Cannula for minimizing dilution of dosing during nitric oxide delivery
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-015/08
A62B-007/00
A61M-015/00
A61M-016/10
A61M-016/00
A61M-016/06
A61M-016/12
A61M-016/20
출원번호
US-0096629
(2013-12-04)
등록번호
US-8770199
(2014-07-08)
발명자
/ 주소
Flanagan, Craig
Freed, Simon
Klaus, John
Kohlmann, Thomas
Meglasson, Martin D.
Naidu, Manesh
Shah, Parag
출원인 / 주소
INO Therapeutics LLC
대리인 / 주소
Servilla Whitney LLC
인용정보
피인용 횟수 :
5인용 특허 :
352
초록▼
The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of
The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
대표청구항▼
1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising: a first lumen, a second lumen, and a third lumen: the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas to a patient in need thereof,the second lumen being a triggering lum
1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising: a first lumen, a second lumen, and a third lumen: the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas to a patient in need thereof,the second lumen being a triggering lumen, andthe third lumen being a second therapeutic gas lumen for delivering a second therapeutic gas to the patient;a cannula nosepiece aggregating, and allowing separate flow paths to the patient for, each of (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen; andwherein the first lumen has an inner diameter that is smaller than an inner diameters of the second lumen and third lumen but larger than an inner diameter of the flow path for the first lumen at the cannula nosepiece. 2. The nasal cannula of claim 1, wherein the nasal cannula (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both. 3. The nasal cannula of claim 1, wherein the nasal cannula at least one of inhibits mixing of nitric oxide and oxygen and reduces delivery of nitrogen dioxide to the patient. 4. The nasal cannula of claim 1, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of pulmonary hypertension. 5. The nasal cannula of claim 1, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of at least one of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), pulmonary hypertension as pulmonary arterial hypertension (PAH), pulmonary hypertension secondary to idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension secondary to sarcoidosis. 6. The nasal cannula of claim 1, wherein the first therapeutic gas is nitric oxide and the second therapeutic gas is oxygen. 7. The nasal cannula of claim 1, wherein the first therapeutic gas is nitric oxide and the first therapeutic gas lumen for delivering nitric oxide is about six feet to about eight feet in length having an inner diameter of about 0.01 inches to about 0.10 inches. 8. The nasal cannula of claim 1, wherein the first therapeutic gas is nitric oxide. 9. The nasal cannula of claim 1, wherein the first therapeutic gas is nitric oxide and the cannula nosepiece comprises a nitric oxide flow path having a volume defined by the region extending between exits of a first and second nasal cannula nare that is less than about 10% of a minimum pulse volume of the pulse of nitric oxide. 10. The nasal cannula of claim 1, wherein the cannula comprises a wall material having a low oxygen transmission rate that is between 0.001(cc)(mil)(24hrs)(100in2)(ATM)and10(cc)(mil)(24hrs)(100in2)(ATM). 11. The nasal cannula of claim 1, wherein the cannula is further comprising a fourth lumen: the fourth lumen being another first therapeutic gas lumen for delivering the first therapeutic gas to the patient; andwherein the first lumen delivers the first therapeutic gas to one nostril of the patient and the fourth lumen delivers the first therapeutic gas to another nostril of the patient. 12. The nasal cannula of claim 1, further comprising one or more of: (i) at least one check valve in fluid communication with the first therapeutic gas lumen, (ii) a cannula key, (iii) a scavenging material, and (iv) a flexible support bridge. 13. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising: a first lumen, a second lumen, and a third lumen: the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas to a patient,the second lumen being a triggering lumen for triggering release of a pulse of the first therapeutic gas, andthe third lumen being a second therapeutic gas lumen for delivering a second therapeutic gas to the patient;the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen aggregating at a cannula nosepiece, the cannula nosepiece allowing separate flow paths to the patient for each of the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen; andthe first therapeutic gas lumen having an inner diameter that is (i) smaller than an inner diameter of the second therapeutic gas lumen and an inner diameter of the triggering lumen and (ii) larger than an inner diameter of the flow path for the first therapeutic gas lumen at the cannula nosepiece. 14. The nasal cannula of claim 13, wherein the nasal cannula (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both. 15. The nasal cannula of claim 13, wherein the nasal cannula at least one of inhibits mixing of nitric oxide and oxygen and reduces delivery of nitrogen dioxide to the patient. 16. The nasal cannula of claim 13, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of pulmonary hypertension. 17. The nasal cannula of claim 13, wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of at least one of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), pulmonary hypertension as pulmonary arterial hypertension (PAH), pulmonary hypertension secondary to idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension secondary to sarcoidosis. 18. The nasal cannula of claim 13, wherein the first therapeutic gas is nitric oxide and the first therapeutic gas lumen for delivering nitric oxide is about six feet to about eight feet in length having an inner diameter of about 0.01 inches to about 0.10 inches. 19. The nasal cannula of claim 13, wherein the first therapeutic gas is nitric oxide and the cannula nosepiece comprises a nitric oxide flow path having a volume defined by the region extending between exits of a first and second nasal cannula nare that is less than about 10% of a minimum pulse volume of the pulse of nitric oxide. 20. The nasal cannula of claim 13, wherein the cannula comprises a wall material having a low oxygen transmission rate that is between 0.001(cc)(mil)(24hrs)(100in2)(ATM)and10(cc)(mil)(24hrs)(100in2)(ATM). 21. The nasal cannula of claim 13, further comprising one or more of: (i) at least one check valve in fluid communication with the first therapeutic gas lumen, (ii) a cannula key, (iii) a scavenging material, and (iv) a flexible support bridge. 22. A nasal cannula for therapeutic gas delivered to a patient, comprising: a first lumen, a second lumen, and a third lumen: the first lumen being a first therapeutic gas lumen for delivering nitric oxide gas to a patient,the second lumen being a triggering lumen, andthe third lumen being a second therapeutic gas lumen for delivering one or more of oxygen gas and air gas to the patient;the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen aggregating at a cannula nosepiece, the cannula nosepiece allowing separate flow paths to the patient for each of the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen;the flow path for the first therapeutic gas lumen for delivering nitric oxide to the patient having a volume defined by the region extending between exits of a first and second nasal cannula nare at the cannula nosepiece that is less than about 10% of a minimum pulse volume of the pulse of nitric oxide;the first therapeutic gas lumen having an inner diameter that is smaller than an inner diameter of the second therapeutic gas lumen and an inner diameter of the triggering lumen; andthe first therapeutic gas lumen having an inner diameter that is larger than an inner diameter of the flow path for the first therapeutic gas lumen at the cannula nosepiece. 23. A method for treating pulmonary hypertension, comprising: administering nitric oxide gas to a patient through a nasal cannula, wherein the nasal cannula comprises: a first lumen, a second lumen, and a third lumen: the first lumen being a first therapeutic gas lumen for delivering a nitric oxide gas to a patient,the second lumen being a triggering lumen for sensing the onset of inspiration or a change in pressure, andthe third lumen being a second therapeutic gas lumen for delivering oxygen gas to the patient; anda cannula nosepiece aggregating, and allowing separate flow paths to the patient for, each of (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen;wherein the first lumen has an inner diameter that is smaller than an inner diameters of the second lumen and third lumen but larger than an inner diameter of the flow path for the first lumen at the cannula nosepiece. 24. The method of claim 23, wherein the nasal cannula one or more of (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient and (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient. 25. The method of claim 23, wherein the nasal cannula at least one of inhibits mixing of nitric oxide and oxygen and reduces delivery of nitrogen dioxide to the patient. 26. The method of claim 23, wherein the cannula nosepiece comprises a nitric oxide flow path having a volume defined by the region extending between exits of a first and second nasal cannula nare that is less than about 10% of a minimum pulse volume of the pulse of nitric oxide. 27. The method of claim 23, wherein the cannula comprises a wall material having a low oxygen transmission rate that is between 0.001(cc)(mil)(24hrs)(100in2)(ATM)and10(cc)(mil)(24hrs)(100in2)(ATM). 28. The method of claim 23, further comprising one or more of: (i) at least one check valve in fluid communication with the first therapeutic gas lumen, (ii) a cannula key, (iii) a scavenging material, and (iv) a flexible support bridge that cushions the patient's nasal septum.
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