmitting the generated data to a microprocessor. 31. The method of claim 29, further comprising adjusting the perfusion of the organ based on the at least one of pH, ion levels, metabolism, excretion, or gas levels of the outflow of the oxygen rich fluid that was perfused to maintain viability of the organ and the output of the at least one device, wherein the output is at least one of a sensed electrical characteristic and a sensed chemical characteristic of only the at least one specific area of the organ.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (20)
Dietz Corine M. ; Gibbons Jacqueline A. ; Taylor Eric W., ADME analysis of mixtures.
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
Martindale James G. (Costa Mesa CA) Purdy Ralph E. (Irvine CA) Stupecky George L. (Irvine CA) Tidwell Ronny G. (Irvine CA), Apparatus and method of preserving the viability of animal organs.
Fisher Robyn (15555 N. Oracle Rd. Tucson AZ 85737) Brendel Klaus (3231 N. Manor Dr. Tucson AZ 85715), Cold and cryo-preservation methods for human tissue slices.
Sterman, Wesley D.; Stevens, John H.; Gifford, III, Hanson S.; Siegel, Lawrence C.; Putnam, Joe B., Methods and apparatus for perfusion of isolated tissue structure.
Bacchi Bernard,FRX ; Marchot Patrick,FRX ; Mauriat Philippe,FRX ; Pouard Philippe,FRX ; Touati Gilles,FRX ; Magnard Alain,FRX ; Muller Fernard,LUX, Probe assembly and apparatus for measuring the PH of a tissue of a human or animal organ.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.