System for targeted delivery of therapeutic agents
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-038/00
C12N-015/11
출원번호
US-0950804
(2013-07-25)
등록번호
US-8802153
(2014-08-12)
발명자
/ 주소
Cheng, Jianjun
Farokhzad, Omid C.
Langer, Robert S.
Teply, Benjamin A.
Zale, Stephen E.
출원인 / 주소
Massachusetts Institute of Technology
대리인 / 주소
Pabst Patent Group LLP
인용정보
피인용 횟수 :
3인용 특허 :
193
초록▼
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
대표청구항▼
1. A targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid, Wherein the particle is a nanoparticle having bound thereto a plurality of small molecule targeting moieties that specifically bind to the Zn2+ NAAG/PSMA binding pocket within prostate specific memb
1. A targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid, Wherein the particle is a nanoparticle having bound thereto a plurality of small molecule targeting moieties that specifically bind to the Zn2+ NAAG/PSMA binding pocket within prostate specific membrane antigen (PSMA) selected from the group consisting of 2-PMPA, GP15232, VA-033 2 MPPA, 2-MPPA, thiol and indole thiol based PSMA inhibitors, 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acid derivative PSMA inhibitors, hydroxamate derivative PSMA inhibitors, PDBA-based PSMA inhibitors, and urea-based PSMA inhibitors, andhaving encapsulated or dispersed therein a taxane. 2. The targeted particle of claim 1, wherein the taxane is docetaxel or paclitaxel. 3. The targeted particle of claim 2, wherein the taxane is docetaxel. 4. The targeted particle of claim 1, wherein the conjugated polymer comprises a copolymer of two or more polymers. 5. The targeted particle of claim 1, wherein the particle comprises a second polymer not conjugated to the surfactant, hydrophilic polymer, or lipid. 6. The targeted particle of claim 4, wherein the copolymer comprises a polymer selected from the group consisting of poly(lactide-co-glycolide) (PLGA), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), polycaprolactone, and polyanhydrides. 7. The targeted particle of claim 4, wherein the copolymer comprises a polymer selected from the group consisting of polyethylenes, polycarbonates, polyanhydrides, polyhydroxyacids, polypropylfumerates, polycaprolactones, polyamides, polyacetals, polyethers, polyesters, poly(orthoesters), polycyanoacrylates, polyvinyl alcohols, polyurethanes, polyphosphazenes, polyacrylates, polymethacrylates, polycyanoacrylates, polyureas, polystyrenes, polyamines, and combinations thereof. 8. The targeted particle of claim 4, wherein the copolymer comprises polyalkylene glycol. 9. The targeted particle of claim 8, wherein the polyalkylene glycol is polyethylene glycol (PEG). 10. The targeted particle of claim 4, wherein the copolymer is a copolymer of PLA and PEG. 11. The targeted particle of claim 1 further comprising a therapeutic, prophylactic, or diagnostic agent. 12. The targeted particle of claim 1, wherein the small molecule targeting moiety is a urea-based PSMA inhibitor. 13. A method of treating cancer in a subject, comprising administering an effective amount of a targeted particle comprising a polymer conjugated to a surfactant, hydrophilic polymer or lipid, the particle having bound thereto a plurality of small molecule targeting moieties that specifically bind to the Zn2+ NAAG/PSMA binding pocket within prostate specific membrane antigen (PSMA) selected from the group consisting of 2-PMPA, GPI5232, VA-033 2MPPA, 2-MPPA, thiol and indole thiol based PSMA inhibitors, 3-(2-mercaptoethyl)-1H-indole-2-carboxylic acid derivative PSMA inhibitors, hydroxamate derivative PSMA inhibitors, PDBA-based PSMA inhibitors, and urea-based PSMA inhibitors, andhaving encapsulated or dispersed therein a taxane. 14. The method of claim 13, wherein the taxane is docetaxel or paclitaxel. 15. The method of claim 14, wherein the taxane is docetaxel. 16. The method of claim 13, wherein the small molecule targeting moiety is a urea-based PSMA inhibitor.
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