[미국특허]
Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/085
A61K-039/40
출원번호
US-0639465
(2011-04-05)
등록번호
US-8808699
(2014-08-19)
국제출원번호
PCT/US2011/031213
(2011-04-05)
§371/§102 date
20130118
(20130118)
국제공개번호
WO2011/127032
(2011-10-13)
발명자
/ 주소
Schneewind, Olaf
Cheng, Alice
Missiakas, Dominique M.
Kim, Hwan Keun
출원인 / 주소
The University of Chicago
대리인 / 주소
Fulbright & Jaworski LLP
인용정보
피인용 횟수 :
6인용 특허 :
85
초록▼
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
대표청구항▼
1. A method for enhancing an immune response against a Staphylococcus aureus bacterium in a subject comprising: (a) providing to the subject a composition comprising an isolated antibody that specifically binds to a nontoxigenic Staphylococcus aureus Protein A (SpA) epitope SpAKKAA; and(b) providing
1. A method for enhancing an immune response against a Staphylococcus aureus bacterium in a subject comprising: (a) providing to the subject a composition comprising an isolated antibody that specifically binds to a nontoxigenic Staphylococcus aureus Protein A (SpA) epitope SpAKKAA; and(b) providing to the subject a staphylococcal antigen, wherein the antigen is selected from the group consisting of: FnBpA, FnBpB, LukD, LukE, LukF, SasA, SasD, SasG, SasI, SasK, SpA variant, Eap, Ebh, Emp, EsaB, EsaC, EsxA, EsxB, SdrC, SdrD, SdrE, IsdA, IsdB, ClfA, ClfB, Coa, Hla, IsdC, SasF, vWbp, and vWh;wherein the antibody enhances an immune response against a Staphylococcus aureus antigen. 2. The method of claim 1, wherein the antigen is present in a staphylococcal bacteria. 3. The method of claim 1, wherein the antibody is a polyclonal antibody, a monoclonal antibody, or an antibody fragment.
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McAdow, Molly; Emolo, Carla; Missiakas, Dominique; Schneewind, Olaf, Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease.
Schneewind, Olaf; Cheng, Alice; Missiakas, Dominique M.; Kim, Hwan Keun, Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response.
Schneewind, Olaf; Cheng, Alice; Missiakas, Dominique M.; Kim, Hwan Keun, Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response.
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