Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-038/31
A61K-047/48
A61L-031/14
A61L-031/04
출원번호
US-0260394
(2008-10-29)
등록번호
US-8790698
(2014-07-29)
발명자
/ 주소
Odar, Johann
Nistor-Gallo, Raymond
Caliari, Laura
출원인 / 주소
Baxter International Inc.
대리인 / 주소
Kilpatrick Townsend Stockton LLP
인용정보
피인용 횟수 :
0인용 특허 :
120
초록▼
Techniques for treating visceral or parietal membrane and tissue defects include the application of a collagen biomatrix to the defect to repair and regenerate a visceral or parietal membrane, for example in patients suffering tissue defects or undergoing visceral or parietal surgical treatment. Suc
Techniques for treating visceral or parietal membrane and tissue defects include the application of a collagen biomatrix to the defect to repair and regenerate a visceral or parietal membrane, for example in patients suffering tissue defects or undergoing visceral or parietal surgical treatment. Such approaches avoid persistent tissue leaks and their consequences such as fluid leaks and air leaks. The use of collagen biomatrix, optionally in conjunction with a fibrin sealant, an anti-adhesive, or both, can minimize tissue leaks or fluid leaks in injured patients suffering tissue defects or subjects undergoing surgery such as visceral or parietal resections and other operations.
대표청구항▼
1. A method for treating a disorder in a patient characterized by a defect of a visceral or parietal membrane, comprising the step of administering to the defect a biofunctional nonporous multilayered collagen foil biomatrix which directs visceral or parietal cell growth within interstices of the mu
1. A method for treating a disorder in a patient characterized by a defect of a visceral or parietal membrane, comprising the step of administering to the defect a biofunctional nonporous multilayered collagen foil biomatrix which directs visceral or parietal cell growth within interstices of the multilayered collagen foil biomatrix, wherein a material comprising a polyethylene glycol that is separate from the biomatrix is applied to the multilayered collagen foil biomatrix on a first surface of the multilayered collagen foil biomatrix that is to face away from the defect to which the biomatrix is administered and not on a second surface of the multilayered collagen foil biomatrix that faces the defect. 2. The method according to claim 1, wherein the multilayered collagen foil biomatrix forms a substantially liquid tight and air tight layer between the visceral or parietal defect and an adjacent tissue. 3. The method according to claim 1, wherein the administering step comprises one or more methods selected from the group consisting of: attaching the multilayered collagen foil biomatrix to the visceral or parietal defect with fibrin sealant, attaching the multilayered collagen foil biomatrix to the visceral or parietal defect with surgical sealant, attaching the multilayered collagen foil biomatrix to the visceral or parietal defect with surgical sutures, utilizing pressure fitting techniques, and utilizing natural adhesion between the multilayered collagen foil biomatrix and the visceral or parietal defect. 4. The method according to claim 3, wherein the multilayered collagen foil biomatrix is attached to the visceral or parietal defect of the patient using a fibrin sealant. 5. The method according to claim 1, wherein the biomatrix does not promote adhesions with an adjacent tissue after cell growth within interstices of the multilayered collagen foil biomatrix. 6. The method according to claim 1, wherein the multilayered collagen foil biomatrix directs cell growth on the outer surface of the multilayered collagen foil biomatrix. 7. The method according to claim 1, wherein the multilayered collagen foil biomatrix comprises an excipient selected from the group consisting of an antibiotic, a preservative, and a growth factor. 8. The method according to claim 1, wherein the multilayered collagen foil biomatrix comprises collagen derived from a source selected from the group consisting of a bovine source, a porcine source, an equine source, an ovine source, a primate source, a rodentia source, and a human source. 9. The method according to claim 1, wherein the multilayered collagen foil biomatrix comprises collagen derived from tendon tissue. 10. The method according to claim 1, wherein the defect comprises a defect of a pleural membrane, and wherein the biofunctional nonporous multilayered collagen foil biomatrix directs pleural cell growth within interstices of the multilayered collagen foil biomatrix. 11. The method according to claim 1, wherein the material comprising polyethylene glycol is applied to the multilayered collagen foil biomatrix prior to administering the multilayered collagen foil biomatrix to the defect. 12. The method according to claim 1, wherein the material comprising polyethylene glycol is applied to the multilayered collagen foil biomatrix subsequent to administering the multilayered collagen foil biomatrix to the defect. 13. The method according to claim 12, wherein the material comprising polyethylene glycol is also applied to tissue adjacent to the defect to which the multilayered collagen foil biomatrix is administered. 14. A method for regenerating a visceral or parietal membrane in a mammal, comprising contacting a defect in the visceral or parietal membrane with a collagen foil comprising a non-naturally occurring biomatrix of multiple layers of collagen fibrils that are not cross-linked by chemicals or radiation, wherein the biomatrix is substantially nonporous, wherein the biomatrix directs visceral or parietal cell growth within interstices of the multilayered collagen foil biomatrix, and wherein a material comprising polyethylene glycol that is separate from the biomatrix is applied to the multilayered collagen foil biomatrix on a first surface of the multilayered collagen foil biomatrix that is to face away from the defect to which the biomatrix is administered and not on a second surface of the multilayered collagen foil biomatrix that faces the defect. 15. The method according to claim 14, wherein the multilayered collagen foil biomatrix forms a substantially liquid tight and air tight layer between the visceral or parietal membrane and an adjacent tissue. 16. The method according to claim 14, wherein the multilayered collagen foil biomatrix is attached to the visceral or parietal defect of the patient using a fibrin sealant. 17. The method according to claim 14, wherein the biomatrix does not promote adhesions with an adjacent tissue after cell growth within interstices of the multilayered collagen foil biomatrix. 18. The method according to claim 14, wherein the defect comprises a defect of a pleural membrane, and wherein the biofunctional nonporous multilayered collagen foil biomatrix directs pleural cell growth within interstices of the multilayered collagen foil biomatrix. 19. A method for directed cell in-growth and controlled tissue regeneration of a visceral or parietal membrane to prevent post-surgical or post-traumatic adhesion and fibrosis formation on the surface of a tissue in a mammal, comprising contacting the tissue with a nonporous microscopically multilayered collagen foil biomatrix, wherein the biomatrix directs visceral or parietal cell growth within interstices of the multilayered collagen foil biomatrix, and wherein a material comprising polyethylene glycol that is separate from the biomatrix is applied to the multilayered collagen foil biomatrix on a first surface of the multilayered collagen foil biomatrix that is to face away from the defect to which the biomatrix is administered and not on a second surface of the multilayered collagen foil biomatrix that faces the defect. 20. The method according to claim 19, wherein the multilayered collagen foil biomatrix forms a substantially liquid tight and air tight layer between a visceral or parietal membrane defect and an adjacent tissue. 21. The method according to claim 19, wherein the multilayered collagen foil biomatrix is attached to the visceral or parietal membrane defect of the patient using a fibrin sealant. 22. The method according to claim 19, wherein the biomatrix does not promote adhesions with an adjacent tissue after cell growth within interstices of the multilayered collagen foil biomatrix. 23. The method according to claim 19, wherein the visceral or parietal membrane comprises a pleural membrane, and wherein the nonporous microscopically multilayered collagen foil biomatrix directs pleural cell growth within interstices of the multilayered collagen foil biomatrix.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (120)
Kowanko Nicholas (618 S. Fifth St. Moorhead MN 56560), Adhesive composition and method.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Tay Sew-Wah (Plymouth MN) Schankereli Kemal (Stillwater MN) Holman Thomas (Minneapolis MN) Mische Hans (St. Cloud MN), Apparatus and method for sealing vascular punctures.
Tardy Michel (Lyons FRX) Tiollier Jerome (Lyons FRX) Tayot Jean-Louis (La Tour De Salvagny FRX), Biocompatible bioresorbable and non-toxic adhesive composition for surgical use.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Silver Fred (Bangor PA) Sharma Vinay (Long Valley NJ) Berndt Dieter R. (Allenwood NJ) Marn Louis E. (Morris Plains NJ), Collagen-based wound dressing and method for applying same.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Henry Raymond L. (Grosse Pointe Woods MI), Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers an.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Olof Mikael Trollsas ; Donald G. Wallace ; Frank A. DeLustro, Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use.
Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Dexter MI) Levinson Robert S. (Chesterfield MO), Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers.
Qian, Zhen; Osawa, A. Edward; Reich, Cary J.; Wallace, Donald G.; Shargill, Narinder S.; Vega, Felix, Dry hemostatic compositions and methods for their preparation.
Narotam Pradeep K.,CAX ; van Dellen James R.,ZAX ; O'Fee Robert P. ; McKinney ; III George W. ; Archibald Simon J. ; O'Grady Judith, Dural/meningeal repair product using collagen matrix.
Wallace Donald G. (Menlo Park CA) McMullin Hugh (Pacifica CA) Chu George (Cupertino CA), Injectable ceramic compositions and methods for their preparation and use.
Wallace Donald G. (Menlo Park) McMullin Hugh (Pacifica) Chu George (Cupertino CA), Injectable ceramic compositions and methods for their preparation and use.
Wallace Donald G. (Menlo Park CA) Reihanian Hertsel (San Francisco CA) Pharriss Bruce B. (Palo Alto CA) Braun William G. (Los Altos CA), Injectable implant composition having improved intrudability.
Etienne Schacht BE; An Van Den Bulcke BE; Bernard Delaey BE; Jean-Pierre Draye BE, Medicaments based on polymers composed of methacrylamide-modified gelatin.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Wahlig Helmut (Darmstadt DEX) Dingeldein Elvira (Dreieich DEX) Braun Dietrich (Darmstadt DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Goldberg Eugene P. (Gainesville FL) Yaacobi Yoseph (Gainesville FL), Method and composition for preventing surgical adhesions using a dilute solution of polymer.
Eibl Johann (Vienna ATX) Schwarz Otto (Vienna ATX) Elsinger Fritz (Vienna ATX) Wber Gnter (Oberwaltersdorf ATX) Philapitsch Anton (Ebenfurt ATX) Linnau Yendra (Vienna ATX) Dorner Friedrich (Vienna AT, Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood produc.
Sawyer Philip N. (Brooklyn NY) Sawyer Philip M. (Menlo Park CA) Reich Cary J. (Laguna Hills CA), Methods for sealing of staples and other fasteners in tissue.
Song Suk-Zu (Moorpark CA) Morawiecki Andrew (Camarillo CA) Pierce Glenn F. (Thousand Oaks CA) Pitt Colin G. (Westlake Village CA), Multi-layered collagen film compositions for delivery of proteins and methods of using same.
Saferstein Lowell (Edison NJ) Wolf Stephen (Neshanic Station NJ) Kamp Lola (Highland Park NJ) Linsky Cary (East Brunswick NJ) Wiseman David (Highland Park NJ), Process for preparing a neutralized oxidized cellulose product and its method of use.
Sharma Vinay K. (12 Walnut Dr. Long Valley NJ 07853), Process of preparing microparticulate collagen, collagen-based products thereby and method of applying same.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Wallace, Donald G.; Cruise, Gregory M.; Rhee, Woonza M.; Schroeder, Jacqueline Anne; Coker, III, George T.; Maroney, Marcee M.; Trollsas, Olof Mikael, Rapid-gelling biocompatible polymer composition and associated methods of preparation and use.
Kensey Kenneth (Chester Springs PA) Nash John E. (Downington PA) Evans Douglas (Devon PA), System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Hermes Matthew E. (Easton CT) Muth Ross R. (Brookfield CT) Gustafson Darel L. (Shelton CT), Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin.
Weldon Thomas D. (P.O. Box 5149 Aquadilla PR 00605) Larsen Charles E. (P.O. Box 5149 Aquadilla PR 00605), Wound treating device using an inflatable membrane and method for treating wounds.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.