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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0505684 (2010-11-05) |
등록번호 | US-8795727 (2014-08-05) |
국제출원번호 | PCT/US2010/055716 (2010-11-05) |
§371/§102 date | 20120606 (20120606) |
국제공개번호 | WO2011/057133 (2011-05-12) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 622 |
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and sy
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
1. A method of making a fragmented hydrogel composition, comprising: combining in an alkaline solution of at least 30 mM chitosan, carboxymethylcellulose, carboxymethylchitosan, or a derivative thereof with a molecular weight of less than or equal to 5000 Dalton, a degree of deacetylation of 30% to
1. A method of making a fragmented hydrogel composition, comprising: combining in an alkaline solution of at least 30 mM chitosan, carboxymethylcellulose, carboxymethylchitosan, or a derivative thereof with a molecular weight of less than or equal to 5000 Dalton, a degree of deacetylation of 30% to 100%, a degree of deacetylation greater than or equal to 70%, and a multi-armed polyethylene glycol with a molecular weight of 10,000 Dalton to 30,000 Dalton and at least two nucleophilic groups;combining a multi-armed polyethylene glycol with a molecular weight of 10,000 Dalton to 30,000 Dalton and at least two eletrophilic groups with an aqueous solution;combining the alkaline and aqueous solution;allowing the hydrogel composition to substantially cure;drying the substantially cured hydrogel composition under elevated temperature and reduced pressure; andfragmenting the dry hydrogel composition by cryogenic grinding or cryogenic milling. 2. A method of making a fragmented hydrogel composition, comprising: combining in an alkaline solution of at least 30 mM chitosan, carboxymethylcellulose, carboxymethylchitosan, or a derivative thereof with a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 30% to 100%, a degree of deacetylation greater than or equal to 70%, and a multi-armed polyethylene glycol with a molecular weight of 10,000 Dalton to 30,000 Dalton and at least two nucleophilic groups;combining a multi-armed polyethylene glycol with a molecular weight of 10,000 Dalton to 30,000 Dalton and at least two eletrophilic groups with an aqueous solution;combining the alkaline and aqueous solution;allowing the hydrogel composition to substantially cure;drying the substantially cured hydrogel composition under elevated temperature and reduced pressure;fragmenting the dry hydrogel composition into a collection of particles by cryogenic grinding or cryogenic milling;selecting a specific range of fragmenting hydrogel particulate; andmixing the selected fragmented hydrogel particulate with a liquid.
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