[특허]Frozen compositions and array devices thereof

The Invention Science Fund I, LLC

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특허 상세정보

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내보내기 페이스북 공유 트위터 공유 카카오톡 공유

Frozen compositions and array devices thereof

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-037/00 A61K-009/00
미국특허분류(USC)	604/173;
출원번호	US-0586073 (2009-09-15)
등록번호	US-8784384 (2014-07-22)
발명자 / 주소	Boyden, Edward S. Cook, Daniel B. Hyde, Roderick A. Leuthardt, Eric C. Myhrvold, Nathan P. Sweeney, Elizabeth A. Wood, Jr., Lowell L.
출원인 / 주소	The Invention Science Fund I, LLC
인용정보	피인용 횟수 : 4 인용 특허 : 133

초록

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

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1. An array device, comprising: a support structure having a surface; anda plurality of sterile frozen ice therapeutic composition piercing implements extending substantially outward from the support structure, the implements consisting essentially of sterile ice and including at least one internal channel containing at least one anti-inflammatory agent. 2. The array device of claim 1, wherein the plurality of sterile frozen piercing implements extends substantially perpendicular to the support structure. 3. The array device of claim 1, wherein the support structure includes at least one frozen composition. 4. The array device of claim 1, wherein the support structure is at least partially frozen. 5. The array device of claim 1, wherein the support structure and at least one frozen piercing implement of the plurality of frozen piercing implements include at least one common constituent. 6. The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially parallel to each other. 7. The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially in a predetermined spatial pattern. 8. The array device of claim 7, wherein the predetermined spatial pattern is at least partially periodic. 9. The array device of claim 1, wherein the plurality of frozen piercing implements include approximately the same length. 10. The array device of claim 1, wherein the length of a frozen piercing implement corresponds to the position or location of the frozen piercing implement in the array device. 11. The array device of claim 1, wherein the length of a frozen piercing implement is actuatable. 12. The array device of claim 1, wherein at least one frozen piercing implement is configured to be deactivated. 13. The array device of claim 12, wherein the at least one frozen piercing implement is configured to be deactivated by at least one component of the array device or the frozen piercing implement. 14. The array device of claim 13, wherein the at least one frozen piercing implement is configured to be deactivated by thermal transfer to the at least one frozen piercing implement. 15. The array device of claim 1, wherein the plurality of frozen piercing implements is positioned as at least a portion of a fluidic or injection device. 16. The array device of claim 1, wherein the plurality of frozen piercing implements is positioned in fluid communication with at least one compartment configured to be mechanically regulated. 17. The array device of claim 1, wherein at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter. 18. The array device of claim 1, wherein at least one frozen piercing implement of the plurality further includes at least one vitamin, mineral, cell growth promoter, angiogenic factor, hormone, cytokine, or anesthetic agent. 19. The array device of claim 18, wherein each frozen piercing implement of the plurality includes at least one agent different than the agent of every other frozen piercing implement of the plurality. 20. The array device of claim 18, wherein the device includes at least two different agents. 21. The array device of claim 1, wherein the frozen piercing implement is configured for delivering the at least one agent. 22. The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implements have at least one agent in common. 23. The array device of claim 1, wherein each frozen piercing implement of the plurality of frozen piercing implements is different from every other piercing implement by varying one or more of: size of implement, shape of implement, or constitution of implement. 24. The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implement differ in one or more of: size of implement, shape of implement, or constitution of implement. 25. The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including a regular or irregular shape. 26. The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including at least one of a rectangle, square, circle, triangle, or polygon. 27. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one functionalized surface. 28. The array device of claim 27, wherein the at least one functionalized surface includes one or more functionalities including one or more of charge functionality, hydrophobic functionality, hydrophilic functionality, chemically reactive functionality, or wettability. 29. The array device of claim 27, wherein the at least one functionalized surface includes one or more functional groups including at least one of an agent, alcohol, hydroxyl, amine, aldehyde, dye, ketone, carbonyl, thiol, alkoxysilane, phosphate, carboxyl, carboxylic acid, carboxylate, nucleic acid, amino acid, polypeptide, protein, lipid, carbohydrate, metal, —NH3+, —COOH, —COO—, —SO3, CH2N+(CH3)3, —(CH2)xCH3, —C((CH2)xCF3)3, —CH2N(C2H5)2, —NH2, —(CH2)xCOOH, —(OCH2CH2)xCH3, —SiOH, or —OH. 30. The array device of claim 27, wherein the at least one functionalized surface includes at least part of an outer surface. 31. The array device of claim 27, wherein the at least one functionalized surface includes at least part of an inner surface. 32. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one inlet port. 33. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one outlet port. 34. The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements includes at least one sensor. 35. The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements is configured for extracting at least one material from at least one substrate. 36. The array device of claim 1, further including at least one attachment component configured to secure the array device to at least one substrate. 37. The array device of claim 36, wherein the at least one attachment component includes at least one adhesive material. 38. The array device of claim 1, wherein the device is configured to substantially form a patch. 39. The array device of claim 1, further including at least one compartment. 40. The array device of claim 39, wherein the at least one compartment includes at least one syringe or at least one valve. 41. The array device of claim 39, wherein the at least one compartment is configured to hold at least one material extracted from at least one substrate. 42. The array device of claim 1, further including at least one of an adhesive agent, reinforcement agent, abrasive, biological remodeling agent, or explosive material. 43. The array device of claim 1, further including at least one compartment in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements. 44. The array device of claim 43, wherein the at least one compartment is configured for holding at least one agent. 45. The array device of claim 43, wherein the at least one compartment is configured for holding at least one cryogenic substance. 46. The array device of claim 43, further including a plurality of compartments in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements. 47. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one different substance from at least one second compartment. 48. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, wherein the at least one first agent is different from at least one other agent located in at least one second compartment. 49. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, and at least one second compartment configured to hold a pharmaceutically acceptable carrier or excipient. 50. The array device of claim 1, wherein the array device is in electronic communication with at least one computing device. 51. The array device of claim 1, further including a heater. 52. An array device, comprising: a support structure having a surface;a plurality of sterile frozen ice therapeutic composition piercing implements consisting essentially of sterile ice and extending substantially outward from the support structure, at least one of the plurality of sterile frozen ice therapeutic composition piercing implements including one or more antibiotics;and an attachment component configured for securing to a biological tissue.

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