State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
대리인 / 주소
Klarquist Sparkman, LLP
인용정보
피인용 횟수 :
6인용 특허 :
91
초록▼
A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream
A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.
대표청구항▼
1. A medical system, comprising: a filtration system capable of filtering a water stream;a water purification system capable of purifying said water stream in a non-batch process, comprising a microfluidic heat exchange system comprising a dwell chamber, wherein the water stream is maintained in the
1. A medical system, comprising: a filtration system capable of filtering a water stream;a water purification system capable of purifying said water stream in a non-batch process, comprising a microfluidic heat exchange system comprising a dwell chamber, wherein the water stream is maintained in the dwell chamber at a pasteurization temperature for a period of time effective to pasteurize the water stream;a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process; anda dialyzer system, comprising a microfluidic or flow field dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream, the dialyzer having a membrane separating the stream of dialysate from the blood stream, the membrane facilitating dialysis of the blood stream;a plurality of pumps capable of pumping the stream of dialysate across the dialyzer; anda controller operatively coupled to the plurality of pumps, the controller capable of controlling a flow rate of the dialysate stream through one or more of the plurality of pumps so as to perform one or both of the processes of ultrafiltration and hemodiafiltration on the blood stream while the blood stream is undergoing dialysis. 2. The system of claim 1, wherein the purification system produces an ultra high temperature pasteurized water stream. 3. The system of claim 1, wherein the microfluidic heat exchange system further comprises: a fluid pathway having a water inlet and a water outlet, the fluid pathway further having:(a) a first region where water flows in a first direction at a first temperature;(b) a heater region downstream of the first region, the heater region including at least one heater that transfers heat into water flowing through the heater region to increase the temperature of water flowing in the heater region to a second temperature greater than the first temperature;(c) a second region downstream of the heater region where water flows in a second direction at a temperature greater than the first temperature, wherein water flowing in the second region thermally communicates with water flowing in the first region such that heat transfers from water flowing in the second region to water flowing in the first region resulting in a temperature reduction in the water as it flows through the second region, wherein water flows out of the pathway through the outlet at a temperature less than the second temperature. 4. The system of claim 3, wherein at least a portion of the fluid pathway is at least one microchannel. 5. The system of claim 3, wherein the dwell chamber is downstream of the heater region and upstream of the second region, and wherein the water remains within the dwell chamber at or above the second temperature for at least a predetermined amount of time relative to the fluid flow rate through the dwell chamber, prior to flowing into the second region. 6. The system of claim 3, wherein the second temperature is at least 138 degrees Celsius. 7. The system of claim 3, further comprising a pump upstream of the inlet and a throttling valve downstream of the outlet, wherein the pump and throttling valve are arranged in a closed loop control arrangement for maintaining water in the fluid pathway above a saturation pressure such that the water does not change state at any point while present in the system. 8. The system of claim 3, wherein the first region, heater region, dwell chamber and second region are contained within a single laminar body. 9. The system of claim 1, wherein the dialyzer comprises a first flow field comprising a first set of support structures around which the blood stream flows during operation, a second flow field comprising a second set of support structures around which the dialysate stream flows during operation, and wherein the membrane comprises a mass transfer layer interleaved between the first and second flow fields, across which layer dialysis of the blood occurs when in operation. 10. The system of claim 1, wherein the plurality of pumps include: a first pump fluidly coupled to the stream of dialysate and configured to pump the stream of dialysate through a fluid inlet pathway toward the dialyzer;a second pump coupled to a fluid outlet pathway from the dialyzer and configured to pump the fluid through the fluid outlet pathway away from the dialyzer; anda third pump coupled to the fluid outlet pathway. 11. The system of claim 10, wherein the controller operates the first, second and third pumps to maintain balance between the fluid flow rates in the inlet pathway and outlet pathway such that substantially no fluid is added to or removed from the blood during operation. 12. The system of claim 10, wherein the controller operates the first, second and third pumps to maintain balance between the fluid flow rates in the inlet pathway and outlet pathway such that a desired amount of fluid is removed from the blood during operation. 13. The system of claim 10, wherein the controller operates the first, second and third pumps to maintain balance between the fluid flow rates in the inlet pathway and outlet pathway such that a desired amount of fluid is added to the blood during a time span of operation. 14. The system of claim 10, wherein the controller operates the first, second and third pumps to achieve a desired level of hemodiafiltration by cycling the third pump between a lower speed and a higher speed substantially without a net addition of fluid to the blood. 15. The system of claim 10, wherein the controller operates the first, second and third pumps to achieve a desired level of hemodiafiltration and a desired rate of fluid addition to the blood by cycling the third pump between a lower speed and a higher speed. 16. The system of claim 10, wherein the controller operates the first, second and third pumps to achieve a desired level of hemodiafiltration and a desired rate of fluid removal from the blood by cycling the third pump between a lower speed and a higher speed. 17. A medical system, comprising: a filtration system capable of filtering a water stream;a water purification system, capable of purifying the water stream in a non-batch process comprising a microfluidic heat exchange system having a fluid pathway comprising (a) a first region comprising a water inlet where water flows in a first direction at a first temperature;(b) a heater region downstream of the first region, comprising at least one heater to heat water flowing through the heater region to a second temperature greater than the first temperature and at least 138° C.;(c) a dwell chamber downstream of the heater region wherein the water remains within the dwell chamber at or above the second temperature for a predetermined amount of time effective to produce a concentration of less than 10−6 colony forming units per milliliter;(d) a second region downstream of the dwell chamber where water flows in a second direction at a temperature greater than the first temperature, wherein water flowing in the second region thermally communicates with water flowing in the first region such that heat transfers from water flowing in the second region to water flowing in the first region resulting in a temperature reduction in the water as it flows through the second region, so that water flowing out of the pathway through a water outlet is at a temperature less than the second temperature;a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with purified water from the water stream in a non-batch process; anda dialyzer system, comprising a microfluidic or flow field dialyzer fluidly coupled to the stream of dialysate and a blood stream, the dialyzer comprising a membrane separating the stream of dialysate from the blood stream, the membrane facilitating dialysis of the blood stream;at least one pump capable of pumping the stream of dialysate across the dialyzer; anda controller operatively coupled to at least one pump, the controller capable of controlling a flow rate of the dialysate stream through at least one pump to perform water ultrafiltration, hemodiafiltration on the blood stream while the blood stream is undergoing dialysis, or both.
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